National University of La Plata

About: National University of La Plata is a education organization based out in La Plata, Argentina. It is known for research contribution in the topics: Population & Stars. The organization has 12993 authors who have published 30013 publications receiving 495118 citations. The organization is also known as: UNLP & Universidad Nacional de La Plata.

The head and neck cancer cell oncogenome: A platform for the development of precision molecular therapies

Abstract: // Daniel Martin 1 , Martin C. Abba 2 , Alfredo A. Molinolo 1 , Lynn Vitale-Cross 1 , Zhiyong Wang 1 , Moraima Zaida 1 , Naomi C. Delic 4, 5 , Yardena Samuels 3 , J. Guy Lyons 4, 5 , J. Silvio Gutkind 1 1 Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, USA 2 CINIBA, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, La Plata, Argentina 3 Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel 4 Dermatology, University of Sydney, Camperdown, Australia 5 Cancer Services, Royal Prince Alfred Hospital, Camperdown, Australia Correspondence to: Silvio Gutkind, e-mail: sg39v@nih.gov Keywords: HNSCC, Sequencing, Exome, RNAseq, Cancer Received: July 11, 2014 Accepted: August 28, 2014 Published: November 04, 2014 ABSTRACT The recent elucidation of the genomic landscape of head and neck squamous cell carcinoma (HNSCC) has provided a unique opportunity to develop selective cancer treatment options. These efforts will require the establishment of relevant HNSCC models for preclinical testing. Here, we performed full exome and transcriptome sequencing of a large panel of HNSCC-derived cells from different anatomical locations and human papillomavirus (HPV) infection status. These cells exhibit typical mutations in TP53 , FAT1 , CDK2NA , CASP8 , and NOTCH1 , and copy number variations (CNVs) and mutations in PIK3CA , HRAS , and PTEN that reflect the widespread activation of the PI3K-mTOR pathway. SMAD4 alterations were observed that may explain the decreased tumor suppressive effect of TGF-β in HNSCC. Surprisingly, we identified HPV + HNSCC cells harboring TP53 mutations, and documented aberrant TP53 expression in a subset of HPV + HNSCC cases. This analysis also revealed that most HNSCC cells harbor multiple mutations and CNVs in epigenetic modifiers (e.g., EP300, CREBP, MLL1, MLL2, MLL3, KDM6A, and KDM6B) that may contribute to HNSCC initiation and progression. These genetically-defined experimental HNSCC cellular systems, together with the identification of novel actionable molecular targets, may now facilitate the pre-clinical evaluation of emerging therapeutic agents in tumors exhibiting each precise genomic alteration.

Effects of acidosis on phosphorylation of phospholamban and troponin I in rat cardiac muscle

Abstract: Acidosis inhibits Ca2+ transport by the sarcoplasmic reticulum of cardiac muscle and decreases the Ca2+ sensitivity of the contractile proteins, although the mechanisms underlying these changes are...

Nonlinear control of a permanent magnet synchronous motor with disturbance torque estimation

Abstract: This paper introduces a sensorless nonlinear control scheme for controlling the speed of a permanent magnet synchronous motor (PMSM) driving an unknown load torque. The states of the motor and disturbance torque are estimated via an extended nonlinear observer avoiding the use of mechanical sensors. The control strategy is an exact feedback linearization law, with trajectory tracking evaluated on estimated values of the PMSM states and the disturbance torque. The system performance is evaluated by simulations.