Institution
Stockholm County Council
Government•Stockholm, Sweden•
About: Stockholm County Council is a government organization based out in Stockholm, Sweden. It is known for research contribution in the topics: Population & Poison control. The organization has 1410 authors who have published 2429 publications receiving 78936 citations.
Topics: Population, Poison control, Health care, Autism, Cohort study
Papers published on a yearly basis
Papers
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Aarhus University1, Harvard University2, Karolinska Institutet3, Stockholm County Council4, Broad Institute5, Statens Serum Institut6, University of California, Los Angeles7, Charité8, Oslo University Hospital9, University of Toronto10, VU University Amsterdam11, University of Barcelona12, Radboud University Nijmegen13, Yale University14, Children's Hospital of Philadelphia15, University of Pennsylvania16, King's College London17, Cardiff University18, University of Würzburg19, University of Queensland20, Goethe University Frankfurt21, Universidade Federal do Rio Grande do Sul22, Icahn School of Medicine at Mount Sinai23, University of North Carolina at Chapel Hill24, Emory University25, University of Copenhagen26, State University of New York Upstate Medical University27
TL;DR: The hypothesis that clinical diagnosis of ADHD is an extreme expression of one or more continuous heritable traits is supported, supported by additional analyses of a self-reported ADHD sample and a study of quantitative measures of ADHD symptoms in the population.
Abstract: Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of school-age children and 25% of adults Common genetic variants contribute substantially to ADHD susceptibility, but no individual variants have been robustly associated with ADHD We report a genome-wide association meta-analysis of 20,183 ADHD cases and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, revealing new and important information on the underlying biology of ADHD Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes, as well as around brain-expressed regulatory marks These findings, based on clinical interviews and/or medical records are supported by additional analyses of a self-reported ADHD sample and a study of quantitative measures of ADHD symptoms in the population Meta-analyzing these data with our primary scan yielded a total of 16 genome-wide significant loci The results support the hypothesis that clinical diagnosis of ADHD is an extreme expression of one or more continuous heritable traits
230 citations
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University of Helsinki1, University College London2, Turku University Hospital3, Finnish Institute of Occupational Health4, Karolinska Institutet5, Stockholm County Council6, Stockholm University7, Jönköping University8, Paris Descartes University9, University of London10, Mid Sweden University11, University of Copenhagen12, Uppsala University13, Loughborough University14, University of Bristol15
TL;DR: The number of years free from major non-communicable diseases in adults who are overweight and obese, compared with those who are normal weight was estimated, with increasing loss of disease-free years as obesity becomes more severe.
Abstract: Background Obesity increases the risk of several chronic diseases, but the extent to which the obesity-related loss of disease-free years varies by lifestyle category and across socioeconomic group
228 citations
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TL;DR: A new questionnaire tool for surveys on work‐related skin disease and exposures to environmental factors and a comprehensive manual for researchers on planning and conducting a questionnaire survey on hand eczema and relevant exposures are included.
Abstract: Occupational skin diseases are among the most frequent work-related diseases in industrialized countries Good occupational skin disease statistics exist in few countries Questionnaire studies are needed to get more data on the epidemiology of occupational skin diseases The Nordic Occupational Skin Questionnaire Group has developed a new questionnaire tool - Nordic Occupational Skin Questionnaire (NOSQ-2002) - for surveys on work-related skin disease and exposures to environmental factors The 2 NOSQ-2002 questionnaires have been compiled by using existing questionnaires and experience NOSQ-2002/SHORT is a ready-to-use 4-page questionnaire for screening and monitoring occupational skin diseases, eg in a population or workplace All the questions in the short questionnaire (NOSQ-2002/SHORT) are included in the long version, NOSQ-2002/LONG, which contains a pool of questions to be chosen according to research needs and tailored to specific populations The NOSQ-2002 report includes, in addition to the questionnaires, a comprehensive manual for researchers on planning and conducting a questionnaire survey on hand eczema and relevant exposures NOSQ-2002 questionnaires have been compiled in English and translated into Danish, Swedish, Finnish and Icelandic The use of NOSQ-2002 will benefit research on occupational skin diseases by providing more standardized data, which can be compared between studies and countries
225 citations
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TL;DR: In conclusion, microvascular complications of diabetes were retarded by intensified conventional insulin treatment, however, such treatment increased the frequency of serious hypoglycaemia, and led to an increase in body weight.
