Institution
China Three Gorges University
Education•Yichang, China•
About: China Three Gorges University is a education organization based out in Yichang, China. It is known for research contribution in the topics: Catalysis & Landslide. The organization has 11161 authors who have published 8011 publications receiving 82224 citations. The organization is also known as: Sanxia Daxue.
Papers published on a yearly basis
Papers
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TL;DR: In this article, a diffusive SIRS epidemic system in spatially heterogeneous and time periodic environment with no flux boundary condition was considered and the authors established the uniform persistence if the basic reproduction number R 0 > 1.
33 citations
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TL;DR: Data indicate that down-regulation of CD47 exerts a protective effect against MIRI, which may be attributable to attenuation of oxidative stress via activation of the eNOS/NO signaling pathway.
Abstract: Background/Aims: Oxidative stress is strongly implicated in the pathogenesis of myocardial damage caused by ischemia reperfusion (I/R). Previous studies have confirmed that cardiac CD47 drives left ventricular heart failure. However, the role for CD47 in myocardial I/R injury (MIRI) has not previously been proposed. This study was designed to investigate whether down-regulation of CD47 using RNA interference (RNAi) technology can relieve inhibition of nitric oxide signaling and attenuate myocardial damage in a rat model of I/R. Methods: Male Sprague-Dawley rats (n = 40) were randomly allocated to four groups and pre-treated either with saline (Sham and I/R groups), or adenovirus expressing either control (Ad-EGFP-N) or CD47-targeting (Ad-EGFP-CD47) RNAi. After four days, the rat MIRI model was established by occluding the left anterior descending coronary artery for 30 min, followed by reperfusion for 3 h. Heart tissue was harvested and assessed by immunohistochemistry, western blot, and quantitative RT-PCR. Outcome measures included infarct size, myocardial enzyme (creatine kinase, creatine kinase-MB, and lactate dehydrogenase) levels in serum, markers of oxidative stress, and morphological changes to the myocardium. Results: Delivery of Ad-EGFP-CD47 RNAi into the myocardium remarkably decreased CD47 expression levels. Down-regulation of CD47 was significantly associated with reduced infarct size and serum levels of myocardial enzymes, increased activity of endothelial nitric oxide synthase, increased levels of nitric oxide, and decreased levels of oxidative stress. Conclusion: These data indicate that down-regulation of CD47 exerts a protective effect against MIRI, which may be attributable to attenuation of oxidative stress via activation of the eNOS/NO signaling pathway.
33 citations
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TL;DR: In this paper, a new blasting approach of combined blastholes with different diameters is proposed to solve the problems of oversize boulders and rock toes in open-pit mine.
Abstract: A new blasting approach of combined blastholes with different diameters is proposed to solve the problems of oversize boulders and rock toes in open-pit mine. A non-ideal detonation model and a statistical damage constitutive model are implemented in dynamic finite element analysis to investigate the formation mechanism of oversize boulders and toes. The damage distribution and evolution process of rock blasting fragmentation is simulated, and the scheme is further optimized. Numerical analysis results showed that pocket charges and satellite blastholes can only improve bench top fragmentation, but they cannot reduce the oversize in the middle and bottom of bench as well as the toe problem. The new blasting approach of combined blastholes with different diameters can effectively reduce the oversize boulders and toes as well as the production costs.
33 citations
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TL;DR: The results suggest that miR-22 plays an important cardioprotective role partly via regulating CBP/AP-1 pathway to reduce cell apoptosis and inflammatory damage during MI/R injury.
33 citations
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TL;DR: In this article, a scaled boundary finite element (SDFE) method is employed for modeling the near-field bounded domains of a soil-structure interaction system and a procedure for coupling the bounded domains with an improved continued-fraction-based high-order transmitting boundary is established.
Abstract: Dynamic fracture analysis of the soil-structure interaction system by using the scaled boundary finite element method is presented in this paper. The polygon scaled boundary finite elements, which have some salient features to model any star convex polygons, are employed for modelling the near-field bounded domains. A procedure for coupling the bounded domains with an improved continued-fraction-based high-order transmitting boundary is established. The formulations of the soil-structure interaction system are coupled via the interaction force vector at the interface. The dynamic stress intensity factors and T-stress are extracted according to the definition of the generalized stress intensity factors. The dynamic stress intensity factors of the coupled system are evaluated accurately and efficiently. Two numerical examples are demonstrated to validate the developed method.
33 citations
Authors
Showing all 11222 results
Name | H-index | Papers | Citations |
---|---|---|---|
Shu Li | 136 | 1001 | 78390 |
Yu Huang | 136 | 1492 | 89209 |
Jian Zhang | 107 | 3064 | 69715 |
Tao Li | 102 | 2483 | 60947 |
Jian Chen | 96 | 1718 | 52917 |
Jing Zhang | 95 | 1271 | 42163 |
Qichun Zhang | 94 | 540 | 28367 |
Bin Li | 92 | 1755 | 42835 |
Xianhui Bu | 87 | 290 | 20927 |
Dawei Wang | 85 | 934 | 41226 |
Guangshan Zhu | 77 | 369 | 21281 |
Fei Xu | 71 | 743 | 24009 |
Jian Zhang | 70 | 317 | 14802 |
Ying Wu | 70 | 489 | 22952 |
Chao Zhang | 69 | 331 | 23555 |