Showing papers by "La Trobe University published in 2001"
TL;DR: The concept of I• and S•type granites was introduced in 1974 to account for the observation that, apart from the most felsic rocks, the granites in the Lachlan Fold Belt have properties that generally fall into two distinct groups as mentioned in this paper.
Abstract: The concept of I‐ and S‐type granites was introduced in 1974 to account for the observation that, apart from the most felsic rocks, the granites in the Lachlan Fold Belt have properties that generally fall into two distinct groups. This has been interpreted to result from derivation by partial melting of two kinds of source rocks, namely sedimentary and older igneous rocks. The original publication on these two granite types is reprinted and reviewed in the light of 25 years of continuing study into these granites.
1,175 citations
TL;DR: Osteopontin appears to regulate T helper cell–1 (TH1)–mediated demyelinating disease, and it may offer a potential target in blocking development of progressive MS.
Abstract: Multiple sclerosis is a demyelinating disease, characterized by inflammation in the brain and spinal cord, possibly due to autoimmunity. Large-scale sequencing of cDNA libraries, derived from plaques dissected from brains of patients with multiple sclerosis (MS), indicated an abundance of transcripts for osteopontin (OPN). Microarray analysis of spinal cords from rats paralyzed by experimental autoimmune encephalomyelitis (EAE), a model of MS, also revealed increased OPN transcripts. Osteopontin-deficient mice were resistant to progressive EAE and had frequent remissions, and myelin-reactive T cells in OPN-/- mice produced more interleukin 10 and less interferon-gamma than in OPN+/+ mice. Osteopontin thus appears to regulate T helper cell-1 (TH1)-mediated demyelinating disease, and it may offer a potential target in blocking development of progressive MS.
848 citations
TL;DR: Ankle injuries occurred at a rate of 3.85 per 1000 participations, with almost half (45.9%) of the ankle injured basketball players missing one week or more of competition and the most common mechanism being landing.
Abstract: Objectives —To determine the rate of ankle injury and examine risk factors of ankle injuries in mainly recreational basketball players. Methods —Injury observers sat courtside to determine the occurrence of ankle injuries in basketball. Ankle injured players and a group of non-injured basketball players completed a questionnaire. Results —A total of 10 393 basketball participations were observed and 40 ankle injuries documented. A group of non-injured players formed the control group (n = 360). The rate of ankle injury was 3.85 per 1000 participations, with almost half (45.9%) missing one week or more of competition and the most common mechanism being landing (45%). Over half (56.8%) of the ankle injured basketball players did not seek professional treatment. Three risk factors for ankle injury were identified: (1) players with a history of ankle injury were almost five times more likely to sustain an ankle injury (odds ratio (OR) 4.94, 95% confidence interval (CI) 1.95 to 12.48); (2) players wearing shoes with air cells in the heel were 4.3 times more likely to injure an ankle than those wearing shoes without air cells (OR 4.34, 95% CI 1.51 to 12.40); (3) players who did not stretch before the game were 2.6 times more likely to injure an ankle than players who did (OR 2.62, 95% CI 1.01 to 6.34). There was also a trend toward ankle tape decreasing the risk of ankle injury in players with a history of ankle injury (p = 0.06). Conclusions —Ankle injuries occurred at a rate of 3.85 per 1000 participations. The three identified risk factors, and landing, should all be considered when preventive strategies for ankle injuries in basketball are being formulated.
686 citations
TL;DR: In this article, the authors report an extensive field-based study of zircon and monazite in the metamorphic sequence of the Reynolds Range (central Australia), where greenschist-to granulite-facies metamorphism is recorded over a continuous crustal section.
