Institution
Trinity College, Dublin
Education•Dublin, Dublin, Ireland•
About: Trinity College, Dublin is a education organization based out in Dublin, Dublin, Ireland. It is known for research contribution in the topics: Population & Context (language use). The organization has 20576 authors who have published 48296 publications receiving 1780313 citations.
Topics: Population, Context (language use), Irish, Health care, Mental health
Papers published on a yearly basis
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TL;DR: The results suggest that providing environmental support to one aspect of executive function may facilitate monitoring and behavioural flexibility--and therefore the useful expression of other skills that may be relatively intact.
301 citations
University of Iceland1, Lancaster University2, Royal Institute of Technology3, European Science Foundation4, Stockholm Resilience Centre5, International Social Science Council6, Trinity College, Dublin7, Environmental Change Institute8, École Normale Supérieure9, Charles III University of Madrid10, University of Strasbourg11
TL;DR: In this article, the authors formulate the need for an innovative research agenda based on a careful consideration of the changing human condition as linked to global environmental change, and call for a meaningful research agenda to acknowledge the profound implications of the advent of the Anthropocene epoch.
301 citations
TL;DR: Phylogenetic analysis suggests that at least two regulatory uORFs in SLC35A4 and MIEF1 encode functional protein products, and site-specific mutagenesis of two identified stress resistant mRNAs demonstrated that a single uORF is sufficient for eIF2-mediated translation control in both cases.
Abstract: Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions. This can be achieved by the phosphorylation-mediated inactivation of a key translation initiation factor, eukaryotic initiation factor 2 (eIF2). However, the persistent translation of certain mRNAs is required for deployment of an adequate stress response. We carried out ribosome profiling of cultured human cells under conditions of severe stress induced with sodium arsenite. Although this led to a 5.4-fold general translational repression, the protein coding open reading frames (ORFs) of certain individual mRNAs exhibited resistance to the inhibition. Nearly all resistant transcripts possess at least one efficiently translated upstream open reading frame (uORF) that represses translation of the main coding ORF under normal conditions. Site-specific mutagenesis of two identified stress resistant mRNAs (PPP1R15B and IFRD1) demonstrated that a single uORF is sufficient for eIF2-mediated translation control in both cases. Phylogenetic analysis suggests that at least two regulatory uORFs (namely, in SLC35A4 and MIEF1) encode functional protein products.
301 citations
TL;DR: An overview of qualitative descriptive research is provided, orientates to the underlying philosophical perspectives and key characteristics that define this approach and identifies the implications for healthcare practice and policy.
Abstract: BackgroundQualitative descriptive designs are common in nursing and healthcare research due to their inherent simplicity, flexibility and utility in diverse healthcare contexts. However, the applic...
301 citations
Posted Content•
TL;DR: In this article, the relationship between international payments and the real exchange rate is studied and a model yielding testable implications on the long-run co-movements of real exchange rates, external positions, relative GDP and terms of trade, and cross-country and time-series evidence on the subject.
Abstract: The relationship between international payments and the real exchange rate--the transfer problem--is a classic question in international economics. We use new data on countries' net external positions together with real exchange rate data to shed light on this question. We present a model yielding testable implications on the long-run co-movements of real exchange rates, external positions, relative GDP and terms of trade, and cross-country and time-series evidence on the subject. Countries with net external liabilities are found to have more depreciated real exchange rates, with the main channel of transmission working through the relative price of nontraded goods.
301 citations
Authors
Showing all 20853 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Edward Giovannucci | 206 | 1671 | 179875 |
| Robin M. Murray | 171 | 1539 | 116362 |
| Mark E. Cooper | 158 | 1463 | 124887 |
| Stephen J. O'Brien | 153 | 1062 | 93025 |
| Amartya Sen | 149 | 689 | 141907 |
| Kevin Murphy | 146 | 728 | 120475 |
| Peter M. Visscher | 143 | 694 | 118115 |
| Mihai G. Netea | 142 | 1170 | 86908 |
| Kristine Yaffe | 136 | 794 | 72250 |
| Cisca Wijmenga | 136 | 668 | 86572 |
| David A. Jackson | 136 | 1095 | 68352 |
| Patrick F. Sullivan | 133 | 594 | 92298 |
| Thomas N. Williams | 132 | 1145 | 95109 |
| Paul Brennan | 132 | 1221 | 72748 |
| David Taylor | 131 | 2469 | 93220 |