China Three Gorges University

About: China Three Gorges University is a education organization based out in Yichang, China. It is known for research contribution in the topics: Catalysis & Landslide. The organization has 11161 authors who have published 8011 publications receiving 82224 citations. The organization is also known as: Sanxia Daxue.

Slope stability analysis based on elasto-plastic finite element method

Abstract: SUMMARY The paper deals with two essential and related closely processes involved in the finite element slope stability analysis in two-dimensional problems, i.e. computation of the factors of safety (FOS) and location of the critical slide surfaces. A so-called – inequality, sin 1 − 2 is proved for any elasto-plastic material satisfying Mohr–Coulomb’s yield criterion. In order to obtain an FOS of high precision with less calculation and a proper distribution of plastic zones in the critical equilibrium state, it is stated that the Poisson’s ratio should be adjusted according to the principle that the – inequality always holds as reducing the strength parameters c and . While locating the critical slide surface represented by the critical slide line (CSL) under the plane strain condition, an initial value problem of a system of ordinary differential equations defining the CSL is formulated. A robust numerical solution for the initial value problem based on the predictor–corrector method is given in conjunction with the necessary and sufficient condition ensuring the convergence of solution. A simple example, the kinematic solution of which is available, and a challenging example from a hydraulic project in construction are analysed to demonstrate the effectiveness of the proposed procedures. Copyright 2005 John Wiley & Sons, Ltd.

Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System.

Abstract: Significance: The thioredoxin (Trx) and glutathione (GSH) systems play important roles in maintaining the redox balance in the brain, a tissue that is prone to oxidative stress due to its high-energy demand. These two disulfide reductase systems are active in various areas of the brain and are considered to be critical antioxidant systems in the central nervous system (CNS). Various neuronal disorders have been characterized to have imbalanced redox homeostasis. Recent Advances: In addition to their detrimental effects, recent studies have highlighted that reactive oxygen species/reactive nitrogen species (ROS/RNS) act as critical signaling molecules by modifying thiols in proteins. The Trx and GSH systems, which reversibly regulate thiol modifications, regulate redox signaling involved in various biological events in the CNS. Critical Issues: In this review, we focus on the following: (i) how ROS/RNS are produced and mediate signaling in CNS; (ii) how Trx and GSH systems regulate redox signaling...