Institution
University of Graz
Education•Graz, Steiermark, Austria•
About: University of Graz is a education organization based out in Graz, Steiermark, Austria. It is known for research contribution in the topics: Population & Context (language use). The organization has 17934 authors who have published 37489 publications receiving 1110980 citations. The organization is also known as: Carolo Franciscea Graecensis & Karl Franzens Universität.
Papers published on a yearly basis
Papers
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TL;DR: In spruce (Picea abies) needles glutathion and glutathione reductase show a periodic seasonal variation with significantly increased levels during the winter, which is proposed to play an important role for the winter hardiness of leaves from evergreen plants.
Abstract: In spruce (Picea abies) needles glutathione and glutathione reductase show a periodic seasonal variation with significantly increased levels during the winter. It is proposed that glutathione and glutathione reductase play an important role for the winter hardiness of leaves from evergreen plants.
317 citations
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TL;DR: In this article, the authors present the "Drag-Based Model" (DBM) of heliospheric propagation of interplanetary coronal mass ejections (ICMEs) based on the hypothesis that the driving Lorentz force, which launches a CME, ceases in the upper corona and that beyond a certain distance the dynamics becomes governed by the interaction of the ICME and the ambient solar wind.
Abstract: We present the “Drag-Based Model” (DBM) of heliospheric propagation of interplanetary coronal mass ejections (ICMEs). The DBM is based on the hypothesis that the driving Lorentz force, which launches a CME, ceases in the upper corona and that beyond a certain distance the dynamics becomes governed solely by the interaction of the ICME and the ambient solar wind. In particular, we consider the option where the drag acceleration has a quadratic dependence on the ICME relative speed, which is expected in a collisionless environment, where the drag is caused primarily by emission of magnetohydrodynamic (MHD) waves. In this paper we present the simplest version of DBM, where the equation of motion can be solved analytically, providing explicit solutions for the Sun–Earth ICME transit time and impact speed. This offers easy handling and straightforward application to real-time space-weather forecasting. Beside presenting the model itself, we perform an analysis of DBM performances, applying a statistical and case-study approach, which provides insight into the advantages and drawbacks of DBM. Finally, we present a public, DBM-based, online forecast tool.
316 citations
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TL;DR: It is concluded that carriers of a VEGF 936T‐allele are at decreased risk for breast cancer, this, however, requiring further confirmation in a larger study.
Abstract: A common 936 C/T polymorphism in the gene for the vascular endothelial growth factor (VEGF) has been associated with VEGF plasma levels. In our case-control study, we investigated the role of this polymorphism for breast cancer risk. VEGF genotype was determined in 500 women with breast cancer and 500 sex- and age-matched healthy control subjects. Carriers of a 936T-allele were more frequent among controls (29.4%) than among patients (17.6%; p = 0.000014). The odds ratio for carriers of a 936T-allele for breast cancer was 0.51 (95% confidence interval 0.38-0.70). Additionally, VEGF plasma levels were determined in 21 nonsmoking post-menopausal controls; carriers of a 936T allele had significantly lower levels (median 23 pg/ml; range 6-50 pg/ml) than noncarriers (37; 21-387; p = 0.034). We conclude that carriers of a VEGF 936T-allele are at decreased risk for breast cancer, this, however, requiring further confirmation in a larger study.
316 citations
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TL;DR: It is demonstrated that DDC feeding in mice leads to a reactive phenotype of cholangiocytes and bile duct injury, pericholangitis, periductal fibrosis, ductular reaction, and consequently portal-portal bridging, and down-regulation of Mrp2 and impaired glutathione excretion, which may be valuable to investigate the mechanisms of xenobiotic-induced chronicCholangiopathies and its sequels including biliary fibrosis.
Abstract: Xenobiotics and drugs may lead to cholangiopathies and biliary fibrosis, but the underlying mechanisms are largely unknown. Therefore, we aimed to characterize the cause and consequences of hepatobiliary injury and biliary fibrosis in 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed mice as a novel model of xenobiotic-induced cholangiopathy. Liver morphology, markers of inflammation, cell proliferation, fibrosis, bile formation, biliary porphyrin secretion, and hepatobiliary transporter expression were studied longitudinally in DDC- and control diet-fed Swiss albino mice. DDC feeding led to increased biliary porphyrin secretion and induction of vascular cell adhesion molecule, osteopontin, and tumor necrosis factor-α expression in bile duct epithelial cells. This was associated with a pronounced pericholangitis with a significantly increased number of CD11b-positive cells, ductular reaction, and activation of periductal myofibroblasts, leading to large duct disease and a biliary type of liver fibrosis. After 4 weeks, we constantly observed intraductal porphyrin pigment plugs. Glutathione and phospholipid excretion significantly decreased over time. Expression of Ntcp, Oatp4, and Mrp2 was significantly reduced, whereas Bsep expression remained unchanged and adaptive Mrp3 and Mrp4 expression was significantly induced. We demonstrate that DDC feeding in mice leads to i) a reactive phenotype of cholangiocytes and bile duct injury, ii) pericholangitis, periductal fibrosis, ductular reaction, and consequently portal-portal bridging, iii) down-regulation of Mrp2 and impaired glutathione excretion, and iv) segmental bile duct obstruction. This model may be valuable to investigate the mechanisms of xenobiotic-induced chronic cholangiopathies and its sequels including biliary fibrosis.
316 citations
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TL;DR: It would seem conceivable, therefore, that tachykinin agonists and antagonists are adjuncts to the treatment of motor disorders that involve pathological disturbances of the gastrointestinal tachyKinin system.
316 citations
Authors
Showing all 18136 results
Name | H-index | Papers | Citations |
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David Haussler | 172 | 488 | 224960 |
Russel J. Reiter | 169 | 1646 | 121010 |
Frederik Barkhof | 154 | 1449 | 104982 |
Philip Scheltens | 140 | 1175 | 107312 |
Christopher D.M. Fletcher | 138 | 674 | 82484 |
Jennifer S. Haas | 128 | 840 | 71315 |
Jelena Krstic | 126 | 839 | 73457 |
Michael A. Kamm | 124 | 637 | 53606 |
Frances H. Arnold | 119 | 510 | 49651 |
Gert Pfurtscheller | 117 | 507 | 62873 |
Georg Kresse | 111 | 430 | 244729 |
Manfred T. Reetz | 110 | 959 | 42941 |
Alois Fürstner | 108 | 459 | 43085 |
David N. Herndon | 108 | 1227 | 54888 |
David J. Williams | 107 | 2060 | 62440 |