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Institution

Trinity College, Dublin

EducationDublin, Dublin, Ireland
About: Trinity College, Dublin is a education organization based out in Dublin, Dublin, Ireland. It is known for research contribution in the topics: Population & Context (language use). The organization has 20576 authors who have published 48296 publications receiving 1780313 citations.


Papers
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Journal ArticleDOI
A. Abada1, Marcello Abbrescia2, Marcello Abbrescia3, Shehu S. AbdusSalam4  +1496 moreInstitutions (238)
TL;DR: In this paper, the authors describe the detailed design and preparation of a construction project for a post-LHC circular energy frontier collider in collaboration with national institutes, laboratories and universities worldwide, and enhanced by a strong participation of industrial partners.
Abstract: Particle physics has arrived at an important moment of its history. The discovery of the Higgs boson, with a mass of 125 GeV, completes the matrix of particles and interactions that has constituted the “Standard Model” for several decades. This model is a consistent and predictive theory, which has so far proven successful at describing all phenomena accessible to collider experiments. However, several experimental facts do require the extension of the Standard Model and explanations are needed for observations such as the abundance of matter over antimatter, the striking evidence for dark matter and the non-zero neutrino masses. Theoretical issues such as the hierarchy problem, and, more in general, the dynamical origin of the Higgs mechanism, do likewise point to the existence of physics beyond the Standard Model. This report contains the description of a novel research infrastructure based on a highest-energy hadron collider with a centre-of-mass collision energy of 100 TeV and an integrated luminosity of at least a factor of 5 larger than the HL-LHC. It will extend the current energy frontier by almost an order of magnitude. The mass reach for direct discovery will reach several tens of TeV, and allow, for example, to produce new particles whose existence could be indirectly exposed by precision measurements during the earlier preceding e+e– collider phase. This collider will also precisely measure the Higgs self-coupling and thoroughly explore the dynamics of electroweak symmetry breaking at the TeV scale, to elucidate the nature of the electroweak phase transition. WIMPs as thermal dark matter candidates will be discovered, or ruled out. As a single project, this particle collider infrastructure will serve the world-wide physics community for about 25 years and, in combination with a lepton collider (see FCC conceptual design report volume 2), will provide a research tool until the end of the 21st century. Collision energies beyond 100 TeV can be considered when using high-temperature superconductors. The European Strategy for Particle Physics (ESPP) update 2013 stated “To stay at the forefront of particle physics, Europe needs to be in a position to propose an ambitious post-LHC accelerator project at CERN by the time of the next Strategy update”. The FCC study has implemented the ESPP recommendation by developing a long-term vision for an “accelerator project in a global context”. This document describes the detailed design and preparation of a construction project for a post-LHC circular energy frontier collider “in collaboration with national institutes, laboratories and universities worldwide”, and enhanced by a strong participation of industrial partners. Now, a coordinated preparation effort can be based on a core of an ever-growing consortium of already more than 135 institutes worldwide. The technology for constructing a high-energy circular hadron collider can be brought to the technology readiness level required for constructing within the coming ten years through a focused R&D programme. The FCC-hh concept comprises in the baseline scenario a power-saving, low-temperature superconducting magnet system based on an evolution of the Nb3Sn technology pioneered at the HL-LHC, an energy-efficient cryogenic refrigeration infrastructure based on a neon-helium (Nelium) light gas mixture, a high-reliability and low loss cryogen distribution infrastructure based on Invar, high-power distributed beam transfer using superconducting elements and local magnet energy recovery and re-use technologies that are already gradually introduced at other CERN accelerators. On a longer timescale, high-temperature superconductors can be developed together with industrial partners to achieve an even more energy efficient particle collider or to reach even higher collision energies.The re-use of the LHC and its injector chain, which also serve for a concurrently running physics programme, is an essential lever to come to an overall sustainable research infrastructure at the energy frontier. Strategic R&D for FCC-hh aims at minimising construction cost and energy consumption, while maximising the socio-economic impact. It will mitigate technology-related risks and ensure that industry can benefit from an acceptable utility. Concerning the implementation, a preparatory phase of about eight years is both necessary and adequate to establish the project governance and organisation structures, to build the international machine and experiment consortia, to develop a territorial implantation plan in agreement with the host-states’ requirements, to optimise the disposal of land and underground volumes, and to prepare the civil engineering project. Such a large-scale, international fundamental research infrastructure, tightly involving industrial partners and providing training at all education levels, will be a strong motor of economic and societal development in all participating nations. The FCC study has implemented a set of actions towards a coherent vision for the world-wide high-energy and particle physics community, providing a collaborative framework for topically complementary and geographically well-balanced contributions. This conceptual design report lays the foundation for a subsequent infrastructure preparatory and technical design phase.

