Institution
Ikerbasque
Other•Bilbao, Spain•
About: Ikerbasque is a other organization based out in Bilbao, Spain. It is known for research contribution in the topics: Graphene & Quantum. The organization has 713 authors who have published 7967 publications receiving 231990 citations. The organization is also known as: Basque Foundation for Science.
Topics: Graphene, Quantum, Population, Galaxy, Magnetization
Papers published on a yearly basis
Papers
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TL;DR: It is argued that glial–neuronal interactions provide a core hub integrating food-related cues, interoceptive signals, and internal states to adapt a complex set of physiological responses operating on different timescales to finely tune behavior and metabolism according to metabolic status.
Abstract: Astrocytes, microglia, and tanycytes play active roles in the regulation of hypothalamic feeding circuits. These non-neuronal cells are crucial in determining the functional interactions of specific neuronal subpopulations involved in the control of metabolism. Recent advances in biology, optics, genetics, and pharmacology have resulted in the emergence of novel and highly sophisticated approaches for studying hypothalamic neuronal-glial networks. Here we summarize the progress in the field and argue that glial-neuronal interactions provide a core hub integrating food-related cues, interoceptive signals, and internal states to adapt a complex set of physiological responses operating on different timescales to finely tune behavior and metabolism according to metabolic status. This expanding knowledge helps to redefine our understanding of the physiology of food intake and energy metabolism.
175 citations
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TL;DR: Sub-nanometre spatial control over the coherent coupling between a single molecule and a plasmonic nanocavity in close proximity is demonstrated by monitoring the evolution of Fano lineshapes and photonic Lamb shifts in tunnelling electron-induced luminescence spectra.
Abstract: The coherent interaction between quantum emitters and photonic modes in cavities underlies many of the current strategies aiming at generating and controlling photonic quantum states. A plasmonic nanocavity provides a powerful solution for reducing the effective mode volumes down to nanometre scale, but spatial control at the atomic scale of the coupling with a single molecular emitter is challenging. Here we demonstrate sub-nanometre spatial control over the coherent coupling between a single molecule and a plasmonic nanocavity in close proximity by monitoring the evolution of Fano lineshapes and photonic Lamb shifts in tunnelling electron-induced luminescence spectra. The evolution of the Fano dips allows the determination of the effective interaction distance of ∼1 nm, coupling strengths reaching ∼15 meV and a giant self-interaction induced photonic Lamb shift of up to ∼3 meV. These results open new pathways to control quantum interference and field–matter interaction at the nanoscale. Assessing the coupling between a plasmonic nanocavity and a single quantum emitter is challenging due to the lack of spatial control at the atomic scale. Here Zhanget al. achieve control with sub-nanometre precision and demonstrate the Fano resonance and Lamb shift at the single-molecule level.
174 citations
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Duke University1, Champalimaud Foundation2, Icahn School of Medicine at Mount Sinai3, University of Ferrara4, Randall Division of Cell and Molecular Biophysics5, Complutense University of Madrid6, Memorial Sloan Kettering Cancer Center7, Catalan Institution for Research and Advanced Studies8, Ikerbasque9, University of the Basque Country10
TL;DR: A signature based on the PGC1α–ERRα pathway exhibited prognostic potential in prostate cancer, thus uncovering the relevance of monitoring and manipulating this pathway for prostate cancer stratification and treatment.
Abstract: Cellular transformation and cancer progression is accompanied by changes in the metabolic landscape. Master co-regulators of metabolism orchestrate the modulation of multiple metabolic pathways through transcriptional programs, and hence constitute a probabilistically parsimonious mechanism for general metabolic rewiring. Here we show that the transcriptional co-activator peroxisome proliferator-activated receptor gamma co-activator 1α (PGC1α) suppresses prostate cancer progression and metastasis. A metabolic co-regulator data mining analysis unveiled that PGC1α is downregulated in prostate cancer and associated with disease progression. Using genetically engineered mouse models and xenografts, we demonstrated that PGC1α opposes prostate cancer progression and metastasis. Mechanistically, the use of integrative metabolomics and transcriptomics revealed that PGC1α activates an oestrogen-related receptor alpha (ERRα)-dependent transcriptional program to elicit a catabolic state and metastasis suppression. Importantly, a signature based on the PGC1α-ERRα pathway exhibited prognostic potential in prostate cancer, thus uncovering the relevance of monitoring and manipulating this pathway for prostate cancer stratification and treatment.
