University of Bologna

About: University of Bologna is a education organization based out in Bologna, Emilia-Romagna, Italy. It is known for research contribution in the topics: Population & Galaxy. The organization has 38387 authors who have published 115176 publications receiving 3460869 citations. The organization is also known as: Università di Bologna & UNIBO.

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

Abstract: In recent years, organocatalysis has enhanced its importance as a tool for the synthesis of enantiomerically enriched compounds. Among the candidates for organocatalysis, the construction of asymmetric quaternary carbons is regarded as a challenging problem in organic synthesis. In particular, 3,3′-disubstituted oxindoles have one or more asymmetric quaternary carbon atoms and they represent a large family of bioactive compounds and synthetic derivatives that mimicry natural products. Therefore they are good targets for drug candidates and in the last two years many papers have appeared on organocatalytic methods for the synthesis of 3,3′-disubstituted oxindoles. Moreover, in the last few years 2-substituted and 2,2′-disubtituted 3-indolinones have also attracted the interest of chemists. This review aims to cover the literature on these topics from its origin to the end of 2011.

The Skew-Normal and Related Families

Abstract: Preface 1. Modulation of symmetric densities 2. The skew-normal distribution: probability 3. The skew-normal distribution: statistics 4. Heavy and adaptive tails 5. The multivariate skew-normal distribution 6. Skew-elliptical distributions 7. Further extensions and other directions 8. Application-oriented work Appendices References.

Heterogeneity of patients with intermediate (BCLC B) Hepatocellular Carcinoma: proposal for a subclassification to facilitate treatment decisions.

Abstract: The intermediate stage of hepatocellular carcinoma (HCC) comprises a highly heterogeneous patient population and therefore poses unique challenges for therapeutic management, different from the early and advanced stages. Patients classified as having intermediate HCC by the Barcelona Clinic Liver Cancer (BCLC) staging system present with varying tumor burden and liver function. Transarterial chemoembolization (TACE) is currently recommended as the standard of care in this setting, but there is considerable variation in the clinical benefit patients derive from this treatment.In April 2012, a panel of experts convened to discuss unresolved issues surrounding the application of current guidelines when managing patients with intermediate HCC. The meeting explored the applicability of a subclassification system for intermediate HCC patients to tailor therapeutic interventions based on the evidence available to date and expert opinion. The present report summarizes the proposal of the expert panel: four substages of intermediate HCC patients, B1 to B4.

An overview of recovery models and algorithms for real-time railway rescheduling

Abstract: This paper presents an overview of recovery models and algorithms for real-time railway disturbance and disruption management. This area is currently an active research area in Operations Research, including real-time timetable rescheduling and real-time rescheduling of the rolling stock and crew duties. These topics are addressed in this paper. Also research dealing with the integration of more than one rescheduling phase is discussed. Currently, the developed methods have been tested mainly in an experimental setting, thereby showing promising results, both in terms of their solution quality and in terms of their computation times. The application of these models and algorithms in real-life railway systems will be instrumental for increasing the quality of the provided railway services, leading to an increased utilization of the involved railway systems.