Institution
Ikerbasque
Other•Bilbao, Spain•
About: Ikerbasque is a other organization based out in Bilbao, Spain. It is known for research contribution in the topics: Graphene & Quantum. The organization has 713 authors who have published 7967 publications receiving 231990 citations. The organization is also known as: Basque Foundation for Science.
Topics: Graphene, Quantum, Population, Galaxy, Magnetization
Papers published on a yearly basis
Papers
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TL;DR: A SERS-based method for the simultaneous and independent determination of two environmental metallic pollutants, Cu(ii) and Co(ii), achieved by exploiting the coordination-sensitive Raman bands of a terpyridine (TPY) derivative for detecting transition metal ions is reported.
Abstract: We report a SERS-based method for the simultaneous and independent determination of two environmental metallic pollutants, Cu(II) and Co(II). This was achieved by exploiting the coordination-sensitive Raman bands of a terpyridine (TPY) derivative for detecting transition metal ions. Changes in the vibrational SERS spectra of dithiocarbamate anchored terpyridine (TPY-DTC) were correlated as a function of each metal ion concentration, with limits of detection comparable to those of several conventional analytical methods. Simultaneous detection of ultratrace levels of Co(II) in the presence of high Cu(II) concentration was also demonstrated, supporting the potential of this sensing strategy for monitoring potable water supplies.
86 citations
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TL;DR: Bv109ICWD showed unique characteristics of “virulence”, low PrPres accumulation and high infectivity, thus providing exceptional opportunities to improve basic knowledge of the relationship between PrPSc, neurodegeneration and infectivity.
Abstract: In order to assess the susceptibility of bank voles to chronic wasting disease (CWD), we inoculated voles carrying isoleucine or methionine at codon 109 (Bv109I and Bv109M, respectively) with CWD isolates from elk, mule deer and white-tailed deer. Efficient transmission rate (100%) was observed with mean survival times ranging from 156 to 281 days post inoculation. Subsequent passages in Bv109I allowed us to isolate from all CWD sources the same vole-adapted CWD strain (Bv109ICWD), typified by unprecedented short incubation times of 25–28 days and survival times of ∼35 days. Neuropathological and molecular characterisation of Bv109ICWD showed that the classical features of mammalian prion diseases were all recapitulated in less than one month after intracerebral inoculation. Bv109ICWD was characterised by a mild and discrete distribution of spongiosis and relatively low levels of protease-resistant PrPSc (PrPres) in the same brain regions. Despite the low PrPres levels and the short time lapse available for its accumulation, end-point titration revealed that brains from terminally-ill voles contained up to 108,4 i.c. ID50 infectious units per gram. Bv109ICWD was efficiently replicated by protein misfolding cyclic amplification (PMCA) and the infectivity faithfully generated in vitro, as demonstrated by the preservation of the peculiar Bv109ICWD strain features on re-isolation in Bv109I. Overall, we provide evidence that the same CWD strain was isolated in Bv109I from the three-cervid species. Bv109ICWD showed unique characteristics of “virulence”, low PrPres accumulation and high infectivity, thus providing exceptional opportunities to improve basic knowledge of the relationship between PrPSc, neurodegeneration and infectivity.
86 citations
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TL;DR: It is shown that BMP and WNT signaling drive cardiac specification by removing sequential roadblocks that otherwise redirect hESC differentiation toward competing fates, rather than activating a cardiac program per se.
86 citations
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30 Jan 2019TL;DR: Ceramic polymer solid electrolytes, combined with Li metal anodes, hold the promise for safer and more energetically dense battery technologies, as long as key interfacial challenges are fully unde...
Abstract: Ceramic–polymer solid electrolytes, combined with Li metal anodes, hold the promise for safer and more energetically dense battery technologies, as long as key interfacial challenges are fully unde...
86 citations
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TL;DR: The use of tailored HEs opens up new possibilities for gene therapy in patients with monogenic diseases that can be treated ex vivo, and several members of this enzyme family have been used as templates to engineer tools to cleave DNA sequences that differ from their original wild-type targets.
Abstract: Homing endonucleases (HE) are double-stranded DNAses that target large recognition sites (12-40 bp). HE-encoding sequences are usually embedded in either introns or inteins. Their recognition sites are extremely rare, with none or only a few of these sites present in a mammalian-sized genome. However, these enzymes, unlike standard restriction endonucleases, tolerate some sequence degeneracy within their recognition sequence. Several members of this enzyme family have been used as templates to engineer tools to cleave DNA sequences that differ from their original wild-type targets. These custom HEs can be used to stimulate double-strand break homologous recombination in cells, to induce the repair of defective genes with very low toxicity levels. The use of tailored HEs opens up new possibilities for gene therapy in patients with monogenic diseases that can be treated ex vivo. This review provides an overview of recent advances in this field.
86 citations
Authors
Showing all 775 results
Name | H-index | Papers | Citations |
---|---|---|---|
Luis M. Liz-Marzán | 132 | 616 | 61684 |
Maurizio Prato | 109 | 741 | 63055 |
Francisco Guinea | 108 | 573 | 69426 |
Rafael Yuste | 104 | 342 | 37415 |
Tom Broadhurst | 96 | 422 | 30074 |
Alexei Verkhratsky | 89 | 450 | 29788 |
Maria Forsyth | 84 | 749 | 33340 |
J. Garay Garcia | 81 | 348 | 23275 |
Ángel Borja | 77 | 316 | 20302 |
Wei Zhang | 76 | 1932 | 34966 |
Mirko Prato | 76 | 370 | 21189 |
Nate Bastian | 76 | 355 | 18342 |
A. J. Castro-Tirado | 72 | 728 | 24272 |
Rainer Hillenbrand | 71 | 227 | 18259 |
B. Andrei Bernevig | 69 | 280 | 29935 |