Institution
Tallinn University of Technology
Education•Tallinn, Estonia•
About: Tallinn University of Technology is a education organization based out in Tallinn, Estonia. It is known for research contribution in the topics: European union & Computer science. The organization has 3688 authors who have published 10313 publications receiving 145058 citations. The organization is also known as: Tallinn Technical University & Tallinna Tehnikaülikool.
Topics: European union, Computer science, Oil shale, Nonlinear system, Thin film
Papers published on a yearly basis
Papers
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TL;DR: A set of 12 compounds, predicted to interact with the active center of nsP2 protease, was designed using target-based modeling and the majority of these compounds were shown to inhibit the ability of ns P2 to process recombinant protein and synthetic peptide substrates.
Abstract: Chikungunya virus (CHIKV; genus Alphavirus) is the causative agent of chikungunya fever. CHIKV replication can be inhibited by some broad-spectrum antiviral compounds; in contrast, there is very little information about compounds specifically inhibiting the enzymatic activities of CHIKV replication proteins. These proteins are translated in the form of a nonstructural (ns) P1234 polyprotein precursor from the CHIKV positive-strand RNA genome. Active forms of replicase enzymes are generated using the autoproteolytic activity of nsP2. The available three-dimensional (3D) structure of nsP2 protease has made it a target for in silico drug design; however, there is thus far little evidence that the designed compounds indeed inhibit the protease activity of nsP2 and/or suppress CHIKV replication. In this study, a set of 12 compounds, predicted to interact with the active center of nsP2 protease, was designed using target-based modeling. The majority of these compounds were shown to inhibit the ability of nsP2 to process recombinant protein and synthetic peptide substrates. Furthermore, all compounds found to be active in these cell-free assays also suppressed CHIKV replication in cell culture, the 50% effective concentration (EC50) of the most potent inhibitor being ∼1.5 μM. Analysis of stereoisomers of one compound revealed that inhibition of both the nsP2 protease activity and CHIKV replication depended on the conformation of the inhibitor. Combining the data obtained from different assays also indicates that some of the analyzed compounds may suppress CHIKV replication using more than one mechanism.
40 citations
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TL;DR: The findings of this study suggest that FOXO3a levels are increased in HD cells as a result of overactive positive feedback loop.
40 citations
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TL;DR: In this paper, the fluidized bed gasification of untreated and pre-treated olive residue and pre treated olive residue mixed with reed, pine pellets and Douglas fir wood chips is studied.
40 citations
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28 Oct 2019
TL;DR: In this paper, the authors provide a comprehensive information about extracting valuable metals from e-waste and identify some of the most critical challenges for ewaste environmentally sound management practices, and opinions on possible solutions for exiting challenges, and emphasis on the importance of advanced recycling technologies that can be utilized, in order to minimize the environmental impact causes due to improper recycling of e waste.
Abstract: The rapid e-waste volume is generating globally. At the same time, different recycling technologies, mainly the mechanical and chemical methods well studied, while the biological method is the most promising approach. Therefore, this article provides a comprehensive information about extracting valuable metals from e-waste. In addition, this article outlines the process and key opportunity for extraction of metals, identifies some of the most critical challenges for e-waste environmentally sound management practices, and opinions on possible solutions for exiting challenges, and emphasis on importance of advanced recycling technologies that can be utilized, in order to minimize the environmental impact causes due to improper recycling of e-waste.
40 citations
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TL;DR: A holistic approach by means of the analytic hierarchy process (AHP) that uses numerical representation to rank the preferences of each participating alternatives for evaluation of the advanced biological technologies in CW treatment is developed.
40 citations
Authors
Showing all 3757 results
Name | H-index | Papers | Citations |
---|---|---|---|
James Chapman | 82 | 483 | 36468 |
Alexandre Alexakis | 67 | 540 | 17247 |
Bernard Waeber | 56 | 370 | 35335 |
Peter A. Andrekson | 54 | 573 | 12042 |
Charles S. Peirce | 51 | 167 | 11998 |
Lars M. Blank | 49 | 301 | 8011 |
Fushuan Wen | 49 | 465 | 9189 |
Mati Karelson | 48 | 207 | 10210 |
Ago Samoson | 46 | 119 | 8807 |
Zebo Peng | 45 | 359 | 7312 |
Petru Eles | 44 | 300 | 6749 |
Vijai Kumar Gupta | 43 | 301 | 6901 |
Eero Vasar | 43 | 263 | 6930 |
Rik Ossenkoppele | 42 | 192 | 6839 |
Tõnis Timmusk | 41 | 105 | 11056 |