Institution
Fraunhofer Society
Government•Munich, Germany•
About: Fraunhofer Society is a government organization based out in Munich, Germany. It is known for research contribution in the topics: Laser & Silicon. The organization has 24736 authors who have published 40168 publications receiving 820894 citations.
Topics: Laser, Silicon, Thin film, Solar cell, CAS Registry Number
Papers published on a yearly basis
Papers
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TL;DR: The multiplexed FRET biosensor offers clinically relevant detection limits in the low picomolar concentration range for all five markers, thus providing an effective early screening tool for lung cancer with the possibility of distinguishing small-cell from non-small-cell lung carcinoma.
Abstract: Simultaneous monitoring of multiple molecular interactions and multiplexed detection of several diagnostic biomarkers at very low concentrations have become important issues in advanced biological and chemical sensing. Here we present an optically multiplexed six-color Forster resonance energy transfer (FRET) biosensor for simultaneous monitoring of five different individual binding events. We combined simultaneous FRET from one Tb complex to five different organic dyes measured in a filter-based time-resolved detection format with a sophisticated spectral crosstalk correction, which results in very efficient background suppression. The advantages and robustness of the multiplexed FRET sensor were exemplified by analyzing a 15-component lung cancer immunoassay involving 10 different antibodies and five different tumor markers in a single 50 μL human serum sample. The multiplexed biosensor offers clinically relevant detection limits in the low picomolar (ng/mL) concentration range for all five markers, thus providing an effective early screening tool for lung cancer with the possibility of distinguishing small-cell from non-small-cell lung carcinoma. This novel technology will open new doors for multiple biomarker diagnostics as well as multiplexed real-time imaging and spectroscopy.
171 citations
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23 Dec 2015
TL;DR: Some devices showed steady aging but many failed catastrophically due to corrosion of electrodes not active device layers, and degradation of cells kept in dark storage was minimal over periods up to one year.
Abstract: We report on the degradation of organic photovoltaic (OPV) cells in both indoor and outdoor environments. Eight different research groups contributed state of the art OPV cells to be studied at Pomona College. Power conversion efficiency, fill factor, and IV curves were collected at regular intervals over six to eight months. Similarly prepared devices were measured indoors, outdoors, and after dark storage. Device architectures are compared. Cells kept indoors performed better than outdoors due to the lack of temperature and humidity extremes. Encapsulated cells performed better due to the minimal oxidation. Some devices showed steady aging but many failed catastrophically due to corrosion of electrodes not active device layers. Degradation of cells kept in dark storage was minimal over periods up to one year.
171 citations
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TL;DR: The first clinical use of multiphoton endoscopes is reported on, in particular of a miniaturized rigid two‐photon GRIN lens endoscope attached to the multipoton tomograph DermaInspect and employed to detect the extracellular matrix proteins collagen and elastin in the human dermis of volunteers and patients with ulcera.
Abstract: Two-photon medical imaging has found its way into dermatology as an excellent method for noninvasive skin cancer detection without need of contrast agents as well as for in situ drug screening of topically-applied cosmetical and pharmaceutical components. There is an increasing demand to apply the multiphoton technology also for deep-tissue skin imaging as well as for intracorporal imaging. We report on the first clinical use of multiphoton endoscopes, in particular of a miniaturized rigid two-photon GRIN lens endoscope. The microendoscope was attached to the multiphoton tomograph DermaInspect and employed to detect the extracellular matrix proteins collagen and elastin in the human dermis of volunteers and patients with ulcera by in vivo second harmonic generation and in vivo two-photon autofluorescence.
171 citations
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TL;DR: A range of transgenic approaches that could increase agricultural productivity if applied on a large scale are discussed, including the introduction of genes that confer resistance to pests and diseases, or tolerance of harsh environments, and genes that help to lift the intrinsic yield capacity by increasing metabolic flux towards storage carbohydrates, proteins and oils.
Abstract: Food insecurity is one of the most important social issues faced today, with 840 million individuals enduring chronic hunger and three billion individuals suffering from nutrient deficiencies. Most of these individuals are poverty stricken and live in developing countries. Strategies to address food insecurity must aim to increase agricultural productivity in the developing world in order to tackle poverty, and must provide long-term improvements in crop yields to keep up with demand as the world's population grows. Genetically enhanced plants provide one route to sustainable higher yields, either by increasing the intrinsic yield capability of crop plants or by protecting them from biotic and abiotic constraints. The present paper discusses a range of transgenic approaches that could increase agricultural productivity if applied on a large scale, including the introduction of genes that confer resistance to pests and diseases, or tolerance of harsh environments, and genes that help to lift the intrinsic yield capacity by increasing metabolic flux towards storage carbohydrates, proteins and oils. The paper also explores how the nutritional value of plants can be improved by genetic engineering. Transgenic plants, as a component of integrated strategies to relieve poverty and deliver sustainable agriculture to subsistence farmers in developing countries, could have a significant impact on food security now and in the future.
171 citations
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TL;DR: This study describes host cell signaling events upon Sars-CoV-2 infection and reveals GFR signaling as central pathway essential for SARS-Cov-2 replication, providing with novel strategies for COVID-19 treatment.
171 citations
Authors
Showing all 24741 results
Name | H-index | Papers | Citations |
---|---|---|---|
Christian Gieger | 157 | 617 | 113657 |
J. Fraser Stoddart | 147 | 1239 | 96083 |
Klaus-Robert Müller | 129 | 764 | 79391 |
Ron Kikinis | 126 | 684 | 63398 |
Thomas Schwarz | 123 | 701 | 54560 |
Alexander J. Smola | 122 | 434 | 110222 |
Yang Li | 117 | 1319 | 63111 |
Paul Turner | 114 | 1099 | 61390 |
Wil M. P. van der Aalst | 108 | 725 | 42429 |
Ivan Dikic | 107 | 359 | 52088 |
Peter F. Stadler | 103 | 901 | 56813 |
Ralph Müller | 102 | 677 | 40888 |
Stefan Kaskel | 101 | 705 | 36201 |
Andreas Tünnermann | 97 | 1738 | 43757 |
Wenjun Zhang | 96 | 976 | 38530 |