174 citations
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TL;DR: This review provides an insight into the synthesis and applications of innovative poly(ethylenedioxythiophene)-type materials for bioelectronics such as biocompatible conducting polymer layers, conducting hydrogels, biosensors, selective detachment of cells, scaffolds for tissue engineering, electrodes for electrophysiology, implantable electrodes, stimulation of neuronal cells or pan-bio electronics.
Abstract: Poly(3,4-ethylenedioxythiophene)s are the conducting polymers (CP) with the biggest prospects in the field of bioelectronics due to their combination of characteristics (conductivity, stability, transparency and biocompatibility). The gold standard material is the commercially available poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS). However, in order to well connect the two fields of biology and electronics, PEDOT:PSS presents some limitations associated with its low (bio)functionality. In this review, we provide an insight into the synthesis and applications of innovative poly(ethylenedioxythiophene)-type materials for bioelectronics. First, we present a detailed analysis of the different synthetic routes to (bio)functional dioxythiophene monomer/polymer derivatives. Second, we focus on the preparation of PEDOT dispersions using different biopolymers and biomolecules as dopants and stabilizers. To finish, we review the applications of innovative PEDOT-type materials such as biocompatible conducting polymer layers, conducting hydrogels, biosensors, selective detachment of cells, scaffolds for tissue engineering, electrodes for electrophysiology, implantable electrodes, stimulation of neuronal cells or pan-bio electronics.
173 citations
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University of Michigan1, University of Giessen2, Petersburg Nuclear Physics Institute3, VU University Amsterdam4, University of Glasgow5, University of Ferrara6, Istituto Superiore di Sanità7, Ghent University8, University of Erlangen-Nuremberg9, University of Illinois at Urbana–Champaign10, University of Colorado Boulder11, TRIUMF12, Ikerbasque13, Tokyo Institute of Technology14, Argonne National Laboratory15, Joint Institute for Nuclear Research16, Peking University17, University of Regensburg18, University of the Basque Country19
TL;DR: The HERMES data were collected by the HERA storage ring using 27.6 GeV electron and positron beams incident on a hydrogen or deuterium gas target as discussed by the authors.
Abstract: Multiplicities in semi-inclusive deep-inelastic scattering are presented for each charge state of ${\ensuremath{\pi}}^{\ifmmode\pm\else\textpm\fi{}}$ and ${\mathrm{K}}^{\ifmmode\pm\else\textpm\fi{}}$ mesons. The data were collected by the HERMES experiment at the HERA storage ring using 27.6 GeV electron and positron beams incident on a hydrogen or deuterium gas target. The results are presented as a function of the kinematic quantities ${x}_{\mathrm{B}}$, ${Q}^{2}$, $z$, and ${P}_{h\ensuremath{\perp}}$. They represent a unique data set for identified hadrons that will significantly enhance our understanding of the fragmentation of quarks into final-state hadrons in deep-inelastic scattering.
173 citations
Authors
Showing all 775 results
Name | H-index | Papers | Citations |
---|---|---|---|
Luis M. Liz-Marzán | 132 | 616 | 61684 |
Maurizio Prato | 109 | 741 | 63055 |
Francisco Guinea | 108 | 573 | 69426 |
Rafael Yuste | 104 | 342 | 37415 |
Tom Broadhurst | 96 | 422 | 30074 |
Alexei Verkhratsky | 89 | 450 | 29788 |
Maria Forsyth | 84 | 749 | 33340 |
J. Garay Garcia | 81 | 348 | 23275 |
Ángel Borja | 77 | 316 | 20302 |
Wei Zhang | 76 | 1932 | 34966 |
Mirko Prato | 76 | 370 | 21189 |
Nate Bastian | 76 | 355 | 18342 |
A. J. Castro-Tirado | 72 | 728 | 24272 |
Rainer Hillenbrand | 71 | 227 | 18259 |
B. Andrei Bernevig | 69 | 280 | 29935 |