Imperial Chemical Industries

About: Imperial Chemical Industries is a based out in . It is known for research contribution in the topics: Alkyl & Catalysis. The organization has 8189 authors who have published 7809 publications receiving 190252 citations. The organization is also known as: Imperial Chemical Industries Ltd.

Thermotropic polyesters with non‐linear links

Abstract: The use of different linking units to promote liquid crystal behaviour in rigid rod like polyarylates is reviewed. By systematically varying the proportion of non linear, meta, ortho, or bent bisphenol units in one particular series based on chloro- 1,4 phenylene: 4,4′ oxydibenzoate/terephthalate, complete series of compositions, extending from liquid crystal through to isotropic behaviour, have been prepared, characterised and compared. Using this data, parallels between thermotropic and lyotropic behaviour are illustrated and used to postulate physical models for the structure of liquid crystalline melts and solids.

Novel treatment for joint inflammation

Abstract: THE use of liposomes in the entrappment and administration of several therapeutic agents has been described for the treatment of cancer1 and heavy metal poisoning2, and in enzyme replacement therapy3. The advantages of a liposome drug over the use of free or polymer-bound agent are decreased toxicity and degradation, the use of smaller doses and the possibility of targeting the liposome towards a given tissue or site4. The localised administration of therapeutic agents, such as the intra-articular injection of cortisol esters in the treatment of rheumatoid arthritis5, is a situation where the use of liposomes as a means of providing a stable particulate suspension of entrapped steroid might be used to advantage. This method should reduce considerably the effective dose required to produce relief, and diminish side effects due to escape of steroid from the joint6. We report here that the treatment of an acute experimental arthritis in the rabbit with a liposome preparation containing cortisol results in a significant reduction in joint temperature and diameter, whereas treatment with an equivalent amount of cortisol alone, or with liposomes lacking cortisol, does not reduce these two parameters of inflammation.