Institution
Trinity College, Dublin
Education•Dublin, Dublin, Ireland•
About: Trinity College, Dublin is a education organization based out in Dublin, Dublin, Ireland. It is known for research contribution in the topics: Population & Context (language use). The organization has 20576 authors who have published 48296 publications receiving 1780313 citations.
Topics: Population, Context (language use), Irish, Health care, Mental health
Papers published on a yearly basis
Papers
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TL;DR: The results indicate that stress exists for students in both the clinical and academic aspects of the programme, and financial constraints and academic-related concerns emerged as the most stressful areas for students.
291 citations
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TL;DR: Several proteins, including Triad3A and TAG appear to be involved in the movement of TLR4 to the lysosome for degradation, which results in downregulation of signaling following ligand stimulation.
291 citations
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TL;DR: It is found that the P300 reaches a stereotyped amplitude immediately prior to response execution and that its rate of rise scales with target detection difficulty and accounts for trial‐to‐trial variance in RT.
Abstract: The P300 component of the human event-related potential has been the subject of intensive experimental investigation across a five-decade period, owing to its apparent relevance to a wide range of cognitive functions and its sensitivity to numerous brain disorders, yet its exact contribution to cognition remains unresolved. Here, we carry out key analyses of the P300 elicited by transient auditory and visual targets to examine its potential role as a ‘decision variable’ signal that accumulates evidence to a decision bound. Consistent with the latter, we find that the P300 reaches a stereotyped amplitude immediately prior to response execution and that its rate of rise scales with target detection difficulty and accounts for trial-to-trial variance in RT. Computational simulations of an accumulation-to-bound decision process faithfully captured P300 dynamics when its parameters were set by model fits to the RT distributions. Thus, where the dominant explanatory accounts have conceived of the P300 as a unitary neural event, our data reveal it to be a dynamically evolving neural signature of decision formation. These findings place the P300 at the heart of a mechanistically principled framework for understanding decision-making in both the typical and atypical human brain.
291 citations
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TL;DR: Menning et al. as mentioned in this paper proposed a global Stratigraphic Reference Scale (GSS) for the analysis of the evolution of the Late Palaeozoic in the light of sedimentary geochemistry.
291 citations
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TL;DR: This review focuses in on a trio of miRNAs which have proven to be key in many immune and inflammatory pathways; miR-155,miR-21 and miR -146.
Abstract: Toll-like receptors (TLRs) in the host recognize conserved microbial products and defend against pathogenic attack by initiating an immune response via signalling pathways that lead to an increase in immune and inflammatory gene expression. TLR signalling must be stringently regulated in order to ensure sufficient clearance of pathogens and a timely return to homeostasis after infection. MicroRNAs (miRNAs) are a newly discovered class of gene regulators which bind to the 3# untranslated region of target mRNA and direct their post-transcriptional repression. They are global regulators potentially controlling up to 30% of the human genome. Several miRNAs have been shown to be up-regulated in response to TLR ligands, and many directly target components of the TLR signalling system, revealing a whole extra level of control of TLR signalling which is being extensively researched. The dysregulation of miRNAs may be involved in many inflammatory diseases and cancers and thus merits further investigation. In this review, we focus in on a trio of miRNA which have proven to be key in many immune and inflammatory pathways; miR-155, miR-21 and miR-146.
291 citations
Authors
Showing all 20853 results
Name | H-index | Papers | Citations |
---|---|---|---|
Edward Giovannucci | 206 | 1671 | 179875 |
Robin M. Murray | 171 | 1539 | 116362 |
Mark E. Cooper | 158 | 1463 | 124887 |
Stephen J. O'Brien | 153 | 1062 | 93025 |
Amartya Sen | 149 | 689 | 141907 |
Kevin Murphy | 146 | 728 | 120475 |
Peter M. Visscher | 143 | 694 | 118115 |
Mihai G. Netea | 142 | 1170 | 86908 |
Kristine Yaffe | 136 | 794 | 72250 |
Cisca Wijmenga | 136 | 668 | 86572 |
David A. Jackson | 136 | 1095 | 68352 |
Patrick F. Sullivan | 133 | 594 | 92298 |
Thomas N. Williams | 132 | 1145 | 95109 |
Paul Brennan | 132 | 1221 | 72748 |
David Taylor | 131 | 2469 | 93220 |