University of Bologna

About: University of Bologna is a education organization based out in Bologna, Emilia-Romagna, Italy. It is known for research contribution in the topics: Population & Galaxy. The organization has 38387 authors who have published 115176 publications receiving 3460869 citations. The organization is also known as: Università di Bologna & UNIBO.

Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium

Abstract: Mucormycosis is a difficult to diagnose rare disease with high morbidity and mortality. Diagnosis is often delayed, and disease tends to progress rapidly. Urgent surgical and medical intervention is lifesaving. Guidance on the complex multidisciplinary management has potential to improve prognosis, but approaches differ between health-care settings. From January, 2018, authors from 33 countries in all United Nations regions analysed the published evidence on mucormycosis management and provided consensus recommendations addressing differences between the regions of the world as part of the "One World One Guideline" initiative of the European Confederation of Medical Mycology (ECMM). Diagnostic management does not differ greatly between world regions. Upon suspicion of mucormycosis appropriate imaging is strongly recommended to document extent of disease and is followed by strongly recommended surgical intervention. First-line treatment with high-dose liposomal amphotericin B is strongly recommended, while intravenous isavuconazole and intravenous or delayed release tablet posaconazole are recommended with moderate strength. Both triazoles are strongly recommended salvage treatments. Amphotericin B deoxycholate is recommended against, because of substantial toxicity, but may be the only option in resource limited settings. Management of mucormycosis depends on recognising disease patterns and on early diagnosis. Limited availability of contemporary treatments burdens patients in low and middle income settings. Areas of uncertainty were identified and future research directions specified.

Ranging With Ultrawide Bandwidth Signals in Multipath Environments

Abstract: Over the coming decades, high-definition situationally-aware networks have the potential to create revolutionary applications in the social, scientific, commercial, and military sectors Ultrawide bandwidth (UWB) technology is a viable candidate for enabling accurate localization capabilities through time-of-arrival (TOA)-based ranging techniques These techniques exploit the fine delay resolution property of UWB signals by estimating the TOA of the first signal path Exploiting the full capabilities of UWB TOA estimation can be challenging, especially when operating in harsh propagation environments, since the direct path may not exist or it may not be the strongest In this paper, we first give an overview of ranging techniques together with the primary sources of TOA error (including propagation effects, clock drift, and interference) We then describe fundamental TOA bounds (such as the Cramer-Rao bound and the tighter Ziv-Zakai bound) in both ideal and multipath environments These bounds serve as useful benchmarks in assessing the performance of TOA estimation techniques We also explore practical low-complexity TOA estimation techniques and analyze their performance in the presence of multipath and interference using IEEE 802154a channel models as well as experimental data measured in indoor residential environments

Reappraisal of European guidelines on hypertension management:: A European Society of Hypertension Task Force document

Abstract: ACEangiotensin-converting enzymeBPblood pressureDBPdiastolic blood pressureeGFRestimated glomerular filtration rateESCEuropean Society of CardiologyESHEuropean Society of HypertensionETendothelinIM...

Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity

Abstract: The fundamental event in prion diseases seems to be a conformational change in cellular prion protein (PrPC) whereby it is converted into the pathologic isoform PrPSc. In fatal familial insomnia (FFI), the protease-resistant fragment of PrPSc after deglycosylation has a size of 19 kilodaltons, whereas that from other inherited and sporadic prion diseases is 21 kilodaltons. Extracts from the brains of FFI patients transmitted disease to transgenic mice expressing a chimeric human-mouse PrP gene about 200 days after inoculation and induced formation of the 19-kilodalton PrPSc fragment, whereas extracts from the brains of familial and sporadic Creutzfeldt-Jakob disease patients produced the 21-kilodalton PrPSc fragment in these mice. The results presented indicate that the conformation of PrPSc functions as a template in directing the formation of nascent PrPSc and suggest a mechanism to explain strains of prions where diversity is encrypted in the conformation of PrPSc.

New exponential bounds and approximations for the computation of error probability in fading channels

Abstract: We present new exponential bounds for the Gaussian Q function (one- and two-dimensional) and its inverse, and for M-ary phase-shift-keying (MPSK), M-ary differential phase-shift-keying (MDPSK) error probabilities over additive white Gaussian noise channels. More precisely, the new bounds are in the form of the sum of exponential functions that, in the limit, approach the exact value. Then, a quite accurate and simple approximate expression given by the sum of two exponential functions is reported. The results are applied to the general problem of evaluating the average error probability in fading channels. Some examples of applications are also presented for the computation of the pairwise error probability of space-time codes and the average error probability of MPSK and MDPSK in fading channels.