Institution
Ikerbasque
Other•Bilbao, Spain•
About: Ikerbasque is a other organization based out in Bilbao, Spain. It is known for research contribution in the topics: Graphene & Quantum. The organization has 713 authors who have published 7967 publications receiving 231990 citations. The organization is also known as: Basque Foundation for Science.
Topics: Graphene, Quantum, Population, Galaxy, Magnetization
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated here that a combination of state-of-the-art EDX mapping with electron tomography results in the unambiguous determination of both morphology transformation and elemental composition of nanostructures in 3D, during galvanic replacement of Ag nanocubes.
Abstract: Galvanic replacement reactions on metal nanoparticles are often used for the preparation of hollow nanostructures with tunable porosity and chemical composition, leading to tailored optical and catalytic properties. However, the precise interplay between the three-dimensional (3D) morphology and chemical composition of nanostructures during galvanic replacement is not always well understood as the 3D chemical imaging of nanoscale materials is still challenging. It is especially far from straightforward to obtain detailed information from the inside of hollow nanostructures using electron microscopy techniques such as SEM or TEM. We demonstrate here that a combination of state-of-the-art EDX mapping with electron tomography results in the unambiguous determination of both morphology transformation and elemental composition of nanostructures in 3D, during galvanic replacement of Ag nanocubes. This work provides direct and unambiguous experimental evidence toward understanding the galvanic replacement reaction. In addition, the powerful approach presented here can be applied to a wide range of nanoscale transformation processes, which will undoubtedly guide the development of novel nanostructures.
124 citations
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University of Geneva1, King Abdullah University of Science and Technology2, Institut national de la recherche agronomique3, Macquarie University4, Bangor University5, Kaiserslautern University of Technology6, University of Duisburg-Essen7, Cawthron Institute8, University of Auckland9, Polish Academy of Sciences10, Ikerbasque11
TL;DR: This paper aims to compare, review and discuss the strengths and limitations of four general implementation strategies of environmental genomics for monitoring, and proposes a roadmap for the implementation of environmentalgenomics into routine monitoring programmes that leverage recent analytical advancements.
Abstract: A decade after environmental scientists integrated high-throughput sequencing technologies in their toolbox, the genomics-based monitoring of anthropogenic impacts on the biodiversity and functioning of ecosystems is yet to be implemented by regulatory frameworks. Despite the broadly acknowledged potential of environmental genomics to this end, technical limitations and conceptual issues still stand in the way of its broad application by end-users. In addition, the multiplicity of potential implementation strategies may contribute to a perception that the routine application of this methodology is premature or "in development", hence restraining regulators from binding these tools into legal frameworks. Here, we review recent implementations of environmental genomics-based methods, applied to the biomonitoring of ecosystems. By taking a general overview, without narrowing our perspective to particular habitats or groups of organisms, this paper aims to compare, review and discuss the strengths and limitations of four general implementation strategies of environmental genomics for monitoring: (a) Taxonomy-based analyses focused on identification of known bioindicators or described taxa; (b) De novo bioindicator analyses; (c) Structural community metrics including inferred ecological networks; and (d) Functional community metrics (metagenomics or metatranscriptomics). We emphasise the utility of the three latter strategies to integrate meiofauna and microorganisms that are not traditionally utilised in biomonitoring because of difficult taxonomic identification. Finally, we propose a roadmap for the implementation of environmental genomics into routine monitoring programmes that leverage recent analytical advancements, while pointing out current limitations and future research needs.
124 citations
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TL;DR: This work shows that the control of ubiquitin dynamics at mitochondria contributes to the regulation of apoptotic cell death and suggests USP30 as a potential target for combinatorial anti‐cancer therapy.
Abstract: Mitochondria play a pivotal role in the orchestration of cell death pathways. Here, we show that the control of ubiquitin dynamics at mitochondria contributes to the regulation of apoptotic cell death. The unique mitochondrial deubiquitylase, USP30, opposes Parkin-dependent ubiquitylation of TOM20, and its depletion enhances depolarization-induced cell death in Parkin-overexpressing cells. Importantly, USP30 also regulates BAX/BAK-dependent apoptosis, and its depletion sensitizes cancer cells to BH3-mimetics. These results provide the first evidence for a fundamental role of USP30 in determining the threshold for mitochondrial cell death and suggest USP30 as a potential target for combinatorial anti-cancer therapy.
