Institution
Trinity College, Dublin
Education•Dublin, Dublin, Ireland•
About: Trinity College, Dublin is a education organization based out in Dublin, Dublin, Ireland. It is known for research contribution in the topics: Population & Context (language use). The organization has 20576 authors who have published 48296 publications receiving 1780313 citations.
Topics: Population, Context (language use), Irish, Health care, Mental health
Papers published on a yearly basis
Papers
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TL;DR: The influence of the functional groups grafted to the surface of the BNNSs is investigated by demonstrating the impact on mechanical properties of both noncovalent and covalent bonding at the interface between the nanofiller and polymer matrixes.
Abstract: The covalent chemical functionalization of exfoliated hexagonal boron–nitride nanosheets (BNNSs) is achieved by the solution-phase oxygen radical functionalization of boron atoms in the h-BN lattice. This involves a two-step procedure to initially covalently graft alkoxy groups to boron atoms and the subsequent hydrolytic defunctionalization of the groups to yield hydroxyl-functionalized BNNSs (OH-BNNSs). Characterization of the functionalized-BNNSs using HR-TEM, Raman, UV–vis, FTIR, NMR, and TGA was performed to investigate both the structure of the BNNSs and the covalent functionalization methodology. OH-BNNSs were used to prepare polymer nanocomposites and their mechanical properties analyzed. The influence of the functional groups grafted to the surface of the BNNSs is investigated by demonstrating the impact on mechanical properties of both noncovalent and covalent bonding at the interface between the nanofiller and polymer matrixes.
463 citations
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01 Aug 1996TL;DR: The authors demonstrate a solution to one of the key problems in image watermarking, namely how to hide robust invisible labels inside grey scale or colour digital images.
Abstract: A watermark is an invisible mark placed on an image that is designed to identify both the source of an image as well as its intended recipient. The authors present an overview of watermarking techniques and demonstrate a solution to one of the key problems in image watermarking, namely how to hide robust invisible labels inside grey scale or colour digital images.
462 citations
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TL;DR: The apoptosis-associated caspases cascade and the hierarchy of caspase activation events within it are discussed and caspasing-3 may perform an important role in propagating the caspased cascade, in addition to its role as an effector casp enzyme within the death programme.
Abstract: Caspases participate in the molecular control of apoptosis in several guises; as triggers of the death machinery, as regulatory elements within it, and ultimately as a subset of the effector elements of the machinery itself. The mammalian caspase family is steadily growing and currently contains 14 members. At present, it is unclear whether all of these proteases participate in apoptosis. Thus, current research in this area is focused upon establishing the repertoire and order of caspase activation events that occur during the signalling and demolition phases of cell death. Evidence is accumulating to suggest that proximal caspase activation events are typically initiated by molecules that promote caspase aggregation. As expected, distal caspase activation events are likely to be controlled by caspases activated earlier in the cascade. However, recent data has cast doubt upon the functional demarcation of caspases into signalling (upstream) and effector (downstream) roles based upon their prodomain lengths. In particular, caspase-3 may perform an important role in propagating the caspase cascade, in addition to its role as an effector caspase within the death programme. Here, we discuss the apoptosis-associated caspase cascade and the hierarchy of caspase activation events within it.
462 citations
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F. Kyle Satterstrom1, Jack A. Kosmicki1, Jiebiao Wang2, Michael S. Breen3 +150 more•Institutions (45)
TL;DR: Using an enhanced Bayesian framework to integrate de novo and case-control rare variation, 102 risk genes are identified at a false discovery rate of ≤ 0.1, consistent with multiple paths to an excitatory/inhibitory imbalance underlying ASD.
Abstract: We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n=35,584 total samples, 11,986 with ASD). Using an enhanced Bayesian framework to integrate de novo and case-control rare variation, we identify 102 risk genes at a false discovery rate ≤ 0.1. Of these genes, 49 show higher frequencies of disruptive de novo variants in individuals ascertained for severe neurodevelopmental delay, while 53 show higher frequencies in individuals ascertained for ASD; comparing ASD cases with mutations in these groups reveals phenotypic differences. Expressed early in brain development, most of the risk genes have roles in regulation of gene expression or neuronal communication (i.e., mutations effect neurodevelopmental and neurophysiological changes), and 13 fall within loci recurrently hit by copy number variants. In human cortex single-cell gene expression data, expression of risk genes is enriched in both excitatory and inhibitory neuronal lineages, consistent with multiple paths to an excitatory/inhibitory imbalance underlying ASD.
461 citations
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TL;DR: The most up-to-date progress on TMN-based nanomaterials is comprehensively reviewed, focusing on geometric-st structure design, electronic-structure engineering, and applications in electrochemical energy conversion and storage, including electrocatalysis, supercapacitors, and rechargeable batteries.
Abstract: Transition metal nitrides (TMNs), by virtue of their unique electronic structure, high electrical conductivity, superior chemical stability, and excellent mechanical robustness, have triggered tremendous research interest over the past decade, and showed great potential for electrochemical energy conversion and storage. However, bulk TMNs usually suffer from limited numbers of active sites and sluggish ionic kinetics, and eventually ordinary electrochemical performance. Designing nanostructured TMNs with tailored morphology and good dispersity has proved an effective strategy to address these issues, which provides a larger specific surface area, more abundant active sites, and shorter ion and mass transport distances over the bulk counterparts. Herein, the most up-to-date progress on TMN-based nanomaterials is comprehensively reviewed, focusing on geometric-structure design, electronic-structure engineering, and applications in electrochemical energy conversion and storage, including electrocatalysis, supercapacitors, and rechargeable batteries. Finally, we outline the future challenges of TMN-based nanomaterials and their possible research directions beyond electrochemical energy applications.
461 citations
Authors
Showing all 20853 results
Name | H-index | Papers | Citations |
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Edward Giovannucci | 206 | 1671 | 179875 |
Robin M. Murray | 171 | 1539 | 116362 |
Mark E. Cooper | 158 | 1463 | 124887 |
Stephen J. O'Brien | 153 | 1062 | 93025 |
Amartya Sen | 149 | 689 | 141907 |
Kevin Murphy | 146 | 728 | 120475 |
Peter M. Visscher | 143 | 694 | 118115 |
Mihai G. Netea | 142 | 1170 | 86908 |
Kristine Yaffe | 136 | 794 | 72250 |
Cisca Wijmenga | 136 | 668 | 86572 |
David A. Jackson | 136 | 1095 | 68352 |
Patrick F. Sullivan | 133 | 594 | 92298 |
Thomas N. Williams | 132 | 1145 | 95109 |
Paul Brennan | 132 | 1221 | 72748 |
David Taylor | 131 | 2469 | 93220 |