Imperial Chemical Industries

About: Imperial Chemical Industries is a based out in . It is known for research contribution in the topics: Alkyl & Catalysis. The organization has 8189 authors who have published 7809 publications receiving 190252 citations. The organization is also known as: Imperial Chemical Industries Ltd.

The inhibition of gastric acid secretion by epidermal growth factor.

Abstract: Le facteur de croissance epidermique (EGF) a ete isole a partir des glandes sous-maxillaires des souris. On a trouve que ce facteur est un inhibiteur de la secretion gastrique. Chez les chiens des doses aussi faibles que 0,1 μg/kg font baisser la secretion gastrique provoquee par divers stimulants.

The continuous‐flow gravity thickener: Steady state behavior

Abstract: The equations governing consolidation in a continuous-flow gravity thickener are developed based on the assumption that a flocculated suspension possesses a compressive yield stress Py(ϕ) that is a function of local volume fraction only. These equations are used to model the steady state operation of a thickener. The bed height required to achieve a given underflow concentration is found to be a relatively sensitive function of the details of the Py(ϕ) function, particle flux through the thickener, and variations in the cross-sectional area of the thickener. The limiting values of the underflow concentration ϕu for a given flux or the limiting values of flux for a desired ϕu are studied and shown to exist only for cylindrical and converging thickeners.

Chlorinated C1 and C2 hydrocarbons in the marine environment.

Abstract: A range of chlorinated hydrocarbons derived from C$_{1}$ and C$_{2}$ hydrocarbons is manufactured industrially They are used as intermediates for further chemical manufacture and also outside the chemical industry as solvents or carriers In the latter category losses in use are eventually dispersed to the environment The distribution of some of these compounds, including chloroform, carbon tetrachloride, trichloroethylene, perchloroethylene and trichloroethane, in the environment (air, water and marine sediments) has been investigated and the results are presented The concentrations found have been compared with acute toxicity levels to fish and other aquatic organisms, ascertained by laboratory bioassay The occurrence of the compounds has been determined in a number of marine organisms, especially those at higher trophic levels, and the accumulation of some of them has been investigated in the laboratory Chemical and microbial degradation processes have been studied in the laboratory to help determine the course of their removal from the aqueous and aerial environment, and the half lives of some of the compounds have been estimated It is concluded that these compounds are not persistent in the environment, and that there is no significant bioaccumulation in marine food chains

Resolution of the nonsteroidal antiandrogen 4'-cyano-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-3'- (trifluoromethyl)-propionanilide and the determination of the absolute configuration of the active enantiomer.

Abstract: The nonsteroidal antiandrogen 4'-cyano-3-[(4-fluorophenyl)sulfonyl]-2- hydroxy-2-methyl-3'-(trifluoromethyl)-propionanilide (1) (ICI 176334) has been resolved by chromatographic separation of the diastereomeric (R)-camphanyl esters of the precursor thioether 2 followed by hydrolysis and oxidation of the isolated enantiomers. In addition, an asymmetric synthesis of (S)-3-bromo-2-hydroxy-2-methylpropanoic acid (11) and subsequent conversion into the (S)-sulfone 6a has established that the more potent enantiomer of 1 has the R absolute configuration.