China Three Gorges University

About: China Three Gorges University is a education organization based out in Yichang, China. It is known for research contribution in the topics: Catalysis & Landslide. The organization has 11161 authors who have published 8011 publications receiving 82224 citations. The organization is also known as: Sanxia Daxue.

A series of divalent metal coordination polymers based on isomeric tetracarboxylic acids: synthesis, structures and magnetic properties

Abstract: Five new coordination polymers, namely, [Mn(2,2′-bipy)(H2O)2(H2L1)]n (1), {[Co(btb)(H2O)2(H2L1)]·0.5H2O}n (2), [Co(bib)(H2O)2(H2L1)]n (3), [Ni2(bpm)(H2O)3(L2)]n (4), and {[Co2(H2O)3(OH)(HL2)]·H2O}n (5), (H4L1 = 1,1′:2′,1′′-terphenyl-4,4′,4′′,5′-tetracarboxylic acid, H4L2 = 1,1′:2′,1′′-terphenyl-3,3′′,4′,5′-tetracarboxylic acid, 2,2′-bipy = 2,2′-bipyridine, btb = 1,4-bis(1,2,4-triazol-1-yl)butane, bib = 1,4-bis(imidazol-1-yl)butane, bpm = bis(4-pyridyl)amine), have been obtained under hydrothermal conditions. Complex 1 exhibits a 3D supramolecular framework based on 1D chains. Both complexes 2 and 3 are 3D supramolecular frameworks constructed from 1D zig-zag chains. Complex 4 features a 3D tetra-nodal (3,4,4,5)-connected architecture containing 1D μ-COO bridged chains with (52·62·7.9)(52·64·73·8)2(52·6)2(63·72·9) topology. Complex 5 shows a 3D penta-nodal (3,4,4,6,6)-connected net containing 1D μ-OH/μ-COO bridged chains and mononuclear Co(II) nodes with a (42·63·8)(43)2(44·62)2(44·66·85)2(44·67·84) topology. Variable-temperature magnetic susceptibility measurements reveal that complexes 2 and 3 show antiferromagnetic interactions between the adjacent Co(II) ions, whereas 4 is a ferromagnetic system.

Event-triggered guaranteed cost control for uncertain discrete-time networked control systems with time-varying transmission delays

Abstract: In this study, event-triggered guaranteed cost control problem for discrete-time networked control systems (NCSs) with parameter uncertainties and time-varying transmission delays is studied. First, an event-triggering scheme for discrete-time NCSs is proposed. Then by using a delay system approach, a unified model of event-triggered control systems with parameter uncertainties and state delay is established. By applying Laypunov functional method together with linear matrix inequality (LMI) technique, sufficient conditions for the existence of an admissible guaranteed cost controller are established, which ensure a specific quadratic cost function has an upper bound for all admissible uncertainties. The proposed stability and stabilisation conditions are formulated in the framework of LMIs, which can be solved efficiently by using existing optimisation techniques. Finally, a numerical example and a practical example are given to demonstrate that, under the proposed event-triggering scheme, the advantage of reducing communication traffic in a control network without compromising the stability of the closed-loop system is preserved.

MiRNA-543 promotes osteosarcoma cell proliferation and glycolysis by partially suppressing PRMT9 and stabilizing HIF-1α protein.

Abstract: // Heng Zhang 1, * , Xiaofeng Guo 7, * , Xing Feng 2 , Tingting Wang 3, 4, * , Zhaohua Hu 1 , Xiangyong Que 1 , Qingsong Tian 5 , Tianbo Zhu 5 , Guixian Guo 6 , Wei Huang 1 , Xinzhi Li 1 1 Department of Orthopedics, Renhe Hospital, China Three Gorges University, Yichang, Hubei, China 2 Department of Molecular Pharmacology, Rutgers University, New Brunswick, New Jersey, USA 3 Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China 4 National Clinical Research Center of Digestive Diseases, Beijing, China 5 Department of Medicine, Medical College, China Three Gorges University, Yichang, Hubei, China 6 Department of Medicine, The Second Hospital Affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China 7 Medical College of Xiamen University, Xiamen, Fujian, China * These authors contributed equally to this work Correspondence to: Xinzhi Li, email: xinzhilirenhe@163.com Xing Feng, email: fengx1@cinj.rutgers.edu Keywords: osteosarcoma, miRNA-543, glycolysis, PRMT9, HIF-1α Received: April 17, 2016 Accepted: November 06, 2016 Published: November 28, 2016 ABSTRACT Osteosarcoma (OS) is the most common primary bone tumor, occurring frequently in adolescents and possessing a high malignant severity. MicroRNAs play critical roles during OS development. Thus, elucidation of the involvement of specific microRNAs in the development of OS may provide novel therapeutic targets for OS treatment. Here, we showed that in the OS specimens from patients, the levels of miR-543 were significantly increased whereas the levels of PRMT9 were significantly decreased, compared to the paired normal bone tissue. Moreover, miR-543 and PRMT9 inversely correlated in the OS cell lines. Bioinformatics analyses predicted that miR-543 may target the 3'-UTR of PRMT9 mRNA to inhibit its translation, which was confirmed by luciferase-reporter assay. MiR-543 promoted OS cell proliferation in vitro and in vivo . Mechanistically, miR-543 inhibited PRMT9-enhanced cell oxidative phosphorylation, while miR-543 depletion promoted PRMT9-increased HIF-1α instability and inhibited glycolysis in OS cells. Clinically, miR-543 expression was negatively correlated with PRMT9 expression in OS tissues. Together, our data provide important evidence for glycolysis in OS development, and suggest that targeting glycolytic pathway through miR-543/PRMT9/HIF-1α axis may represent a potential therapeutic strategy to eradicate OS cells.