Abstract: Ninety-six patients with insulin-dependent diabetes mellitus (IDDM) and non-proliferative retinopathy were randomized to intensified conventional treatment (ICT) (n = 44) or regular treatment (RT) (n = 52), and followed up for 5 years. HbA1c decreased from 9.5 +/- 0.2% (mean value +/- SEM) to 7.2 +/- 0.1% in the ICT group, and from 9.4 +/- 0.2% to 8.7 +/- 0.1% in the RT group (difference between the groups, P less than 0.001). Retinopathy increased in both groups (P less than 0.001), but after 5 years it was worse in the RT group (P less than 0.05). The urinary albumin excretion rate was higher in the RT group than in the ICT group after 5 years (239.9 +/- 129.7 micrograms min-1 vs. 46.0 +/- 26.1 micrograms min-1, P less than 0.05). Eight RT patients developed manifest nephropathy, compared with none in the ICT group (P less than 0.01). After 5 years the conduction velocities of the sural (P less than 0.05), peroneal (P less than 0.01) and tibial (P less than 0.001) nerves were lower in the RT group. The respiratory sinus arrhythmia was 12.1 +/- 1.2 beats min-1 in the RT group and 16.7 +/- 1.4 beats min-1 in the ICT group at the end of the study (P less than 0.01). The increases in retinopathy (P less than 0.01), nephropathy (P less than 0.01) and neuropathy (P less than 0.001) were all related to the mean HbA1c value during the study. Smoking habits only influenced the progression of retinopathy (P less than 0.05). Serious hypoglycaemia occurred in 34 ICT patients and 29 RT patients (242 and 98 episodes, respectively) (P less than 0.05). Whereas weight was stable in the RT group, the body mass index increased by 5.8% in the ICT group (P less than 0.01). In conclusion, microvascular complications of diabetes were retarded by intensified conventional insulin treatment. However, such treatment increased the frequency of serious hypoglycaemia, and led to an increase in body weight.
223 citations
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TL;DR: The measurement of PM2.5 absorbance was highly correlated with EC measurements and suggests that absorbance can be used as a simple, inexpensive and non-destructive method to estimate motorized traffic-related particulate air pollution.
Abstract: Here we compare PM(2.5) (particles with aerodynamic diameter less than 2.5 microm) mass and filter absorbance measurements with elemental carbon (EC) concentrations measured in parallel at the same site as well as collocated PM(2.5) and PM(10) (particles with aerodynamic diameter less than 10 microm) mass and absorbance measurements. The data were collected within the Traffic-Related Air Pollution on Childhood Asthma (TRAPCA) study in Germany, The Netherlands and Sweden. The study was designed to assess the health impact of spatial contrasts in long-term average concentrations. The measurement sites were distributed between background and traffic locations. Annual EC and PM(2.5) absorbance measurements were at traffic sites on average 43-84% and 26-76% higher, respectively, compared to urban background sites. The contrast for PM(2.5) mass measurements was lower (8-35%). The smaller contrast observed for PM(2.5) mass in comparison with PM(2.5) absorbance and EC documents that PM(2.5) mass underestimates exposure contrasts related to motorized traffic emissions. The correlation between PM(10) and PM(2.5) was high, documenting that most of the spatial variation of PM(10) was because of PM(2.5). The measurement of PM(2.5) absorbance was highly correlated with EC measurements and suggests that absorbance can be used as a simple, inexpensive and non-destructive method to estimate motorized traffic-related particulate air pollution. The EC/absorbance relation differed between countries and site type (background/traffic), supporting the need for site-specific calibrations of the simple absorbance method. While the ratio between PM(2.5) and PM(10) mass ranged from 0.54 to 0.68, the ratio of PM(2.5) absorbance and PM(10) absorbance was 0.96-0.97, indicating that PM(2.5) absorbance captures nearly all of the particle absorbance.
222 citations
Authors
Showing all 1415 results
Name | H-index | Papers | Citations |
---|---|---|---|
Lars Klareskog | 131 | 697 | 63281 |
Christopher A. Walsh | 123 | 455 | 55874 |
Jan K. Buitelaar | 123 | 1004 | 61880 |
Gerhard Andersson | 118 | 902 | 49159 |
Lars Alfredsson | 112 | 607 | 51151 |
Sarah E. Medland | 106 | 462 | 46888 |
Tomas Olsson | 105 | 677 | 39905 |
René E. M. Toes | 101 | 454 | 39812 |
Göran Pershagen | 98 | 432 | 33214 |
Juha Kere | 97 | 642 | 38403 |
Agneta Nordberg | 93 | 513 | 39763 |
Lars Farde | 90 | 446 | 28122 |
G. David Batty | 88 | 451 | 23826 |
Christer Halldin | 87 | 713 | 32079 |
Anders Ahlbom | 87 | 359 | 27369 |