Institution
Helsinki University of Technology
About: Helsinki University of Technology is a based out in . It is known for research contribution in the topics: Artificial neural network & Finite element method. The organization has 8962 authors who have published 20136 publications receiving 723787 citations. The organization is also known as: TKK & Teknillinen korkeakoulu.
Papers published on a yearly basis
Papers
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TL;DR: The time course and cortical basis of reading comprehension were studied using magnetoencephalography and it is proposed that the point in time where the response to appropriate but unexpected endings started to diverge from those to contextually inappropriate endings reflects the boundary between understanding a single word and the meaning of a whole sentence.
Abstract: The time course and cortical basis of reading comprehension were studied using magnetoencephalography. The cortical structures implicated most consistently with comprehension were located in the immediate vicinity of the left auditory cortex, where final words totally inappropriate to the overall sentence context evoked enduring activation starting approximately 250 ms and lasting up to 600 ms after word onset. Contextually appropriate but unexpected words produced weaker activation which terminated earlier. Highly anticipated words totally failed to activate this area, suggesting that the conceptual network became involved only if unexpected information was detected during the primary word identification process. We propose that the point in time (350 ms after word onset) where the response to appropriate but unexpected endings started to diverge from those to contextually inappropriate endings reflects the boundary between understanding a single word and the meaning of a whole sentence.
270 citations
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TL;DR: Significant differentially expressed miRNAs were identified in smokers versus nonsmokers, but not in asbestos‐exposed patients versus nonexposed ones, and risk factors such as smoking status and asbestos exposure were identified.
Abstract: Malignant mesothelioma (MM) is an aggressive cancer arising from mesothelial cells, mainly due to former asbestos exposure. Little is known about the microRNA (miRNA) expression of MM. miRNAs are small noncoding RNAs, which play an essential role in the regulation of gene expression. This study was carried out to analyze the miRNA expression profile of 17 MM samples using miRNA microarray. The analysis distinguished the overall miRNA expression profiles of tumor tissue and normal mesothelium. Differentially expressed miRNAs were found in tumor samples compared with normal sample. Twelve of them, let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p, were highly expressed whereas the remaining nine, let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR423, miR-582, miR-7-1*, and miR-9, were unexpressed or had severely reduced expression levels. Target genes for these miRNAs include the most frequently affected genes in MM such as CDKN2A, NF2, JUN, HGF, and PDGFA. Many of the miRNAs were located in chromosomal areas known to be deleted or gained in MM such as 8q24, 1p36, and 14q32. Furthermore, we could identify specific miRNAs for each histopathological subtype of MM. Regarding risk factors such as smoking status and asbestos exposure, significantly differentially expressed miRNAs were identified in smokers versus nonsmokers (miR-379, miR-301a, miR-299-3p, miR-455-3p, and miR-127-3p), but not in asbestos-exposed patients versus nonexposed ones. This could be related to the method of assessment of asbestos exposure as asbestos remains to be the main contributor to the development of MM. V C 2009 Wiley-Liss, Inc.
270 citations
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University of Antwerp1, Centre national de la recherche scientifique2, Max Planck Society3, Wageningen University and Research Centre4, University of Bordeaux5, University of Edinburgh6, University of Bologna7, European Forest Institute8, Helsinki University of Technology9, VU University Amsterdam10
TL;DR: In this article, the authors present a new synthesis, based on a suite of complementary approaches, of the primary production and carbon sink in forests of the 25 member states of the European Union (EU-25) during 1990-2005.
Abstract: We present a new synthesis, based on a suite of complementary approaches, of the primary production and carbon sink in forests of the 25 member states of the European Union (EU-25) during 1990-2005. Upscaled terrestrial observations and model-based approaches agree within 25% on the mean net primary production (NPP) of forests, i.e. 520 +/- 75 g C m-2 yr-1 over a forest area of 1.32 x 106 km2 to 1.55 x 106 km2 (EU-25). New estimates of the mean long-term carbon forest sink (net biome production, NBP) of EU-25 forests amounts 75 +/- 20 g C m-2 yr-1. The ratio of NBP to NPP is 0.15 +/- 0.05. Estimates of the fate of the carbon inputs via NPP in wood harvests, forest fires, losses to lakes and rivers and heterotrophic respiration remain uncertain, which explains the considerable uncertainty of NBP. Inventory-based assessments and assumptions suggest that 29 +/- 15% of the NBP (i.e., 22 g C m-2 yr-1) is sequestered in the forest soil, but large uncertainty remains concerning the drivers and future of the soil organic carbon. The remaining 71 +/- 15% of the NBP (i.e., 53 g C m-2 yr-1) is realized as woody biomass increments. In the EU-25, the relatively large forest NBP is thought to be the result of a sustained difference between NPP, which increased during the past decades, and carbon losses primarily by harvest and heterotrophic respiration, which increased less over the same period.
269 citations
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06 Jan 2007TL;DR: Within the general framework of backtracking algorithms based on individualization and refinement, data structures, subroutines, and pruning heuristics especially for fast handling of large and sparse graphs are developed.
Abstract: The problem of canonically labeling a graph is studied. Within the general framework of backtracking algorithms based on individualization and refinement, data structures, subroutines, and pruning heuristics especially for fast handling of large and sparse graphs are developed. Experiments indicate that the algorithm implementation in most cases clearly outperforms existing state-of-the-art tools.
269 citations
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TL;DR: In this paper, the use of airborne and simulated satellite remote sensing data for classification of three water quality variables: Secchi depth, turbidity, and chlorophyll a was studied.
269 citations
Authors
Showing all 8962 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ashok Kumar | 151 | 5654 | 164086 |
Hannu Kurki-Suonio | 138 | 433 | 99607 |
Nicolas Gisin | 125 | 827 | 64298 |
Anne Lähteenmäki | 116 | 485 | 81977 |
Riitta Hari | 111 | 491 | 43873 |
Andreas Richter | 110 | 769 | 48262 |
Mika Sillanpää | 96 | 1019 | 44260 |
Markku Leskelä | 94 | 876 | 36881 |
Ullrich Scherf | 92 | 735 | 36972 |
Mikko Ritala | 91 | 584 | 29934 |
Axel H. E. Müller | 89 | 564 | 30283 |
Karl Henrik Johansson | 88 | 1089 | 33751 |
T. Poutanen | 86 | 120 | 33158 |
Elina Lindfors | 86 | 420 | 23846 |
Günter Breithardt | 85 | 554 | 33165 |