Showing papers in "Cell Transplantation in 2018"

TL;DR: This review summarizes changes in skin aging, research advances of the molecular mechanisms leading to these changes, and the treatment strategies aimed at preventing or reversing skin aging.

TL;DR: The imbalanced microenvironment of the spinal cord impairs regeneration and functional recovery and this review will aid in the understanding of the pathological processes involved in and the development of comprehensive treatments for SCI.

TL;DR: The pathophysiology, clinical aspects, neuroimaging, progress of research to treat and prevent CSVD and current treatment of this disease are discussed.

TL;DR: Results showed that the supraspinal control of movements below the injury was regained by functional scaffolds implantation in the two patients who were judged as the complete injury with combined criteria, it suggested thatfunctional scaffolds transplantation could serve as an effective treatment for acute complete SCI patients.

TL;DR: The mechanism and therapeutic potential of MSC-derived exosomes in stroke, PD, and OA in basic and clinical aspects are focused on.

TL;DR: The latest progress on ncRNAs in relation to their implications in AIS are reviewed, as well as their potential as diagnostic and prognostic biomarkers and ncRNA acting as possible therapeutic targets in future precision medicine are reviewed.

TL;DR: The immunosuppressive and immunostimulatory activity of amniotic cells will be discussed and, under specific culture conditions, they can stimulate T cell proliferation in vitro.

TL;DR: Intra-renal delivery of MSC-derived EVs bearing pro-angiogenic properties restored the renal microcirculation and in turn hemodynamics and function in chronic experimental MetS+RVD.

TL;DR: The results of the study indicated that hUCB-MSC infusion with basic rehabilitation was safe and effective in improving gross motor and comprehensive functions in children with CP.

TL;DR: Stem cells derived from young tissues, such as umbilical cord–derived MSCs, could slow the post-AKI senescence process and be better at increasing Klotho levels, and thus protecting tissues from senescences, than are adipose-derived M SCs.

TL;DR: This review will focus on MSCs, stem cells widely utilized in current medical research, and evaluate their effect and potential of improving outcomes in ischemic stroke.

TL;DR: Without a robust purification procedure in OEC transplantation therapies, the full potential of OECs for spinal cord injury may not be realised.

TL;DR: The quality of current evidence was assessed, several issues and gaps in translating animal studies to human trials were identified and incorporating changes into future animal studies and human trials may lead to better success of stem cells-based therapeutics in the near future.

TL;DR: Intranasally administered stem cells appear to cross the olfactory epithelium, enter a space adjacent to the periosteum of the turbinate bones, and then enter the SAS via its extensions adjacent toThe fila olfactoria as they cross the cribriform plate.

TL;DR: It is suggested that human Wharton’s jelly MSC (hWJ-MSC)-derived EVs have the potential to prevent and resolve HI-induced apoptosis in neuronal cells in the immature neonatal brain.

TL;DR: Prolonged 40-day in vitro culture duration of iPSC-derived cardiomyocytes revealed progressive cellular hypertrophy; a better-developed contractile apparatus; expression of marker genes similar to human myocardial ventricular cells, including a statistically significant CX43 increase, an MHC isoform switch, and a troponin I isoform transition; more efficient intercellular calcium handling; and a stronger response to β-adrenergic stimulation.

TL;DR: The information about the stroke–miRNA system may be helpful for therapeutic and diagnostic methods in stroke treatment and will explain the complex link between both.

TL;DR: Stem cell therapy showed good therapeutic effect in ICH, making it a promising treatment, however, safety should be carefully evaluated, and more clinical trials are required before stem cell therapy can be extensively applied to clinical use.

TL;DR: Exosomes derived from IDO-BMSCs can be used to promote immunotolerance and prolong the survival of cardiac allografts.

TL;DR: Clinicians and scientists are provided with the most efficient medical options for IPF and it is suggested that MSC transplantation is combined with drug application for synergistic effects to maximize the therapeutic effect.

TL;DR: This review defines the 3 phases of OEC transplantation into the injured spinal cord and the optimal cell behaviors required for each phase and identifies the key growth factors that exhibit the strongest potential for optimizing the OEC phenotype required forEach phase.

TL;DR: It is concluded that a sex dichotomy in pro- and anti-inflammatory response underlies the sex-specific chronic HIE outcomes, and an enhanced neurogenesis in females also contribute to the sex difference.

TL;DR: The roles of pericytes in stroke pathogenesis are summarized, with a focus on their effects in cerebral blood flow, BBB integrity, angiogenesis, immune responses, scar formation and fibrosis.

TL;DR: Before any wider use of hAM for treating urological defects, the protocols for preparation and storage will need to be standardized, followed by more studies on larger animals and clinical trials, which will altogether extensively assess the potential of h amniotic membrane use in Urological patients.

TL;DR: It is demonstrated that preconditioning enhances the immunosuppressive and therapeutic effects of hUCMSCs on treating IBD via increased secretion of PGE2.

TL;DR: IA injection of autologous ASC+HA may demonstrate better efficacy than autOLOGous SVF+HA in blocking OA progression and promoting cartilage regeneration, and autologously ASCs (5×107 cells) combined with HA potentially survive for at least 18 weeks after IA injection.

TL;DR: These guidelines include items of cell type nomenclature, cell quality control, minimal suggested cell doses, patient-informed consent, indications for undergoing cell therapy, contraindications for undergoingcell therapy, documentation of procedure and therapy, safety evaluation, efficacy evaluation, policy of repeated treatments, and publishing responsibility.

TL;DR: The various regulated cell death pathways are reviewed and their relative potential contributions to islet viability, engraftment failure and islet dysfunction are highlighted.

TL;DR: Comparisons of adipose-derived and bone marrow-derived MSCs isolated from individual C57BL6/J mice in relation to cellular characteristics, tolerance to hypoxia, oxidative stress and serum-free conditions, and cellular survival rates indicate that AD-MSCs are an attractive alternative to BM- MSCs for the treatment of severe spinal cord injury.

TL;DR: It is demonstrated that despite failing to undergo myogenesis in vitro, ASCs combined with electrospun fibrin microfibers moderately increased muscle reconstruction in vivo compared with acellular fibers following a severe VML defect.