Abstract: We report an extensive field-based study of zircon and monazite in the metamorphic sequence of the Reynolds Range (central Australia), where greenschist- to granulite-facies metamorphism is recorded over a continuous crustal section. Detailed cathodoluminescence and back-scattered electron imaging, supported by SHRIMP U–Pb dating, has revealed the different behaviours of zircon and monazite during metamorphism. Monazite first recorded regional metamorphic ages (1576 ± 5 Ma), at amphibolite-facies grade, at ∼600 °C. Abundant monazite yielding similar ages (1557 ± 2 to 1585 ± 3 Ma) is found at granulite-facies conditions in both partial melt segregations and restites. New zircon growth occurred between 1562 ± 4 and 1587 ± 4 Ma, but, in contrast to monazite, is only recorded in granulite-facies rocks where melt was present (≥700 °C). New zircon appears to form at the expense of pre-existing detrital and inherited cores, which are partly resorbed. The amount of metamorphic growth in both accessory minerals increases with temperature and metamorphic grade. However, new zircon growth is influenced by rock composition and driven by partial melting, factors that appear to have little effect on the formation of metamorphic monazite. The growth of these accessory phases in response to metamorphism extends over the 30 Ma period of melt crystallisation (1557–1587 Ma) in a stable high geothermal regime. Rare earth element patterns of zircon overgrowths in leucosome and restite indicate that, during the protracted metamorphism, melt-restite equilibrium was reached. Even in the extreme conditions of long-lasting high temperature (750–800 °C) metamorphism, Pb inheritance is widely preserved in the detrital zircon cores. A trace of inheritance is found in monazite, indicating that the closure temperature of the U–Pb system in relatively large monazite crystals can exceed 750–800 °C.
611 citations
TL;DR: Retest reliability and interrater reliability of the TUG measurements were high, and the measurements reflected changes in performance according to levodopa use.
Abstract: Background and Purpose. The Timed “Up & Go” Test (TUG) is used to measure the ability of patients to perform sequential locomotor tasks that incorporate walking and turning. This study investigated the retest reliability, interrater reliability, and sensitivity of TUG scores in detecting changes in mobility in subjects with idiopathic Parkinson disease (PD). Subjects. The performance of 12 people with PD was compared with that of 12 age-matched comparison subjects without PD. Methods. The subjects with PD completed 5 trials of the TUG after withdrawal of levodopa for 12 hours (“off” phase of the medication cycle) as well as an additional 5 trials 1 hour after levodopa was administered (“on” phase of the medication cycle). They were scored on the Modified Webster Scale at both sessions. The comparison subjects also performed 5 TUG trials. All trials were videotaped and timed by 2 experienced raters. The videotape was later rated by 3 experienced clinicians and 3 inexperienced clinicians. Results. For the subjects with PD, within-session performance was highly consistent, with correlations ( r ) ranging from .80 to .98 for the “off” phase and from .73 to .99 for the “on” phase. The performance of the comparison subjects across the 5 trials was also highly consistent ( r =.90–.97). Comparisons showed differences between trials 1 and 2 on the TUG for both groups. Removal of data for trial 1 (the practice trial) further enhanced retest reliability. There was close agreement in TUG scores among raters despite different levels of experience (intraclass correlation coefficient [3,1]=.87–.99). Mean TUG scores were different between the “on” and “off” phases of the levodopa cycle and between subjects with PD and comparison subjects during the “on” phase. Conclusion and Discussion. Retest reliability and interrater reliability of the TUG measurements were high, and the measurements reflected changes in performance according to levodopa use. The TUG can also be used to detect differences in performance between people with PD and elderly people without PD.
603 citations
TL;DR: The translocase of the outer mitochondrial membrane (TOM) is composed of receptors, a channel protein, and its modulators that function together to import proteins into mitochondria.
Abstract: The translocase of the outer mitochondrial membrane (TOM) is composed of receptors, a channel protein, and its modulators that function together to import proteins into mitochondria. Although the import pathway of proteins directed to the mitochondrial matrix has been well characterized, recent studies into the import pathway taken by proteins into the other submitochondrial compartments have broadened our understanding into the way the TOM machinery recognizes, interacts, and translocates proteins.
502 citations
TL;DR: Key activities for GM-CSF are revealed in the development of inflammatory demyelinating lesions and control of migration and/or proliferation of leukocytes within the CNS, which hold implications for the pathogenesis of inflammatory and demYelinating diseases.