425 citations

Journal ArticleDOI
TL;DR: In this paper, the Coulomb and spin-dependent potentials localize the electrons in wave packets that are large on the scale of the Mn-Mn separation transport in the magnetically localized state involves zero point-energy assisted hopping or tunneling of electrons from one weakly localized wave packet to another.
Abstract: Mixed-valence manganites $({{A}^{3+}}_{07}{{B}^{2+}}_{03})\mathrm{Mn}{\mathrm{O}}_{3}$ exhibit a resistivity peak with giant negative magnetoresistance below the Curie point Residual resistivity ranges from 5\ifmmode\times\else\texttimes\fi{}${10}^{\ensuremath{-}8}$ to 8\ifmmode\times\else\texttimes\fi{}${10}^{3}$ \ensuremath{\Omega} m, but the electronic heat capacity when $A=\mathrm{Y}\mathrm{or}\mathrm{La}$ is that of a normal $d$-band metal; $\ensuremath{\gamma}\ensuremath{\approx}6$ mJ ${\mathrm{mole}}^{\ensuremath{-}1}$${\mathrm{K}}^{\ensuremath{-}2}$ Spatial fluctuations in the Coulomb and spin-dependent potentials localize the ${e}_{g}\ensuremath{\uparrow}({\ensuremath{\sigma}}^{*})$ electrons in wave packets that are large on the scale of the Mn-Mn separation Transport in the magnetically localized state involves zero-point-energy assisted hopping or tunneling of electrons from one weakly localized wave packet to another

425 citations

Journal ArticleDOI
20 Feb 2014-Immunity
TL;DR: Understanding the daily rhythm of the immune system could have implications for vaccinations and how the authors manage infectious and inflammatory diseases.

424 citations

Journal ArticleDOI
TL;DR: During alterations in arterial carbon dioxide and oxygen, the large arteries changed diameter and blood flow to the brainstem changed more than that to the cortex.
Abstract: Despite the importance of blood flow on brainstem control of respiratory and autonomic function, little is known about regional cerebral blood flow (CBF) during changes in arterial blood gases.We quantified: (1) anterior and posterior CBF and reactivity through a wide range of steady-state changes in the partial pressures of CO2 (PaCO2) and O2 (PaO2) in arterial blood, and (2) determined if the internal carotid artery (ICA) and vertebral artery (VA) change diameter through the same range.We used near-concurrent vascular ultrasound measures of flow through the ICA and VA, and blood velocity in their downstream arteries (the middle (MCA) and posterior (PCA) cerebral arteries). Part A (n =16) examined iso-oxic changes in PaCO2, consisting of three hypocapnic stages (PaCO2 =∼15, ∼20 and ∼30 mmHg) and four hypercapnic stages (PaCO2 =∼50, ∼55, ∼60 and ∼65 mmHg). In Part B (n =10), during isocapnia, PaO2 was decreased to ∼60, ∼44, and ∼35 mmHg and increased to ∼320 mmHg and ∼430 mmHg. Stages lasted ∼15 min. Intra-arterial pressure was measured continuously; arterial blood gases were sampled at the end of each stage. There were three principal findings. (1) Regional reactivity: the VA reactivity to hypocapnia was larger than the ICA, MCA and PCA; hypercapnic reactivity was similar.With profound hypoxia (35 mmHg) the relative increase in VA flow was 50% greater than the other vessels. (2) Neck vessel diameters: changes in diameter (∼25%) of the ICA was positively related to changes in PaCO2 (R2, 0.63±0.26; P<0.05); VA diameter was unaltered in response to changed PaCO2 but yielded a diameter increase of +9% with severe hypoxia. (3) Intra- vs. extra-cerebral measures: MCA and PCA blood velocities yielded smaller reactivities and estimates of flow than VA and ICA flow. The findings respectively indicate: (1) disparate blood flow regulation to the brainstem and cortex; (2) cerebrovascular resistance is not solely modulated at the level of the arteriolar pial vessels; and (3) transcranial Doppler ultrasound may underestimate measurements of CBF during extreme hypoxia and/or hypercapnia.

423 citations

Journal ArticleDOI
TL;DR: In the first C3 Glomerulopathy Meeting as discussed by the authors, an invited group of experts in renal pathology, nephrology, complement biology, and complement therapeutics met to discuss the definition of C3 glomerular pathology, appropriate complement investigations that should be performed in these patients, and how complement therapies should be explored in the condition.

422 citations


Authors

Showing all 20853 results

NameH-indexPapersCitations
Edward Giovannucci2061671179875
Robin M. Murray1711539116362
Mark E. Cooper1581463124887
Stephen J. O'Brien153106293025
Amartya Sen149689141907
Kevin Murphy146728120475
Peter M. Visscher143694118115
Mihai G. Netea142117086908
Kristine Yaffe13679472250
Cisca Wijmenga13666886572
David A. Jackson136109568352
Patrick F. Sullivan13359492298
Thomas N. Williams132114595109
Paul Brennan132122172748
David Taylor131246993220
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023123
2022370
20213,661
20203,353
20192,875
20182,709