Institution
University of Bologna
Education•Bologna, Emilia-Romagna, Italy•
About: University of Bologna is a education organization based out in Bologna, Emilia-Romagna, Italy. It is known for research contribution in the topics: Population & Galaxy. The organization has 38387 authors who have published 115176 publications receiving 3460869 citations. The organization is also known as: Università di Bologna & UNIBO.
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01 Jan 2014TL;DR: In this paper, Dzherbashian [Dzh60] defined a function with positive α 1 > 0, α 2 > 0 and real α 1, β 2, β 3, β 4, β 5, β 6, β 7, β 8, β 9, β 10, β 11, β 12, β 13, β 14, β 15, β 16, β 17, β 18, β 20, β 21, β 22, β 24
Abstract: Consider the function defined for \(\alpha _{1},\ \alpha _{2} \in \mathbb{R}\) (α 1 2 +α 2 2 ≠ 0) and \(\beta _{1},\beta _{2} \in \mathbb{C}\) by the series
$$\displaystyle{ E_{\alpha _{1},\beta _{1};\alpha _{2},\beta _{2}}(z) \equiv \sum _{k=0}^{\infty } \frac{z^{k}} {\varGamma (\alpha _{1}k +\beta _{1})\varGamma (\alpha _{2}k +\beta _{2})}\ \ (z \in \mathbb{C}). }$$
(6.1.1)
Such a function with positive α 1 > 0, α 2 > 0 and real \(\beta _{1},\beta _{2} \in \mathbb{R}\) was introduced by Dzherbashian [Dzh60].
919 citations
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TL;DR: Using IDLV delivery and ZFNs targeting distinct loci, high levels of gene addition are observed in a panel of human cell lines, as well as human embryonic stem cells, allowing rapid, selection-free isolation of clonogenic cells with the desired genetic modification.
Abstract: Achieving the full potential of zinc-finger nucleases (ZFNs) for genome engineering in human cells requires their efficient delivery to the relevant cell types. Here we exploited the infectivity of integrase-defective lentiviral vectors (IDLV) to express ZFNs and provide the template DNA for gene correction in different cell types. IDLV-mediated delivery supported high rates (13-39%) of editing at the IL-2 receptor common gamma-chain gene (IL2RG) across different cell types. IDLVs also mediated site-specific gene addition by a process that required ZFN cleavage and homologous template DNA, thus establishing a platform that can target the insertion of transgenes into a predetermined genomic site. Using IDLV delivery and ZFNs targeting distinct loci, we observed high levels of gene addition (up to 50%) in a panel of human cell lines, as well as human embryonic stem cells (5%), allowing rapid, selection-free isolation of clonogenic cells with the desired genetic modification.
918 citations
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TL;DR: This molecular elevator is considerably more complex and better organized than previously reported artificial molecular machines and exhibits a clear-cut on-off reversible behavior, and it could develop forces up to around 200 piconewtons.
Abstract: We report the incrementally staged design, synthesis, characterization, and operation of a molecular machine that behaves like a nanoscale elevator. The operation of this device, which is made of a platformlike component interlocked with a trifurcated riglike component and is only 3.5 nanometers by 2.5 nanometers in size, relies on the integration of several structural and functional molecular subunits. This molecular elevator is considerably more complex and better organized than previously reported artificial molecular machines. It exhibits a clear-cut on-off reversible behavior, and it could develop forces up to around 200 piconewtons.
905 citations
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University of Texas MD Anderson Cancer Center1, Catholic University of Korea2, University of South Florida3, Charité4, University of California, Los Angeles5, Singapore General Hospital6, Claude Bernard University Lyon 17, Imperial College London8, Emory University9, University of Michigan10, Washington University in St. Louis11, Harvard University12, University of Rome Tor Vergata13, University of Paris14, University of Bologna15, Heidelberg University16, University of Milano-Bicocca17, ARIAD Pharmaceuticals, Inc.18, University of Poitiers19, University of Utah20, University of Jena21, University of California, San Francisco22
TL;DR: Ponatinib had significant antileukemic activity across categories of disease stage and mutation status and were durable; the estimated rate of a sustained major cytogenetic response of at least 12 months was 91%.
Abstract: Background Ponatinib is a potent oral tyrosine kinase inhibitor of unmutated and mutated BCR-ABL, including BCR-ABL with the tyrosine kinase inhibitor–refractory threonineto-isoleucine mutation at position 315 (T315I). We conducted a phase 2 trial of ponatinib in patients with chronic myeloid leukemia (CML) or Philadelphia chromosome– positive acute lymphoblastic leukemia (Ph-positive ALL). Methods We enrolled 449 heavily pretreated patients who had CML or Ph-positive ALL with resistance to or unacceptable side effects from dasatinib or nilotinib or who had the BCR-ABL T315I mutation. Ponatinib was administered at an initial dose of 45 mg once daily. The median follow-up was 15 months. Results Among 267 patients with chronic-phase CML, 56% had a major cytogenetic response (51% of patients with resistance to or unacceptable side effects from dasatinib or nilotinib and 70% of patients with the T315I mutation), 46% had a complete cytogenetic response (40% and 66% in the two subgroups, respectively), and 34% had a major molecular response (27% and 56% in the two subgroups, respectively). Responses were observed regardless of the baseline BCR-ABL kinase domain mutation status and were durable; the estimated rate of a sustained major cytogenetic response of at least 12 months was 91%. No single BCR-ABL mutation conferring resistance to ponatinib was detected. Among 83 patients with accelerated-phase CML, 55% had a major hematologic response and 39% had a major cytogenetic response. Among 62 patients with blast-phase CML, 31% had a major hematologic response and 23% had a major cytogenetic response. Among 32 patients with Ph-positive ALL, 41% had a major hematologic response and 47% had a major cytogenetic response. Common adverse events were thrombocytopenia (in 37% of patients), rash (in 34%), dry skin (in 32%), and abdominal pain (in 22%). Serious arterial thrombotic events were observed in 9% of patients; these events were considered to be treatment-related in 3%. A total of 12% of patients discontinued treatment because of an adverse event.
897 citations
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TL;DR: A class of hybrid algorithms, of which branch-and-bound and polyhedral outer approximation are the two extreme cases, are proposed and implemented and Computational results that demonstrate the effectiveness of this framework are reported.
891 citations
Authors
Showing all 39076 results
Name | H-index | Papers | Citations |
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Anil K. Jain | 183 | 1016 | 192151 |
H. S. Chen | 179 | 2401 | 178529 |
Stefan Schreiber | 178 | 1233 | 138528 |
Alvio Renzini | 162 | 908 | 95452 |
David H. Adams | 155 | 1613 | 117783 |
Roberto Romero | 151 | 1516 | 108321 |
Thomas E. Starzl | 150 | 1625 | 91704 |
Paolo Boffetta | 148 | 1455 | 93876 |
Kypros H. Nicolaides | 147 | 1302 | 87091 |
J. Fraser Stoddart | 147 | 1239 | 96083 |
Fabio Finelli | 147 | 542 | 111128 |
Jack Hirsh | 146 | 734 | 86332 |
Kjell Fuxe | 142 | 1479 | 89846 |
Andrew Ivanov | 142 | 1812 | 97390 |
Peter Lang | 140 | 1136 | 98592 |