Abstract: Experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis, can be induced by immunization with a number of myelin antigens. In particular, myelin oligodendrocyte glycoprotein, a central nervous system (CNS)-specific antigen expressed on the myelin surface, is able to induce a paralytic MS-like disease with extensive CNS inflammation and demyelination in several strains of animals. Although not well understood, the egress of immune cells into the CNS in EAE is governed by a complex interplay between pro and antiinflammatory cytokines and chemokines. The hematopoietic growth factor, granulocyte macrophage colony-stimulating factor (GM-CSF), is considered to play a central role in maintaining chronic inflammation. The present study was designed to investigate the previously unexplored role of GM-CSF in autoimmune-mediated demyelination. GM-CSF(-/)- mice are resistant to EAE, display decreased antigen-specific proliferation of splenocytes, and fail to sustain immune cell infiltrates in the CNS, thus revealing key activities for GM-CSF in the development of inflammatory demyelinating lesions and control of migration and/or proliferation of leukocytes within the CNS. These results hold implications for the pathogenesis of inflammatory and demyelinating diseases and may provide the basis for more effective therapies for inflammatory diseases, and more specifically for multiple sclerosis.
495 citations
TL;DR: This work reports burial ages for megafauna from 28 sites and infer extinction across the continent around 46,400 years ago, ruling out extreme aridity at the Last Glacial Maximum as the cause of extinction, but not other climatic impacts; a "blitzkrieg" model of human-induced extinction; or an extended period of anthropogenic ecosystem disruption.
Abstract: All Australian land mammals, reptiles, and birds weighing more than 100 kilograms, and six of the seven genera with a body mass of 45 to 100 kilograms, perished in the late Quaternary. The timing and causes of these extinctions remain uncertain. We report burial ages for megafauna from 28 sites and infer extinction across the continent around 46,400 years ago (95% confidence interval, 51,200 to 39,800 years ago). Our results rule out extreme aridity at the Last Glacial Maximum as the cause of extinction, but not other climatic impacts; a "blitzkrieg" model of human-induced extinction; or an extended period of anthropogenic ecosystem disruption.
485 citations
TL;DR: In this article, the authors discuss four reasons for promoting use of confidence intervals: they are readily interpretable, are linked to familiar statistical significance tests, can encourage meta-analytic thinking, and give information about precision.
Abstract: Reform of statistical practice in the social and behavioral sciences requires wider use of confidence intervals (CIs), effect size measures, and meta-analysis. The authors discuss four reasons for promoting use of CIs: They (a) are readily interpretable, (b) are linked to familiar statistical significance tests, (c) can encourage meta-analytic thinking, and (d) give information about precision. The authors discuss calculation of CIs for a basic standardized effect size measure, Cohen’s δ (also known as Cohen’s d), and contrast these with the familiar CIs for original score means. CIs for δ require use of noncentral t distributions, which the authors apply also to statistical power and simple meta-analysis of standardized effect sizes. They provide the ESCI graphical software, which runs under Microsoft Excel, to illustrate the discussion. Wider use of CIs for δ and other effect size measures should help promote highly desirable reform of statistical practice in the social sciences.
483 citations
TL;DR: The authors found that recasts appear to be most effective in contexts where it is clear to the learner that the recast is a reaction to the accuracy of the form, not the content, of the original utterance.
Abstract: Some researchers suggest that recasts are effective in showing learners how their current interlanguage differs from the target (Long & Robinson, 1998). Others have argued that recasts are ambiguous and may be perceived by the learner as confirmation of meaning rather than feedback on form (Lyster, 1998a). We review research on the effectiveness of recasts in first and second language acquisition, paying particular attention to how recasts have been defined and how their impact has been assessed in observational and experimental studies. We conclude that recasts appear to be most effective in contexts where it is clear to the learner that the recast is a reaction to the accuracy of the form, not the content, of the original utterance.
469 citations
TL;DR: A potent inhibitory effect on the growth and development of larvae from the Lepidopteran species Helicoverpa punctigera is described, indicating that the cyclotide domains are excised and cyclized from all four predicted precursor proteins.
