University of Iowa

About: University of Iowa is a education organization based out in Iowa City, Iowa, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 49229 authors who have published 109171 publications receiving 5021465 citations. The organization is also known as: UI & The University of Iowa.

The role of person versus situation in life satisfaction: a critical examination.

Abstract: Two main theoretical approaches have been put forward to explain individual differences in life satisfaction: top-down (i.e., personological) and bottom-up (i.e., situational). The authors examine the relative merit of these 2 approaches and the psychological processes underlying top-down models. Consistent with a top-down approach, meta-analytic findings indicate that Neuroticism, Extraversion, Agreeableness, and Conscientiousness are related to both various domain satisfactions and life satisfaction; however, consistent with a bottom-up approach, domain satisfactions are strongly linked to life satisfaction but only weakly linked to each other. Path analyses based on meta-analytic estimates did not support a simple "direct-effects" top-down model but supported both (a) a temperament-based top-down model and (b) an integrative model that incorporates the direct influence of domain satisfactions on life satisfaction.

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis

Abstract: Juvenile polyposis (JP; OMIM 174900) is an autosomal dominant gastrointestinal hamartomatous polyposis syndrome in which patients are at risk for developing gastrointestinal cancers1,2. Previous studies have demonstrated a locus for JP mapping to 18q21.1 (ref. 3) and germline mutations in the homolog of the gene for mothers against decapentaplegic, Drosophila, (MADH4, also known as SMAD4) in several JP families4. However, mutations in MADH4 are only present in a subset of JP cases5, and although mutations in the gene for phosphatase and tensin homolog (PTEN) have been described in a few families6,7, undefined genetic heterogeneity remains. Using a genome-wide screen in four JP kindreds without germline mutations in MADH4 or PTEN, we identified linkage with markers from chromosome 10q22–23 (maximum lod score of 4.74, θ=0.00). We found no recombinants using markers developed from the vicinity of the gene for bone morphogenetic protein receptor 1A (BMPR1A), a serine–threonine kinase type I receptor involved in bone morphogenetic protein (BMP) signaling8. Genomic sequencing of BMPR1A in each of these JP kindreds disclosed germline nonsense mutations in all affected kindred members but not in normal control individuals. These findings indicate involvement of an additional gene in the transforming growth factor-β (TGF-β) superfamily in the genesis of JP, and document an unanticipated function for BMP in colonic epithelial growth control.

Timescale for radiation belt electron acceleration by whistler mode chorus waves

Abstract: [1] Electron acceleration inside the Earth's magnetosphere is required to explain increases in the ∼MeV radiation belt electron flux during magnetically disturbed periods. Recent studies show that electron acceleration by whistler mode chorus waves becomes most efficient just outside the plasmapause, near L = 4.5, where peaks in the electron phase space density are observed. We present CRRES data on the spatial distribution of chorus emissions during active conditions. The wave data are used to calculate the pitch angle and energy diffusion rates in three magnetic local time (MLT) sectors and to obtain a timescale for acceleration. We show that chorus emissions in the prenoon sector accelerate electrons most efficiently at latitudes above 15° for equatorial pitch angles between 20° and 60°. As electrons drift around the Earth, they are scattered to large pitch angles and further accelerated by chorus on the nightside in the equatorial region. The timescale to accelerate electrons by whistler mode chorus and increase the flux at 1 MeV by an order of magnitude is approximately 1 day, in agreement with satellite observations during the recovery phase of storms. During wave acceleration the electrons undergo many drift orbits and the resulting pitch angle distributions are energy-dependent. Chorus scattering should produce pitch angle distributions that are either flat-topped or butterfly-shaped. The results provide strong support for the wave acceleration theory.

Motile Cilia of Human Airway Epithelia Are Chemosensory

Abstract: Cilia are microscopic projections that extend from eukaryotic cells. There are two general types of cilia; primary cilia serve as sensory organelles, whereas motile cilia exert mechanical force. The motile cilia emerging from human airway epithelial cells propel harmful inhaled material out of the lung. We found that these cells express sensory bitter taste receptors, which localized on motile cilia. Bitter compounds increased the intracellular calcium ion concentration and stimulated ciliary beat frequency. Thus, airway epithelia contain a cell-autonomous system in which motile cilia both sense noxious substances entering airways and initiate a defensive mechanical mechanism to eliminate the offending compound. Hence, like primary cilia, classical motile cilia also contain sensors to detect the external environment.