Institution
Stockholm County Council
Government•Stockholm, Sweden•
About: Stockholm County Council is a government organization based out in Stockholm, Sweden. It is known for research contribution in the topics: Population & Poison control. The organization has 1410 authors who have published 2429 publications receiving 78936 citations.
Topics: Population, Poison control, Health care, Autism, Cohort study
Papers published on a yearly basis
Papers
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TL;DR: The presence of comorbidities should be considered when counseling patients with newly diagnosed epilepsy concerning risk for injuries/accidents, as the risk is highest during the first 2 years following seizure onset.
Abstract: Objective To study the risk for injuries/accidents in people with newly diagnosed epileptic seizures in relation to comorbidities. Methods Between September 1, 2001, and August 31, 2008, individuals in northern Stockholm with incident unprovoked seizures (epilepsy; n = 2,130) were included in a registry. For every epilepsy patient, 8 individuals matched for sex and inclusion year (n = 16,992) were randomly selected as references from the population of the catchment area. Occurrence of injuries/accidents was monitored through the national patient and cause of death registers until December 31, 2013. These registers also provided information on comorbidities (e.g., brain tumor, stroke, psychiatric disease, diabetes mellitus). Results Injury/accident was demonstrated in 1,033 epilepsy cases and 6,202 references (hazard ratio [HR] 1.71, 95% confidence interval 1.60–1.83). The excess risk was seen mainly during the first 2 years after diagnosis. Sex and educational status had no significant effect on HR. The risk was normal in children but increased in adults. Highest HR was seen for drowning, poisoning, adverse effect of medication, and severe traumatic brain injury. Compared to references without comorbidities, HR was 1.17 (1.07–1.28) in epilepsy without comorbidities, 4.52 (4.18–4.88) in references with comorbidities, and 7.15 (6.49–7.87) in epilepsy with comorbidities. Conclusion Presence of comorbidities should be considered when counseling patients with newly diagnosed epilepsy concerning risk for injuries/accidents. Early information is important, as the risk is highest during the first 2 years following seizure onset.
39 citations
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TL;DR: Cobalt allergy is frequent, but knowledge about exposure is limited and the patch test concentration and relevance of positive reactions are sometimes questioned.
Abstract: SummaryBackground
Cobalt allergy is frequent, but knowledge about exposure is limited. The patch test concentration and relevance of positive reactions are sometimes questioned.
Objectives
To assess the suitability of cobalt 1% versus 0.5% for patch testing, and to analyse the co-occurrence of allergy to cobalt, chromium, and nickel.
Materials and methods
Consecutive dermatitis patients (n = 656) were patch tested with cobalt chloride 0.5% and 1%, potassium dichromate 0.5%, and nickel sulfate 5%, all in petrolatum. Reactions were assessed on day (D)3, and on D6 or D7, and the reactivity and development of reactions were analysed.
Results
Allergy to any metal was shown in 31% of patients, allergy to cobalt in 14%, allergy to chromium in 7%, and allergy to nickel in 20%. A significant proportion (37%) of cobalt allergy cases were missed by cobalt 0.5% versus 1%, whereas the reactivity profiles were similar. Cobalt allergy was solitary, without concomitant allergy to chromium or nickel, in 50% of patients.
Conclusions
Cobalt chloride 1% pet. is more suitable for patch testing than 0.5%. Solitary cobalt allergy is as frequent as concomitant allergy to cobalt and nickel or chromium. Sources of skin exposure to metals need to be identified for prevention of contact allergy. This is, owing to large knowledge gaps, particularly demanding for cobalt.
39 citations
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TL;DR: Since MIRU-VNTR is faster and less labour-intensive it is the method of choice for routine genotyping and in most cases it will be sufficient for epidemiological purposes but true clustering might still be considered if there are epidemiological links and the MIRu-VnTR results differ in only one of its 24 loci.
Abstract: Our aim was to analyze the difference between methods for genotyping of Mycobacterium tuberculosis complex isolates. We collected genotyping results from Restriction Fragment Length Polymorphism (RFLP) and Mycobacterial Interspersed Repetitive Units - Variable Numbers of Tandem Repeat (MIRU-VNTR) in a geographically limited area (Stockholm) during a period of three years. The number and proportion of isolates belonging to clusters was reduced by 45 and 35% respectively when combining the two methods compared with using RFLP or MIRU-VNTR only. The mean size of the clusters was smaller when combining methods and smaller with RFLP compared to MIRU-VNTR. In clusters with confirmed epidemiological links RFLP coincided slightly better than MIRU-VNTR but where there was a difference, the variation in MIRU-VNTR pattern was only in a single locus. In isolates with few IS6110 bands in RFLP, MIRU-VNTR differentiated the isolates more, dividing the RFLP clusters. Since MIRU-VNTR is faster and less labour-intensive it is the method of choice for routine genotyping. In most cases it will be sufficient for epidemiological purposes but true clustering might still be considered if there are epidemiological links and the MIRU-VNTR results differ in only one of its 24 loci.