Abstract: Several members of the Rubiaceae and Violaceae families produce a series of cyclotides or macrocyclic peptides of 29–31 amino acids with an embedded cystine knot. We aim to understand the mechanism of synthesis of cyclic peptides in plants and have isolated a cDNA clone that encodes the cyclotide kalata B1 as well as three other clones for related cyclotides from the African plant Oldenlandia affinis. The cDNA clones encode prepropeptides with a 20-aa signal sequence, an N-terminal prosequence of 46–68 amino acids and one, two, or three cyclotide domains separated by regions of about 25 aa. The corresponding cyclotides have been isolated from plant material, indicating that the cyclotide domains are excised and cyclized from all four predicted precursor proteins. The exact processing site is likely to lie on the N-terminal side of the strongly conserved GlyLeuPro or SerLeuPro sequence that flanks both sides of the cyclotide domain. Cyclotides have previously been assigned an antimicrobial function; here we describe a potent inhibitory effect on the growth and development of larvae from the Lepidopteran species Helicoverpa punctigera.
TL;DR: Overall, demoralization syndrome has satisfactory face, descriptive, predictive, construct, and divergent validity, suggesting its utility as a diagnostic category in palliative care.
Abstract: Hopelessness, loss of meaning, and existential distress are proposed as the core features of the diagnostic category of demoralization syndrome. This syndrome can be differentiated from depression and is recognizable in palliative care settings. It is associated with chronic medical illness, disability, bodily disfigurement, fear of loss of dignity, social isolation, and--where there is a subjective sense of incompetence--feelings of greater dependency on others or the perception of being a burden. Because of the sense of impotence or helplessness, those with the syndrome predictably progress to a desire to die or to commit suicide. A treatment approach is described which has the potential to alleviate the distress caused by this syndrome. Overall, demoralization syndrome has satisfactory face, descriptive, predictive, construct, and divergent validity, suggesting its utility as a diagnostic category in palliative care.
TL;DR: Most of the children in the study will reach a level of over 90% sentence recognition in the auditory-visual condition when their language becomes equivalent to that of a normally hearing 7-year-old, but they will enter secondary school at age 12 with an average language delay of about 4 or 5 years unless they receive concentrated and effective language training.
Abstract: Eighty-seven primary-school children with impaired hearing were evaluated using speech perception, production, and language measures over a 3-year period. Forty-seven children with a mean unaided p...
TL;DR: The detection of emotion recognition impairments in first-episode schizophrenia suggests a trait deficit, and the pattern of results is consistent with amygdala dysfunction in schizophrenia and related psychoses.
TL;DR: The first case describes the kinematic gait response of an individual with Parkinson disease to visual cues in the "off" phase of the levodopa medication cycle and the second case investigates the biomechanics and motor control of turning during walking in a patient with Parkinson Disease compared with elderly and young control subjects.
TL;DR: There was little evidence that active therapeutic ultrasound is more effective than placebo ultrasound for treating people with pain or a range of musculoskeletal injuries or for promoting soft tissue healing.
Abstract: Background and Purpose. Therapeutic ultrasound is one of the most widely and frequently used electrophysical agents. Despite over 60 years of clinical use, the effectiveness of ultrasound for treating people with pain, musculoskeletal injuries, and soft tissue lesions remains questionable. This article presents a systematic review of randomized controlled trials (RCTs) in which ultrasound was used to treat people with those conditions. Each trial was designed to investigate the contributions of active and placebo ultrasound to the patient outcomes measured. Depending on the condition, ultrasound (active and placebo) was used alone or in conjunction with other interventions in a manner designed to identify its contribution and distinguish it from those of other interventions. Methods. Thirty-five English-language RCTs were published between 1975 and 1999. Each RCT identified was scrutinized for patient outcomes and methodological adequacy. Results. Ten of the 35 RCTs were judged to have acceptable methods using criteria based on those developed by Sackett et al. Of these RCTs, the results of 2 trials suggest that therapeutic ultrasound is more effective in treating some clinical problems (carpal tunnel syndrome and calcific tendinitis of the shoulder) than placebo ultrasound, and the results of 8 trials suggest that it is not. Discussion and Conclusion. There was little evidence that active therapeutic ultrasound is more effective than placebo ultrasound for treating people with pain or a range of musculoskeletal injuries or for promoting soft tissue healing. The few studies deemed to have adequate methods examined a wide range of patient problems. The dosages used in these studies varied considerably, often for no discernable reason.
TL;DR: It is shown that parasite‐derived structures, known as Maurer's clefts, are an elaboration of the canonical secretory pathway that is transposed outside the parasite into the host cell, the first example of its kind in eukaryotic biology.
