Instituto Superior Técnico

About: Instituto Superior Técnico is a based out in . It is known for research contribution in the topics: Catalysis & Finite element method. The organization has 10085 authors who have published 30226 publications receiving 667524 citations. The organization is also known as: IST & Instituto Superior Tecnico.

The effect of superplasticizers on the mechanical performance of concrete made with fine recycled concrete aggregates

Abstract: It is considered that using crushed recycled concrete as aggregate for concrete production is a viable alternative to dumping and would help to conserve abiotic resources. This use has fundamentally been based on the coarse fraction because the fine fraction is likely to degrade the performance of the resulting concrete. This paper presents results from a research work undertaken at Instituto Superior Tecnico (IST), Lisbon, Portugal, in which the effects of incorporating two types of superplasticizer on the mechanical performance of concrete containing fine recycled aggregate were evaluated. The purpose was to see if the addition of superplasticizer would offset the detrimental effects associated with the use of fine recycled concrete aggregate. The experimental programme is described and the results of tests for splitting tensile strength, modulus of elasticity and abrasion resistance are presented. The relative performance of concrete made with recycled aggregate was found to decrease. However, the same concrete with admixtures in general exhibited a better mechanical performance than the reference mixes without admixtures or with a less active superplasticizer. Therefore, it is argued that the mechanical performance of concrete made with fine recycled concrete aggregates can be as good as that of conventional concrete, if superplasticizers are used to reduce the water–cement ratio of the former concrete.

Nonlinear laser driven donut wakefields for positron and electron acceleration

Abstract: We show analytically and through three-dimensional particle-in-cell simulations that nonlinear wakefields driven by Laguerre-Gaussian laser pulses can lead to hollow electron self-injection and positron acceleration. We find that higher order lasers can drive donut shaped blowout wakefields with strong positron accelerating gradients comparable to those of a spherical bubble. Corresponding positron focusing forces can be more than an order of magnitude stronger than electron focusing forces in a spherical bubble. Required laser intensities and energies to reach the nonlinear donut shaped blowout are within state-of-the-art experimental conditions.

Network routing with path vector protocols: theory and applications

Abstract: Path vector protocols are currently in the limelight, mainly because the inter-domain routing protocol of the Internet, BGP (Border Gateway Protocol), belongs to this class. In this paper, we cast the operation of path vector protocols into a broad algebraic framework and relate the convergence of the protocol, and the characteristics of the paths to which it converges, with the monotonicity and isotonicity properties of its path compositional operation. Here, monotonicity means that the weight of a path cannot decrease when it is extended, and isotonicity means that the relationship between the weights of any two paths with the same origin is preserved when both are extended to the same node. We show that path vector protocols can be made to converge for every network if and only if the algebra is monotone, and that the resulting paths selected by the nodes are optimal if and only if the algebra is isotone as well.Many practical conclusions can be drawn from instances of the generic algebra. For performance-oriented routing, typical in intra-domain routing, we conclude that path vector protocols can be made to converge to widest or widest-shortest paths, but that the composite metric of IGRP (Interior Gateway Protocol), for example, does not guarantee convergence to optimal paths. For policy-based routing, typical in inter-domain routing, we formulate existing guidelines as instances of the generic algebra and we propose new ones. We also show how a particular instance of the algebra yields a sufficient condition for signaling correctness of internal BGP.

Robotic fluidic coupling and interrogation of multiple vascularized organ chips.

Abstract: Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an 'interrogator' that employs liquid-handling robotics, custom software and an integrated mobile microscope for the automated culture, perfusion, medium addition, fluidic linking, sample collection and in situ microscopy imaging of up to ten organ chips inside a standard tissue-culture incubator. The robotic interrogator maintained the viability and organ-specific functions of eight vascularized, two-channel organ chips (intestine, liver, kidney, heart, lung, skin, blood-brain barrier and brain) for 3 weeks in culture when intermittently fluidically coupled via a common blood substitute through their reservoirs of medium and endothelium-lined vascular channels. We used the robotic interrogator and a physiological multicompartmental reduced-order model of the experimental system to quantitatively predict the distribution of an inulin tracer perfused through the multi-organ human-body-on-chips. The automated culture system enables the imaging of cells in the organ chips and the repeated sampling of both the vascular and interstitial compartments without compromising fluidic coupling.