Nanyang Technological University

About: Nanyang Technological University is a education organization based out in Singapore, Singapore. It is known for research contribution in the topics: Computer science & Catalysis. The organization has 48003 authors who have published 112815 publications receiving 3294199 citations. The organization is also known as: NTU & Universiti Teknologi Nanyang.

Chaperone-mediated autophagy: roles in disease and aging

Abstract: This review focuses on chaperone-mediated autophagy (CMA), one of the proteolytic systems that contributes to degradation of intracellular proteins in lysosomes. CMA substrate proteins are selectively targeted to lysosomes and translocated into the lysosomal lumen through the coordinated action of chaperones located at both sides of the membrane and a dedicated protein translocation complex. The selectivity of CMA permits timed degradation of specific proteins with regulatory purposes supporting a modulatory role for CMA in enzymatic metabolic processes and subsets of the cellular transcriptional program. In addition, CMA contributes to cellular quality control through the removal of damaged or malfunctioning proteins. Here, we describe recent advances in the understanding of the molecular dynamics, regulation and physiology of CMA, and discuss the evidence in support of the contribution of CMA dysfunction to severe human disorders such as neurodegeneration and cancer.

Recent Development of Advanced Materials with Special Wettability for Selective Oil/Water Separation.

Abstract: The increasing number of oil spill accidents have a catastrophic impact on our aquatic environment. Recently, special wettable materials used for the oil/water separation have received significant research attention. Due to their opposing affinities towards water and oil, i.e., hydrophobic and oleophilic, or hydrophilic and oleophobic, such materials can be used to remove only one phase from the oil/water mixture, and simultaneously repel the other phase, thus achieving selective oil/water separation. Moreover, the synergistic effect between the surface chemistry and surface architecture can further promote the superwetting behavior, resulting in the improved separation efficiency. Here, recently developed materials with special wettability for selective oil/water separation are summarized and discussed. These materials can be categorized based on their oil/water separating mechanisms, i.e., filtration and absorption. In each section, representative studies will be highlighted, with emphasis on the materials wetting properties and innovative aspects. Finally, challenges and future research directions in this emerging and promising research field will be briefly described.

Optimal Workload Allocation in Fog-Cloud Computing Toward Balanced Delay and Power Consumption

Abstract: Mobile users typically have high demand on localized and location-based information services. To always retrieve the localized data from the remote cloud, however, tends to be inefficient, which motivates fog computing. The fog computing, also known as edge computing, extends cloud computing by deploying localized computing facilities at the premise of users, which prestores cloud data and distributes to mobile users with fast-rate local connections. As such, fog computing introduces an intermediate fog layer between mobile users and cloud, and complements cloud computing toward low-latency high-rate services to mobile users. In this fundamental framework, it is important to study the interplay and cooperation between the edge (fog) and the core (cloud). In this paper, the tradeoff between power consumption and transmission delay in the fog-cloud computing system is investigated. We formulate a workload allocation problem which suggests the optimal workload allocations between fog and cloud toward the minimal power consumption with the constrained service delay. The problem is then tackled using an approximate approach by decomposing the primal problem into three subproblems of corresponding subsystems, which can be, respectively, solved. Finally, based on simulations and numerical results, we show that by sacrificing modest computation resources to save communication bandwidth and reduce transmission latency, fog computing can significantly improve the performance of cloud computing.

A Review of Phosphide-Based Materials for Electrocatalytic Hydrogen Evolution

Abstract: Hydrogen evolution by means of electrocatalytic water-splitting is pivotal for efficient and economical production of hydrogen, which relies on the development of inexpensive, highly active catalysts. In addition to sulfides, the search for non-noble metal catalysts has been mainly directed at phosphides due to the superb activity of phosphides for hydrogen evolution reaction (HER) and their low-cost considering the abundance of the non-noble constituents of phosphides. Here, recent research focusing on phosphides is summarized based on their synthetic methodology. A comparative study of the catalytic activity of different phosphides towards HER is then conducted. The catalytic activity is evaluated by overpotentials at fixed current density, Tafel slope, turnover frequency, and the Gibbs free energy of hydrogen adsorption. Based on the methods discussed, perspectives for the various methods of phosphides synthesis are given, and the origins of the high activity and the role of phosphorus on the improved activity towards HER are discussed.