Abstract: After invading human erythrocytes, the malarial parasite Plasmodium falciparum, initiates a remarkable process of secreting proteins into the surrounding erythrocyte cytoplasm and plasma membrane. One of these exported proteins, the knob-associated histidine-rich protein (KAHRP), is essential for microvascular sequestration, a strategy whereby infected red cells adhere via knob structures to capillary walls and thus avoid being eliminated by the spleen. This cytoadherence is an important factor in many of the deaths caused by malaria. Green fluorescent protein fusions and fluorescence recovery after photobleaching were used to follow the pathway of KAHRP deployment from the parasite endomembrane system into an intermediate depot between parasite and host, then onwards to the erythrocyte cytoplasm and eventually into knobs. Sequence elements essential to individual steps in the pathway are defined and we show that parasite-derived structures, known as Maurer's clefts, are an elaboration of the canonical secretory pathway that is transposed outside the parasite into the host cell, the first example of its kind in eukaryotic biology.
TL;DR: A review of the existing literature on adventure tourism reveals that research on this subject has so far focused mainly on preconceived notions of scholars and practitioners as mentioned in this paper and argues that individuals' subjective experience of adventure and their perceptions of what constitutes it have to be also researched and considered in the study of adventure tourism.
29 Oct 2001
TL;DR: In this paper, the authors present a comparison of population means and isotonic regression for chi-bar-square distributions. But they do not consider whether the distribution is a normal distribution.
Abstract: Dedication. Preface. 1. Introduction. 1.1 Preamble. 1.2 Examples. 1.3 Coverage and Organization of the Book. 2. Comparison of Population Means and Isotonic Regression. 2.1 Ordered Hypothesis Involving Population Means. 2.2 Test of Inequality Constraints. 2.3 Isotonic Regression. 2.4 Isotonic Regression: Results Related to Computational Formulas. 3. Two Inequality Constrained Tests on Normal Means. 3.1 Introduction. 3.2 Statement of Two General Testing Problems. 3.3 Theory: The Basics in 2 Dimensions. 3.4 Chi-bar-square Distribution. 3.5 Computing the Tail Probabilities of chi-bar-square Distributions. 3.6 Detailed Results relating to chi-bar-square Distributions. 3.7 LRT for Type A Problems: V is known. 3.8 LRT for Type B Problems: V is known. 3.9 Inequality Constrained Tests in the Linear Model. 3.10 Tests When V is known. 3.11 Optimality Properties. 3.12 Appendix 1: Convex Cones. 3.13 Appendix B. Proofs. 4. Tests in General Parametric Models. 4.1 Introduction. 2.2 Preliminaries. 4.3 Tests of Rtheta = 0 against Rtheta 0. 4.4 Tests of h(theta) = 0. 4.5 An Overview of Score Tests with no Inequality Constraints. 4.6 Local Score-type Tests of Ho : psi = 0 vs H1 : psi &epsis PSI. 4.7 Approximating Cones and Tangent Cones. 4.8 General Testing Problems. 4.9 Properties of the mle When the True Value is on the Boundary. 5. Likelihood and Alternatives. 5.1 Introduction. 5.2 The Union-Intersection principle. 5.3 Intersection Union Tests (IUT). 5.4 Nanparametrics. 5.5 Restricted Alternatives and Simes-type Procedures. 5.6 Concluding Remarks. 6. Analysis of Categorical Data. 6.1 Motivating Examples. 6.2 Independent Binomial Samples. 6.3 Odds Ratios and Monotone Dependence. 6.4 Analysis of 2 x c Contingency Tables. 6.5 Test to Establish that Treatment is Better than Control. 6.6 Analysis of r x c Tables. 6.7 Square Tables and Marginal Homogeneity. 6.8 Exact Conditional Tests. 6.9 Discussion. 7. Beyond Parametrics. 7.1 Introduction. 7.2 Inference on Monotone Density Function. 7.3 Inference on Unimodal Density Function. 7.4 Inference on Shape Constrained Hazard Functionals. 7.5 Inference on DMRL Functions. 7.6 Isotonic Nonparametric Regression: Estimation. 7.7 Shape Constraints: Hypothesis Testing. 8. Bayesian Perspectives. 8.1 Introduction. 8.2 Statistical Decision Theory Motivations. 8.3 Stein's Paradox and Shrinkage Estimation. 8.4 Constrained Shrinkage Estimation. 8.5 PC and Shrinkage Estimation in CSI. 8.6 Bayes Tests in CSI. 8.7 Some Decision Theoretic Aspects: Hypothesis Testing. 9. Miscellaneous Topics. 9.1 Two-sample Problem with Multivariate Responses. 9.2 Testing that an Identified Treatment is the Best: The mini-test. 9.3 Cross-over Interaction. 9.4 Directed Tests. Bibliography. Index.