124 citations
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TL;DR: The long‐term clinical evolution of surgical PD patients with at least 5‐year follow-up seems to be associated with a new PD phenotype, mainly characterized by axial motor problems and cognitive impairment.
Abstract: The surgical lesion of different brain structures has been used as a treatment for Parkinson's disease (PD) for several decades More recently, the favored therapeutic approach has involved the administration of levodopa and the use of DBS These two major therapeutic advances have greatly modified both the clinical condition of patients and the history of the disease With the introduction of L-dopa in 1967, patients could regain mobility, because their akinesia, tremor, and rigidity were greatly improved, with consequent significant improvement in quality of life and increased life expectancy However, after the so-called “honeymoon” period in which the disease seemed to be controlled, motor fluctuations and L-dopa-induced dyskinesias mitigated the initial enthusiasm In the 1990s, unilateral pallidotomy and DBS of the globus palllidus internus and STN reduced these motor fluctuations and dyskinesias remarkably, thereby inaugurating a new era in the surgical treatment of PD Short- and medium-term follow-up studies of patients who underwent surgery have documented sustained, significant motor benefits However, given the progressive nature of PD and the purely symptomatic effects of pallidotomy and DBS, the long-term clinical evolution of these surgical patients currently seems to be associated with a new PD phenotype, mainly characterized by axial motor problems and cognitive impairment Here, we analyze the long-term clinical outcomes of surgical PD patients with at least 5-year follow-up, focusing on the long-term motor symptoms that were initially responsive to surgery © 2012 Movement Disorder Society
124 citations
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TL;DR: Spectroscopic analysis of infrared-resonant antenna probes for tip-enhanced optical microscopy corroborates their functionality as resonant antennas and verifies the broad tunability, and experimentally demonstrates high-performance mid-infrared nanoimaging of molecular absorption.
Abstract: We report the development of infrared-resonant antenna probes for tip-enhanced optical microscopy. We employ focused-ion-beam machining to fabricate high-aspect ratio gold cones, which replace the standard tip of a commercial Si-based atomic force microscopy cantilever. Calculations show large field enhancements at the tip apex due to geometrical antenna resonances in the cones, which can be precisely tuned throughout a broad spectral range from visible to terahertz frequencies by adjusting the cone length. Spectroscopic analysis of these probes by electron energy loss spectroscopy, Fourier transform infrared spectroscopy, and Fourier transform infrared near-field spectroscopy corroborates their functionality as resonant antennas and verifies the broad tunability. By employing the novel probes in a scattering-type near-field microscope and imaging a single tobacco mosaic virus (TMV), we experimentally demonstrate high-performance mid-infrared nanoimaging of molecular absorption. Our probes offer excellent...
124 citations
Authors
Showing all 775 results
Name | H-index | Papers | Citations |
---|---|---|---|
Luis M. Liz-Marzán | 132 | 616 | 61684 |
Maurizio Prato | 109 | 741 | 63055 |
Francisco Guinea | 108 | 573 | 69426 |
Rafael Yuste | 104 | 342 | 37415 |
Tom Broadhurst | 96 | 422 | 30074 |
Alexei Verkhratsky | 89 | 450 | 29788 |
Maria Forsyth | 84 | 749 | 33340 |
J. Garay Garcia | 81 | 348 | 23275 |
Ángel Borja | 77 | 316 | 20302 |
Wei Zhang | 76 | 1932 | 34966 |
Mirko Prato | 76 | 370 | 21189 |
Nate Bastian | 76 | 355 | 18342 |
A. J. Castro-Tirado | 72 | 728 | 24272 |
Rainer Hillenbrand | 71 | 227 | 18259 |
B. Andrei Bernevig | 69 | 280 | 29935 |