Iowa State University

About: Iowa State University is a education organization based out in Ames, Iowa, United States. It is known for research contribution in the topics: Population & Gene. The organization has 50151 authors who have published 107716 publications receiving 3355909 citations. The organization is also known as: Iowa State University of Science and Technology & Iowa State College.

DNA sequence quality trimming and vector removal

Abstract: MOTIVATION Most sequence comparison methods assume that the data being compared are trustworthy, but this is not the case with raw DNA sequences obtained from automatic sequencing machines Nevertheless, sequence comparisons need to be done on them in order to remove vector splice sites and contaminants This step is necessary before other genomic data processing stages can be carried out, such as fragment assembly or EST clustering A specialized tool is therefore needed to solve this apparent dilemma RESULTS We have designed and implemented a program that specifically addresses the problem This program, called LUCY, has been in use since 1998 at The Institute for Genomic Research (TIGR) During this period, many rounds of experience-driven modifications were made to LUCY to improve its accuracy and its ability to deal with extremely difficult input cases We believe we have finally obtained a useful program which strikes a delicate balance among the many issues involved in the raw sequence cleaning problem, and we wish to share it with the research community AVAILABILITY LUCY is available directly from TIGR (http://wwwtigrorg/softlab) Academic users can download LUCY after accepting a free academic use license Business users may need to pay a license fee to use LUCY for commercial purposes CONTACT Questions regarding the quality assessment module of LUCY should be directed to Michael Holmes (mholmes@tigrorg) Questions regarding other aspects of LUCY should be directed to Hui-Hsien Chou (hhchou@iastateedu)

Perceived Discrimination and Substance Use in African American Parents and Their Children: A Panel Study.

Abstract: The relation between perceived racial discrimination and substance use was examined in a panel of 684 African American families, using the prototype-willingness model of adolescent health risk (F. X. Gibbons, M. Gerrard, & D. Lane, 2003). Discrimination was concurrently and prospectively related to use in the parents and the children (mean age = 10.5 years at Wave 1). The discrimination → use relation in the parents was mediated by distress (anxiety and depression). Among the children, the relation was mediated by distress as well as their risk cognitions (favorability of their risk images and their willingness to use) and the extent to which they reported affiliating with friends who were using substances. Each of these relations with discrimination was positive. In contrast, effective parenting was associated with less willingness and intention to use. Theoretical and applied implications of the results are discussed.

Stimulus Sampling and Social Psychological Experimentation

Abstract: The authors discuss the problem with failing to sample stimuli in social psychological experimentation. Although commonly construed as an issue for external validity, the authors emphasize how failure to sample stimuli also can threaten construct validity. They note some circumstances where the need for stimulus sampling is less obvious and more obvious, and they discuss some well-known cognitive biases that can contribute to the failure of researchers to see the need for stimulus sampling. Data are presented from undergraduate students (N = 106), graduate students (N = 72), and psychology faculty (N = 48) showing insensitivity to the need for stimulus sampling except when the problem is made rather obvious. Finally, some of the statistical implications of stimulus sampling with particular concern for power, effect size estimates, and data analysis strategies are noted.

Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project

Abstract: The Minimum Information for Biological and Biomedical Investigations (MIBBI) project aims to foster the coordinated development of minimum-information checklists and provide a resource for those exploring the range of extant checklists.