Mahidol University International College

About: Mahidol University International College is a based out in . It is known for research contribution in the topics: Tourism & Corporate governance. The organization has 240 authors who have published 485 publications receiving 6095 citations.

PWYW Entrance fees: a visitor’s perspective on a prominent art museum in Thailand

Abstract: The pay-what-you-want (PWYW) strategy is attracting increasing attention from various industries. The tourism industry, especially cultural services and museums, has adopted this payment mechanism ...

Do bank-affiliated funds perform better than the others: the higher moment approach

Abstract: In this study, we examine the difference in mutual fund performance between the bank-related and the non-bank-related mutual funds in emerging markets. We further improve the empirical test...

Young People, Big Voices, Bangkok Noi: a participatory street photography project for connecting youth to a traditional community in a changing Bangkok

Abstract: This paper describes a participatory project aimed at understanding how young people identify with where they live, a village called Ban Bu in a sub-district of Bangkok called Bangkok Noi. The vill...

In silico investigation of mitragynine and 7-hydroxymitragynine metabolism.

Abstract: Mitragynine is the main active compound of Mitragyna speciose (Kratom in Thai). The understanding of mitragynine derivative metabolism in human body is required to develop effective detection techniques in case of drug abuse or establish an appropriate dosage in case of medicinal uses. This in silico study is based upon in vivo results in rat and human by Philipp et al. (J Mass Spectrom 44:1249–1261, 2009). Gas-phase structures of mitragynine, 7-hydroxymitragynine and their metabolites were obtained by quantum chemical method at B3LYP/6-311++G(d,p) level. Results in terms of standard Gibbs energies of reaction for all metabolic pathways are reported with solvation energy from SMD model. We found that 7-hydroxy substitution leads to changes in reactivity in comparison to mitragynine: position 17 is more reactive towards demethylation and conjugation with glucuronic acid and position 9 is less reactive towards conjugation with glucuronic acid. Despite the changes, position 9 is the most reactive for demethylation and position 17 is the most reactive for conjugation with glucuronic acid for both mitragynine and 7-hydroxymitragynine. Our results suggest that 7-hydroxy substitution could lead to different metabolic pathways and raise an important question for further experimental studies of this more potent derivative.