Imperial Chemical Industries

About: Imperial Chemical Industries is a based out in . It is known for research contribution in the topics: Alkyl & Catalysis. The organization has 8189 authors who have published 7809 publications receiving 190252 citations. The organization is also known as: Imperial Chemical Industries Ltd.

Desensitization of Beta Adrenergic Receptors in Human Fibroblasts in Tissue Culture

Abstract: The ability of isoproterenol, epinephrine, norepinephrine, and salbutamol to desensitize the beta receptor-coupled cyclic 39,59-AMP response of human diploid fibroblasts in tissue culture correlates well with their activity as beta stimulants. Partial desensitization of the cells results in a marked fall in the maximal cyclic AMP response to isoproterenol: fully desensitized cells are totally unresponsive to isoproterenol. Recovery of beta adrenergic sensitivity is a slow process and is delayed by extremely low concentrations of isoproterenol (picomolar). Recovery is also inhibited by concentrations of puromycin, cycloheximide, and actinomycin D that inhibit protein or RNA synthesis.

Treated non-woven material

Abstract: There is disclosed a non-woven material having a superficial coating of a linear polymeric biguanide in which the recurring unit is of the formula ##STR1## wherein X and Y, which may be the same or different, represent bridging groups in which the total number of carbon atoms in X and Y taken together, directly interposed between the pairs of nitrogen atoms linked thereby, is from 10 to 16, or the salt thereof with an acid. Preferably the polymeric biguanide is polyhexamethylene biguanide dihydrochloride. The material is useful in the form of an article designed for the collection of human body emissions, more particularly disposable nappies to avoid bacterial activity.

1-carbamoylalkyl phenoxy-3-amino-2-propanols

Abstract: NOVEL 1-(ELECTRONEGATIVELY-SUBSTITUTED-ALKYL- OR ALKENYLPHENOXY)-3-ALKYLAMINO-2-PROPANOL DERIVATIVES, FOR EXAMPLE 1-P-CARBAMOYLMETHYLPHENOXY-3-ISOPROPYLAMINO-2PROPANOL, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. THE COMPOUNDS POSSESS B-ADRENERGIC BLOCKING ACTIVITY AND ARE USEFUL IN THE TREATMENT OF HEART DISEASES AND OTHER COMPLAINTS IN MAN. THIS INVENTION RELATES TO NEW ALKANOLAMINE DERIVATIVES WHICH POSSESS B-ADRENERGIC BLOCKING ACTIVITY AND WHICH ARE THEREFORE USEFUL IN THE TREATMENT OR PROPHYLAXIS OF HEART DISEASES, FOR EXAMPLE ANGINA PECTORIS AND CARDIAC ARRHYTHMIAS, AND IN THE TREATMENT OF HYPERTENSION AND PHAEOCHROMOCYTOMA, IN MAN.