TL;DR: Earlier studies of GA signaling in the Gramineae are extended to include a dicot species, Arabidopsis, and indicate that GAMYB-like genes may mediateGA signaling in growth and flowering responses.
Abstract: We have identified three Arabidopsis genes with GAMYB-like activity, AtMYB33, AtMYB65, and AtMYB101, which can substitute for barley (Hordeum vulgare) GAMYB in transactivating the barley alpha-amylase promoter. We have investigated the relationships between gibberellins (GAs), these GAMYB-like genes, and petiole elongation and flowering of Arabidopsis. Within 1 to 2 d of transferring plants from short- to long-day photoperiods, growth rate and erectness of petioles increased, and there were morphological changes at the shoot apex associated with the transition to flowering. These responses were accompanied by accumulation of GAs in the petioles (GA(1) by 11-fold and GA(4) by 3-fold), and an increase in expression of AtMYB33 at the shoot apex. Inhibition of GA biosynthesis using paclobutrazol blocked the petiole elongation induced by long days. Causality was suggested by the finding that, with GA treatment, plants flowered in short days, AtMYB33 expression increased at the shoot apex, and the petioles elongated and grew erect. That AtMYB33 may mediate a GA signaling role in flowering was supported by its ability to bind to a specific 8-bp sequence in the promoter of the floral meristem-identity gene, LEAFY, this same sequence being important in the GA response of the LEAFY promoter. One or more of these AtMYB genes may also play a role in the root tip during germination and, later, in stem tissue. These findings extend our earlier studies of GA signaling in the Gramineae to include a dicot species, Arabidopsis, and indicate that GAMYB-like genes may mediate GA signaling in growth and flowering responses.
TL;DR: The results show that fast-growing cells of N-limited M. aeruginosa are smaller, are of lower mass, and have a higher intracellular MCYST quota and concentration than slow- growing cells.
Abstract: Cell quotas of microcystin (QMCYST; femtomoles of MCYST per cell), protein, and chlorophyll a (Chl a), cell dry weight, and cell volume were measured over a range of growth rates in N-limited chemostat cultures of the toxic cyanobacterium Microcystis aeruginosa MASH 01-A19. There was a positive linear relationship between QMCYST and specific growth rate (m), from which we propose a generalized model that enables QMCYST at any nutrient-limited growth rate to be predicted based on a single batch culture experiment. The model predicts QMCYST from m, mmax (maximum specific growth rate), QMCYSTmax (maximum cell quota), and QMCYSTmin (minimum cell quota). Under the conditions examined in this study, we predict a QMCYSTmax of 0.129 fmol cell 21 at mmax and a QMCYSTmin of 0.050 fmol cell 21 at m5 0. Net MCYST production rate (RMCYST) asymptotes to zero at m5 0 and reaches a maximum of 0.155 fmol cell 21 day 21 at mmax. MCYST/dry weight ratio (milligrams per gram [dry weight]) increased linearly with m, whereas the MCYST/protein ratio reached a maximum at intermediate m. In contrast, the MCYST/Chl a ratio remained constant. Cell volume correlated negatively with m, leading to an increase in intracellular MCYST concentration at high m. Taken together, our results show that fast-growing cells of N-limited M. aeruginosa are smaller, are of lower mass, and have a higher intracellular MCYST quota and concentration than slow-growing cells. The data also highlight the importance of determining cell MCYST quotas, as potentially confusing interpretations can arise from determining MCYST content as a ratio to other cell components.
TL;DR: This paper measured the strength of endorsements for ingroup leaders who varied in both their relative ingroup prototypicality and distributive intergroup fairness and found that leaders high in ingroupotypicality received strong endorsements from high identifiers regardless of the leaders' ingroup-favoring, outgroup-favorable, or fair intergroup behavior.