38 citations
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Charité1, University of Würzburg2, Imperial College London3, University of Tartu4, Max Planck Society5, University of Gothenburg6, Karolinska University Hospital7, Karolinska Institutet8, University Hospital Bonn9, Harvard University10, University of Bonn11, University of Duisburg-Essen12, University of Marburg13, University of Basel14, Goethe University Frankfurt15, University of Mannheim16, University of Münster17, Humboldt University of Berlin18, University of Cologne19, University of Greifswald20, Dresden University of Technology21, Heidelberg University22, University of Freiburg23, University of Helsinki24, Stockholm County Council25, Public Health Research Institute26, VU University Amsterdam27, deCODE genetics28, University of Liverpool29, Mental Health Services30, University of Copenhagen31, Aarhus University32, Lundbeck33, Statens Serum Institut34, University of North Carolina at Chapel Hill35, Aarhus University Hospital36, Emory University37, Broad Institute38
TL;DR: The present integrative analysis represents a major step towards the elucidation of the genetic susceptibility to PD.
Abstract: Panic disorder (PD) has a lifetime prevalence of 2-4% and heritability estimates of 40%. The contributory genetic variants remain largely unknown, with few and inconsistent loci having been reported. The present report describes the largest genome-wide association study (GWAS) of PD to date comprising genome-wide genotype data of 2248 clinically well-characterized PD patients and 7992 ethnically matched controls. The samples originated from four European countries (Denmark, Estonia, Germany, and Sweden). Standard GWAS quality control procedures were conducted on each individual dataset, and imputation was performed using the 1000 Genomes Project reference panel. A meta-analysis was then performed using the Ricopili pipeline. No genome-wide significant locus was identified. Leave-one-out analyses generated highly significant polygenic risk scores (PRS) (explained variance of up to 2.6%). Linkage disequilibrium (LD) score regression analysis of the GWAS data showed that the estimated heritability for PD was 28.0-34.2%. After correction for multiple testing, a significant genetic correlation was found between PD and major depressive disorder, depressive symptoms, and neuroticism. A total of 255 single-nucleotide polymorphisms (SNPs) with p < 1 × 10-4 were followed up in an independent sample of 2408 PD patients and 228,470 controls from Denmark, Iceland and the Netherlands. In the combined analysis, SNP rs144783209 showed the strongest association with PD (pcomb = 3.10 × 10-7). Sign tests revealed a significant enrichment of SNPs with a discovery p-value of <0.0001 in the combined follow up cohort (p = 0.048). The present integrative analysis represents a major step towards the elucidation of the genetic susceptibility to PD.
38 citations
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TL;DR: This work states that contact allergy prevalence rates change over time as a result of variations in allergen exposure.
Abstract: Background. Contact allergy prevalence rates change over time as a result of variations in allergen exposure. Data from patch test clinics are often used as markers for allergy trends.Objectives. T ...
38 citations
Authors
Showing all 1415 results
Name | H-index | Papers | Citations |
---|---|---|---|
Lars Klareskog | 131 | 697 | 63281 |
Christopher A. Walsh | 123 | 455 | 55874 |
Jan K. Buitelaar | 123 | 1004 | 61880 |
Gerhard Andersson | 118 | 902 | 49159 |
Lars Alfredsson | 112 | 607 | 51151 |
Sarah E. Medland | 106 | 462 | 46888 |
Tomas Olsson | 105 | 677 | 39905 |
René E. M. Toes | 101 | 454 | 39812 |
Göran Pershagen | 98 | 432 | 33214 |
Juha Kere | 97 | 642 | 38403 |
Agneta Nordberg | 93 | 513 | 39763 |
Lars Farde | 90 | 446 | 28122 |
G. David Batty | 88 | 451 | 23826 |
Christer Halldin | 87 | 713 | 32079 |
Anders Ahlbom | 87 | 359 | 27369 |