Institution
National University of La Plata
Education•La Plata, Argentina•
About: National University of La Plata is a education organization based out in La Plata, Argentina. It is known for research contribution in the topics: Population & Stars. The organization has 12993 authors who have published 30013 publications receiving 495118 citations. The organization is also known as: UNLP & Universidad Nacional de La Plata.
Papers published on a yearly basis
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Columbia University1, Queen's University2, National University of La Plata3, French Institute of Health and Medical Research4, Medical Research Council5, University of British Columbia6, Israel Ministry of Health7, International Agency for Research on Cancer8, University of Melbourne9, National University of Singapore10, University of California, San Francisco11, University of Toronto12, University of Southern California13, Fred Hutchinson Cancer Research Center14, University of Utah15, Harvard University16, National and Kapodistrian University of Athens17, Stanford University18
TL;DR: The analysis suggests that, among these case-control studies, there is no energy-independent association between dietary fat intake and risk of colorectal cancer, and suggests that simple substitution of fat by other sources of calories is unlikely to reduce meaningfully the risk of colon cancer.
Abstract: The objective of this study was to examine the effects of the intakeof dietary fat upon colorectal cancer risk in a combined analysis of datafrom 13 case-control studies previously conducted in populations withdiffering colorectal cancer rates and dietary practices. Original datarecords for 5,287 cases of colorectal cancer and 10,470 controls werecombined. Logistic regression analysis was used to estimate odds ratios (OR)for intakes of total energy, total fat and its components, and cholesterol.Positive associations with energy intake were observed for 11 of the 13studies. However, there was little, if any, evidence of anyenergy-independent effect of either total fat with ORs of 1.00, 0.95, 1.01,1.02, and 0.92 for quintiles of residuals of total fat intake (P trend =0.67) or for saturated fat with ORs of 1.00, 1.08, 1.06, 1.21, and 1.06 (Ptrend = 0.39). The analysis suggests that, among these case-control studies,there is no energy-independent association between dietary fat intake andrisk of colorectal cancer. It also suggests that simple substitution of fatby other sources of calories is unlikely to reduce meaningfully the risk ofcolorectal cancer.
190 citations
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TL;DR: In this paper, the success of pectin as an eco-friendly corrosion inhibitor for mild steel in HCl solution is discussed considering thermodynamics of adsorption and kinetics of the electrochemical reactions.
190 citations
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TL;DR: Glyphosate and AMPA should be considered "pseudo-persistent" pollutants and a revisions of management procedures, monitoring programs, and ecological risk for soil and sediments should be also recommended.
190 citations
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TL;DR: In this paper, a single-flavor limit to the diffuse flux of ultrahigh energy neutrinos with an E-2 spectrum in the energy range 1.0×1017eV-2.
Abstract: Neutrinos in the cosmic ray flux with energies near 1 EeV and above are detectable with the Surface Detector array (SD) of the Pierre Auger Observatory. We report here on searches through Auger data from 1 January 2004 until 20 June 2013. No neutrino candidates were found, yielding a limit to the diffuse flux of ultrahigh energy neutrinos that challenges the Waxman-Bahcall bound predictions. Neutrino identification is attempted using the broad time structure of the signals expected in the SD stations, and is efficiently done for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for "Earth-skimming" neutrino interactions in the case of tau neutrinos. In this paper the searches for downward-going neutrinos in the zenith angle bins 60°-75°and 75°-90°as well as for upward-going neutrinos, are combined to give a single limit. The 90% C.L. single-flavor limit to the diffuse flux of ultrahigh energy neutrinos with an E-2 spectrum in the energy range 1.0×1017eV-2.5×1019eV is Eν2dNν/dEν<6.4×10-9GeVcm-2s-1sr-1.
189 citations
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TL;DR: It is found that metformin causes an osteogenic effect both in vivo and in vitro, possibly mediated by Runx2/Cbfa1 and AMPK activation, suggesting a possible action of met formin in a shift toward the osteoblastic differentiation of BMPCs.
Abstract: Diabetes mellitus is associated with bone loss. Patients with type 2 diabetes are frequently treated with oral antidiabetic drugs such as sulfonylureas, biguanides, and thiazolidinediones. Rosiglitazone treatment has been shown to increase adipogenesis in bone marrow and to induce bone loss. In this study we evaluated the effect of in vivo and in vitro treatment with metformin on bone marrow progenitor cells (BMPCs), as well as the involvement of AMPK pathway in its effects. The in vitro effect of coincubation with metformin and rosiglitazone on the adipogenic differentiation of BMPCs also was studied. In addition, we evaluated the effect of in vivo metformin treatment on bone regeneration in a model of parietal lesions in nondiabetic and streptozotocin-induced diabetic rats. We found that metformin administration both in vivo and in vitro caused an increase in alkaline phosphatase activity, type I collagen synthesis, osteocalcin expression, and extracellular calcium deposition of BMPCs. Moreover, metformin significantly activated AMPK in undifferentiated BMPCs. In vivo, metformin administration enhanced the expression of osteoblast-specific transcription factor Runx2/Cbfa1 and activation of AMPK in a time-dependent manner. Metformin treatment also stimulated bone lesion regeneration in control and diabetic rats. In vitro, metformin partially inhibited the adipogenic actions of rosiglitazone on BMPCs. In conclusion, our results indicate that metformin causes an osteogenic effect both in vivo and in vitro, possibly mediated by Runx2/Cbfa1 and AMPK activation, suggesting a possible action of metformin in a shift toward the osteoblastic differentiation of BMPCs.
189 citations
Authors
Showing all 13198 results
Name | H-index | Papers | Citations |
---|---|---|---|
David Cameron | 154 | 1586 | 126067 |
Subir Sarkar | 149 | 1542 | 144614 |
Mayda Velasco | 137 | 1309 | 87579 |
Diego F. Torres | 137 | 948 | 72180 |
Heidi Sandaker | 128 | 999 | 76517 |
Vincent Garonne | 128 | 921 | 76980 |
Farid Ould-Saada | 128 | 931 | 76394 |
Ole Røhne | 128 | 1038 | 75752 |
Peter Hansen | 128 | 1271 | 86210 |
Maria-Teresa Dova | 127 | 778 | 73558 |
Vladimir Sulin | 127 | 884 | 75329 |
Andrei Snesarev | 127 | 875 | 74907 |
James Catmore | 127 | 892 | 75086 |
Ruslan Mashinistov | 126 | 860 | 73897 |
Fernando Monticelli | 126 | 843 | 73385 |