Abstract: This study (N = 216) measured the strength of endorsements for ingroup leaders who varied in both their relative ingroup prototypicality and distributive intergroup fairness. Leadership endorsement overall was positively related to group members’ levels of social identification and negatively related to their levels of reported self-interest. Among low identifiers, however, leaders’ distributive behavior reliably predicted endorsements, with stronger endorsements provided for distributively fair than unfair leaders. Among high identifiers, in contrast, both leaders’ distributive behavior and relative ingroup prototypicality were important. Leaders high in ingroup prototypicality received strong endorsements from high identifiers regardless of the leaders’ ingroup-favoring, outgroup-favoring, or fair intergroup behavior. Leaders low in ingroup prototypicality and who were relatively similar to the outgroup received strong endorsements from high identifiers only when the leaders made ingroup-favoring distributions. These data are interpreted within a social identity theory framework.
TL;DR: A systematic review of the literature on the management of upper limb dysfunction in children with cerebral palsy and a close examination of two relatively new treatments for upper limb spasticity, constraint induced movement therapy and botulinum toxin type A (BTX‐A) was conducted.
Abstract: Effective use of the upper limb can impact on educational outcomes, participation in activities of daily living and vocational options for many children with cerebral palsy (CP). This article presents the results of a systematic review of the literature on the management of upper limb dysfunction in children with CP. The range of management options includes therapies such as physiotherapy, occupational therapy, neurodevelopmental therapy and conductive education; peripheral splinting and casting; focal or generalized pharmacotherapy; and surgery to improve upper limb function or correct deformity. A literature search identified 60 papers, of which four were randomized controlled trials and 44 were prospective studies with objective outcome measures. Principal studies undertaken for each type of treatment and the efficacy of the different types of treatment were critically evaluated. In addition, the current level of evidence for each study was evaluated according to Sackett’s (1989) model and ICIDH-2 classification. A close examination of two relatively new treatments for upper limb spasticity, constraint induced movement therapy and botulinum toxin type A (BTX-A) was conducted with reference to more extensive data on the efficacy of BTX-A in the lower limb.
TL;DR: In this article, the authors test the hypothesis that support for leaders is enhanced when their decisions affirm a distinct social identity that is shared with followers, and find that participants showed less support for a leader who favored ingroup members who were relatively sympathetic to an outgroup position than for one who opposed an out-group position.
Abstract: Two experiments test the hypothesis that support for leaders is enhanced when their decisions affirm a distinct social identity that is shared with followers. In Experiment 1, participants showed less support for a leader who favored ingroup members who were relatively sympathetic to an outgroup position than for one who favored ingroup members who opposed an outgroup position. This finding was replicated in Experiment 2, which also showed that this pattern extended to support for the leader’s novel plans. Although participants indicated that they supported a leader who behaved evenhandedly toward all ingroup members as much as one whose behavior was identity-affirming, they were unwilling to back up the evenhanded leader with written comments and arguments. These data suggest that leaders’ capacity to engender active followership is contingent on their ability to promote collective interests associated with a shared ingroup identity.
TL;DR: Although tunnel enlargement is more common and greater with HS grafts, it does not appear to affect the clinical outcome in the first 2 postoperative years.
