Institution
Trinity College, Dublin
Education•Dublin, Dublin, Ireland•
About: Trinity College, Dublin is a education organization based out in Dublin, Dublin, Ireland. It is known for research contribution in the topics: Population & Context (language use). The organization has 20576 authors who have published 48296 publications receiving 1780313 citations.
Topics: Population, Context (language use), Irish, Health care, Mental health
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this article, the light-induced reactions of methylene blue and related phenothiazinium dyes with biological substrates are described and the properties of the excited states of the dyes, their reactions with nucleic acids and their photosensitised chemical modifications of nucleic acid bases are examined.
Abstract: The light-induced reactions of methylene blue and related phenothiazinium dyes with biological substrates are described. The properties of the excited states of the dyes, their reactions with nucleic acids and their photosensitised chemical modifications of nucleic acid bases are examined. Reports on phenothiazinium dye-induced damage to proteins, lipids, biological membranes, organelles, viruses, bacteria, mammalian cells and carcinomas are reviewed.
308 citations
•
01 Jan 1999TL;DR: This work focuses on the development of modern languages in the context of the L2 MENTAL LEXICON and its role in the criminal justice system.
Abstract: Unlike many recent books on L2 vocabulary and processing, this volume does not set out to offer a complex perspective of the L2 lexicon, but rather represents a sustained attempt to come to grips with some very basic questions clustered around the relationship between the L2 mental lexicon and the L1 mental lexicon It provides a substantial review of L1 and L2 lexical research issues such as similarities and differences between the conditions of L1 and L2 acquisition, the respective roles of form and meaning in L1 and L2 processing, and the degree of separation/integration between L1 and the L2 lexical operations New research into the L2 lexicon from the Trinity College Dublin Modern Languages Project is considered in the latter part of the volume
307 citations
••
TL;DR: A role for the amygdala in processing emotional stimuli that extends beyond negative and fearful stimuli is demonstrated, and arousal level is clearly demonstrated to modulate the amygdala response.
Abstract: Human lesion and functional imaging data suggest a central role for the amygdala in the processing of negative stimuli. To determine whether the amygdala's role in affective processing extends beyond negative stimuli, subjects viewed pictures that varied in emotional content (positive vs negative valence) and arousal level (high vs low) while undergoing functional magnetic resonance imaging. Amygdala activation, relative to a low arousal and neutral valence picture baseline, was significantly increased for both positively and negatively valenced stimuli and did not differ for the two valences. There were no laterality effects. Whereas arousal level appeared to modulate the amygdala response for negative stimuli, all positively valenced pictures (both high and low in arousal) produced significant amygdala responses. These results clearly demonstrate a role for the amygdala in processing emotional stimuli that extends beyond negative and fearful stimuli.
307 citations
••
St James's University Hospital1, Radboud University Nijmegen Medical Centre2, University of Duisburg-Essen3, University of Cambridge4, University of Ulm5, Royal Melbourne Hospital6, Trinity College, Dublin7, Cleveland Clinic8, Saarland University9, Duke University10, French Institute of Health and Medical Research11, Johns Hopkins University School of Medicine12
TL;DR: Eculizumab has a substantial impact on the symptoms and complications of PNH and results a significant improvement in patient survival, with no evidence of cumulative toxicity and a decreasing occurrence of adverse events over time.
Abstract: Paroxysmal nocturnal haemoglobinuria (PNH) is characterized by chronic, uncontrolled complement activation resulting in elevated intravascular haemolysis and morbidities, including fatigue, dyspnoea, abdominal pain, pulmonary hypertension, thrombotic events (TEs) and chronic kidney disease (CKD). The long-term safety and efficacy of eculizumab, a humanized monoclonal antibody that inhibits terminal complement activation, was investigated in 195 patients over 66 months. Four patient deaths were reported, all unrelated to treatment, resulting in a 3-year survival estimate of 97·6%. All patients showed a reduction in lactate dehydrogenase levels, which was sustained over the course of treatment (median reduction of 86·9% at 36 months), reflecting inhibition of chronic haemolysis. TEs decreased by 81·8%, with 96·4% of patients remaining free of TEs. Patients also showed a time-dependent improvement in renal function: 93·1% of patients exhibited improvement or stabilization in CKD score at 36 months. Transfusion independence increased by 90·0% from baseline, with the number of red blood cell units transfused decreasing by 54·7%. Eculizumab was well tolerated, with no evidence of cumulative toxicity and a decreasing occurrence of adverse events over time. Eculizumab has a substantial impact on the symptoms and complications of PNH and results a significant improvement in patient survival.
307 citations
••
TL;DR: A step-by-step approach to critiquing quantitative research to help nurses demystify the process and decode the terminology.
Abstract: As with a quantitative study, critical analysis of a qualitative study involves an in-depth review of how each step of the research was undertaken. Qualitative and quantitative studies are, however, fundamentally different approaches to research and therefore need to be considered differently with regard to critiquing. The different philosophical underpinnings of the various qualitative research methods generate discrete ways of reasoning and distinct terminology; however, there are also many similarities within these methods. Because of this and its subjective nature, qualitative research it is often regarded as more difficult to critique. Nevertheless, an evidenced-based profession such as nursing cannot accept research at face value, and nurses need to be able to determine the strengths and limitations of qualitative as well as quantitative research studies when reviewing the available literature on a topic.
306 citations
Authors
Showing all 20853 results
Name | H-index | Papers | Citations |
---|---|---|---|
Edward Giovannucci | 206 | 1671 | 179875 |
Robin M. Murray | 171 | 1539 | 116362 |
Mark E. Cooper | 158 | 1463 | 124887 |
Stephen J. O'Brien | 153 | 1062 | 93025 |
Amartya Sen | 149 | 689 | 141907 |
Kevin Murphy | 146 | 728 | 120475 |
Peter M. Visscher | 143 | 694 | 118115 |
Mihai G. Netea | 142 | 1170 | 86908 |
Kristine Yaffe | 136 | 794 | 72250 |
Cisca Wijmenga | 136 | 668 | 86572 |
David A. Jackson | 136 | 1095 | 68352 |
Patrick F. Sullivan | 133 | 594 | 92298 |
Thomas N. Williams | 132 | 1145 | 95109 |
Paul Brennan | 132 | 1221 | 72748 |
David Taylor | 131 | 2469 | 93220 |