China Three Gorges University

About: China Three Gorges University is a education organization based out in Yichang, China. It is known for research contribution in the topics: Catalysis & Landslide. The organization has 11161 authors who have published 8011 publications receiving 82224 citations. The organization is also known as: Sanxia Daxue.

Automatic Generation Control Based on Multiple Neural Networks With Actor-Critic Strategy

Abstract: As the conventional automatic generation control (AGC) is inadequate to deal with the strong random disturbance issues induced by the ever-increasing penetration of renewable energy to the power grids, this article proposes a deep-reinforcement-learning-based three-network double-delay actor-critic (TDAC) control strategy for AGC to handle the above problem, which is mainly developed by multiple neural networks to fit the system action strategies and evaluate the value. The proposed strategy can increase the exploration efficiency and the quality of AGC and improve the system control performance using the modified actor-critic (AC) method with incentive heuristic mechanism, while a novel iterative way of the value function is also used to reduce the bias of optimization effectively for achieving optimal coordinated control of the power grid. The simulations are provided in the work to show the control performance of the strategy. Compared with other smart methods, the simulation study demonstrates that TDAC has excellent exploratory stability and learning ability. Meanwhile, it also can improve the dynamic performance of the power system and achieve the regional optimal coordinated control.

H19 promotes non-small-cell lung cancer (NSCLC) development through STAT3 signaling via sponging miR-17.

Abstract: LncRNAs can exhibit crucial roles in the development of multiple cancers, including non-small cell lung cancer (NSCLC). Currently, we investigated the role of lncRNA H19 in NSCLC. In our study, it was found that H19 was upregulated in A549 and H1299 cells compared to normal lung epithelial BEAS-2B cells. Meanwhile, we observed that miR-17 was downregulated in NSCLC cell lines. Inhibited H19 can suppress the growth, migration, and invasion of NSCLC cells and bioinformatics search was performed to predict the correlation between H19 and miR-17. Overexpression of miR-17 was able to inhibit the progression of NSCLC cells while reversely miR-17 inhibitors reversed this process. In addition, signal transducers and activators of transcription (STAT3), as an mRNA target of miR-17, was presented in our research. Moreover, we discovered that H19 demonstrated its biological functions via regulating miR-17 and STAT3 in vitro. Silencing H19 greatly increased STAT3 expression by sponging miR-19 in vitro. It was hypothesized that H19 may serve as a competing endogenous RNA (ceRNA) to modulate STAT3 by attaching miR-17 in lung cancer. In summary, our findings indicated that H19/miR-17/STAT3 axis participated in NSCLC development. H19 could be regarded as a significant prognostic biomarker in NSCLC progression.