Abstract: Radiographic tibial and femoral bone tunnel enlargement has been demonstrated following anterior cruciate ligament (ACL) reconstruction. This study investigated whether bone tunnel enlargement differs between four-strand hamstring (HS) and patellar tendon (PT) ACL reconstructions over the course of a 2-year follow-up. Patients undergoing primary ACL reconstruction (n=65) were randomised to receive either a PT or HS autograft. Femoral fixation in both groups was by means of an Endobutton. On the tibial side the PT grafts were fixed using a metallic interference screw, and the HS tendons by sutures tied to a fixation post. The PT grafts were inserted such that the proximal end of the distal bone block was within 10 mm of the tibial articular surface, resulting in a portion of free patellar tendon in the femoral tunnel immediately proximal to the articular surface. Patients were reviewed after 4 months and 1 and 2 years. Tunnel enlargement was determined by measuring the widths of the femoral and tibial tunnels with a digital caliper in both lateral and anteroposterior radiographs. Because of the presence of the interference screw and the proximity of the bone block to the tibial articular surface, the tibial tunnel could not be reliably measured in the PT group. Measurements were corrected for magnification, and changes in tunnel width were recorded relative to the diameters drilled at surgery. Standard clinical measures were also noted. In 32% of patients in the PT group there was femoral tunnel obliteration from 4 months onwards. For the other patients there was a significantly greater increase in femoral tunnel width in the HS group than in the PT group at each follow-up, but no significant change with time. There was also a marked increase in tibial tunnel width in the HS group at 4 months but not thereafter. There was no relationship between tunnel enlargement and clinical measurements. Although tunnel enlargement is more common and greater with HS grafts, it does not appear to affect the clinical outcome in the first 2 postoperative years. Femoral suspensory fixation does not in itself appear to be the principal cause of femoral tunnel enlargement, at least for PT grafts.
TL;DR: The problems associated with cognitive assessment of people with sports related cognitive deficits are described, and the utility of conventional neuropsychological and computerised cognitive tests in sporting settings are critically examined.
Abstract: Professional and amateur participants in many sports are at risk of brain injury caused by impact with other players or objects. In many cases, mild cognitive deficits may persist after the common neurological signs of brain injury have passed. In recent years, the athlete's cognitive status after concussion has been measured with conventional "paper and pencil" neuropsychological tests. However, such tests are not ideal for sporting settings, as they are designed for the detection of gross cognitive impairments at a single assessment, not for the identification of mild cognitive deficits on repeated assessment. A number of computerised cognitive assessment tests and test batteries have been developed over the past two decades. These batteries offer major scientific and practical advantages over conventional neuropsychological tests which make them ideal for the assessment of cognitive function in sportspeople. This review first describes the problems associated with cognitive assessment of people with sports related cognitive deficits, and then critically examines the utility of conventional neuropsychological and computerised cognitive tests in sporting settings.
Key Words: cognitive assessment; head; injury; concussion; computerised; neuropsychology
TL;DR: In this article, the role of classroom discipline in promoting student responsibility for the protection of learning and safety rights in the classroom was examined in 21 elementary and 21 secondary schools, and the results indicated that teachers are seen by students to react to classroom misbehavior by increasing their use of coercive discipline, which inhibits the development of responsibility in students and distracts them from their schoolwork.
TL;DR: In this article, the relationship between partial melting and granite intrusion in a classic Barrovian metamorphic terrane has been assessed using SHRIMP U-Pb zircon geochronology from the island of Naxos, Greece.
TL;DR: A modification of Gentile s Taxonomy of Tasks is suggested for analysis of clinical balance tests, some of which are used as examples.
Abstract: Although balance control is an integral component of all daily activities, its complex and flexible nature makes it difficult to assess adequately. This paper discusses balance by examining it in relation to function and the physical environment. Balance is affected by both the task being undertaken and the surroundings in which it is performed. Different tasks and environments alter the biomechanical and information processing needs for balance control. These issues are discussed and a modification of Gentile's taxonomy of tasks is suggested for analysis of clinical balance tests, some of which are used as examples.
TL;DR: A new concept for import of the hydrophobic carrier proteins into mitochondria where multiple signals cooperate in receptor recruitment, outer membrane translocation via loop formation and assembly in the inner membrane is proposed.
Abstract: The ADP/ATP carrier (AAC) is a major representative of mitochondrial preproteins lacking an N-terminal presequence. AAC contains targeting information in each of its three modules, which has led to a search for the dominant targeting region. An alternative, not yet tested model would be that several distinct targeting signals function simultaneously in import of the preprotein. We report that the three AAC modules cooperate in binding to the receptor Tom70 such that three Tom70 dimers are recruited to one preprotein. The modules are transferred to the import pore in a stepwise manner and cooperate again in the accumulation of AAC in the general import pore complex. AAC can cross the outer membrane with an internal segment first, i.e. in a loop formation. Each module of AAC is required for dimerization in the inner membrane. We propose a new concept for import of the hydrophobic carrier proteins into mitochondria where multiple signals cooperate in receptor recruitment, outer membrane translocation via loop formation and assembly in the inner membrane.