China Three Gorges University

About: China Three Gorges University is a education organization based out in Yichang, China. It is known for research contribution in the topics: Catalysis & Landslide. The organization has 11161 authors who have published 8011 publications receiving 82224 citations. The organization is also known as: Sanxia Daxue.

Development of Fish Passage in China

Abstract: China began to develop fish passage at hydroelectric dams in the 1960s, but few were implemented until the 2000s, when a federal law was passed in 2002 that required fish passage at new hydroelectric dams that block fish migrations. Because of this regulation, in the past 10 years, about 40 fish passage facilities have been or are being built. Even though fish scientists and hydraulic engineers are enthusiastic to develop fish passage, progress is limited mainly because of (1) the lack of an accepted and enforced process to plan, design, and evaluate fish passage; (2) the lack of knowledge on migratory fish life history movement, behavior, and swimming ability; and (3) the failure of fish biologists and engineers to work together as a fish passage team. Future development should focus on the following: educating agency staff, fish biologists, and the public on the importance of river connectivity and migratory fish conservation using fishways; improving regulations; and setting national standards that req...

UCP2 protect the heart from myocardial ischemia/reperfusion injury via induction of mitochondrial autophagy

Abstract: Uncoupling protein 2 (UCP2), located in the mitochondrial inner membrane, is a predominant isoform of UCP that expressed in the heart and other tissues of human and rodent tissues. Nevertheless, its functional role during myocardial ischemia/reperfusion (I/R) is not entirely understood. Ischemic preconditioning (IPC) remarkably improved postischemic functional recovery followed by reduced lactate dehydrogenase (LDH) release with simultaneous upregulation of UCP2 in perfused myocardium. We then investigated the role of UCP2 in IPC-afforded cardioprotective effects on myocardial I/R injury with adenovirus-mediated in vivo UCP2 overexpression (AdUCP2) and knockdown (AdshUCP2). IPC-induced protective effects were mimicked by UCP2 overexpression, while which were abolished with silencing UCP2. Mechanistically, UCP2 overexpression significantly reinforced I/R-induced mitochondrial autophagy (mitophagy), as measured by biochemical hallmarks of mitochondrial autophagy. Moreover, primary cardiomyocytes infected with AdUCP2 increased simulated ischemia/reperfusion (sI/R)-induced mitophagy and therefore reversed impaired mitochondrial function. Finally, suppression of mitophagy with mdivi-1 in cultured cardiomyocytes abolished UCP2-afforded protective effect on sI/R-induced mitochondrial dysfunction and cell death. Our data identify a critical role for UCP2 against myocardial I/R injury through preventing the mitochondrial dysfunction through reinforcing mitophagy. Our findings reveal novel mechanisms of UCP2 in the cardioprotective effects during myocardial I/R.

Mitochondrial-targeted penetrating peptide delivery for cancer therapy.

Abstract: Introduction: Mitochondria are promising targeting organelles for anticancer strategies; however, mitochondria are difficult for antineoplastic drugs to recognize and bind Mitochondria-penetrating

Temporal variation of methane flux from Xiangxi Bay of the Three Gorges Reservoir

Abstract: Three diel field campaigns and one monthly sampling campaign during June 2010-May 2011 were carried out to investigate the CH4 flux across the water-gas interface in Xiangxi Bay of the Three Gorges Reservoir, China. The average CH4 flux was much less than that reported from reservoirs in tropic and temperate regions. The photosynthesis of phytoplankton dominated the diel gas fluxes during alga bloom in spring and summer. The maximum monthly flux occurred in June 2010 and corresponded to the lowest water level. Water temperature, sediment temperature, and TOC did not have significant correlation with the monthly CH4 fluxes. Continuously decreasing hydrostatic pressure and the low water level resulted in more CH4 emission at the sediment-water during the discharging period, and thus increases the CH4 effluxes because the diffusion time through a thin water column is shorter and less CH4 may be oxidized compared with that in a long water column.