Showing papers in "Cytokine in 2005"

TL;DR: This study showed for the first time that human epicardial adipose tissue expresses adiponectin, significantly lower in epicardials fat isolated from patients with severe coronary artery disease than in those without CAD.

TL;DR: It was concluded that bovine mammary epithelial cells have a strong but differential capacity to mount innate immune responses to bacterial cell wall components.

TL;DR: IL-28A and IL-29 act similarly to IFNs, but are less effective generally and have activity in a more limited range of cell lines.

TL;DR: The results strongly suggest that cytokine induction and signal transduction are important for the differentiation of CB-MSCs.

TL;DR: Investigating whether sequential measurement of blood interleukin (IL)-6 levels using chemiluminescent enzyme immunoassay (CLEIA) would be useful for the management of patients with systemic inflammatory response syndrome (SIRS)/sepsis found it useful in evaluating the severity and in predicting the outcome of the patients with SIRS/ sepsis.

TL;DR: Among host genetic factors contributing to H. pylori disease outcome, IFN-G +874 AA genotype favors cagA positive infections, TNF-A -857 TT duodenal ulcer while IL-10 -819 TT intestinal metaplasia and NCGC.

TL;DR: Using RT-PCR analysis, the expression levels of cytokines and growth factors from MSCs and their differentiated cell types, including osteoblasts, adipocytes and endothelial cells are examined to help determine future clinical applications of MSCS and their derivatives for cell therapy.

TL;DR: The association of proximal promoter -1082 SNP with IL-10 production is confirmed, and IL10 proximal and distal promoter SNP distribution with estimated haplotype variations has implicated considerable similarities with the Caucasian populations in Turkey.

TL;DR: The data indicate that IL-8 induces cell proliferation and migration by an ADAM-dependent pathway, and that HB-EGF plays an important role as the major ligand for this pathway.

TL;DR: While the cytokine responses to LPS were similar to those induced by the corresponding amount of Gram-negative bacteria, the strong IL-1 beta and TNF-alpha responses to Gram-positive bacteria could not be induced by soluble peptidoglycan or lipotheicoic acid.

TL;DR: The results strongly suggest that the MAPKs/AP-1 and IKK/IkappaB/NF-kappB cascades cooperatively mediate the IL-1beta-stimulated synthesis of IL-6, IL-8, PGE(2) and MMP-1 in HGF.

TL;DR: It is demonstrated here for the first time that the antiinflammatory cytokine IL-10 is secreted by human WAT explants and that it is up-regulated by LPS and TNF-alpha in vitro, as well as in obesity in humans and rodents.

TL;DR: The hypothesis that activation and damage of microvascular endothelial cells (EC) could be induced by inflammatory mediators present in dengue patient's sera is examined and it is found that acute d Dengue sera induced apoptosis in HMEC-1.

TL;DR: The importance of microenvironment in primary ECs that could have important applications in developing targeted therapies for vascular diseases is confirmed, and genes that were reciprocally expressed in response to different cytokines that could serve as markers of inflammatory and immune expression are identified.

TL;DR: In this paper, the effect of pro-inflammatory (i.e. interleukin (IL)-1beta, IL-6, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha) versus anti-inflammatory cytokines was explored during in vitro human adipogenesis.

TL;DR: Experimental studies demonstrate that the mouse provides a valuable experimental surrogate for the human skin immune system, particularly with respect to LC biology, and suggest that it is possible to perform extrapolations between species with some confidence.

TL;DR: It is concluded that reperfusion induces PMN activation, and inhibition of CXCL8 by repertaxin might be of pharmacological interest in transient ischemia.

TL;DR: Data suggest that TL1A and DR3 is involved in atherosclerosis via the induction of pro-inflammatory cytokines/chemokines and decreasing plaque stability by inducing extracellular matrix degrading enzymes.

TL;DR: The results suggest a role of CCL23 in angiogenesis in vitro as well as in vivo, and treatment with either pertussis toxin or anti-CCR1 antibody completely inhibited the CCL 23-induced endothelial cell migration, indicating that endothelialcell migration was mediated through CCR1.

TL;DR: Investigating the mRNA expression profiles of all four PDGF isoforms in transdifferentiating primary cultured hepatic stellate cells found that PDGF receptor-beta (PDGFR-beta) mRNA was rapidly upregulated within the first day of culture and was constantly expressed from day 2 on while the expression profile of PDG FR-alpha mRNA was very similar to that of PDGF-A during transdifferentiation.

TL;DR: Relations between VEGF and IL-18 released by PMN may promote neoangiogenesis and may be important for benign tumour cells to acquire metastatic phenotype in the early stage of oral cavity cancer.

TL;DR: Examination of murine skin samples taken at 0, 3, 12, 18, 24, 48, 72, 120 and 168 h post-wounding revealed that IL-1beta, IP10, bFGF, and TGFbeta3 up-regulated in wounded samples, compared to non-injured control samples.

TL;DR: It is suggested that IL-6 and OSM may play a role in modulating the inflammatory cascade of chronic periodontitis.

TL;DR: The data suggest that hematopoietic cells cooperate with osteoblasts to assemble the various marrow microenvironments by directing the synthesis of osteoblast-derived cytokines to improve HSC survival.

TL;DR: The results suggest that the disruption of NF-kappaB-mediated transactivation plays a significant role in ER inhibition of IL-6 gene expression.

TL;DR: In conclusion, A. actinomycetemcomitans induces IL-6 production in GF by a mechanism largely independent of its Cdt, and RANKL expression in GF occurs independently of IL-1,IL-6, TNF-alpha, or PGE(2).

TL;DR: The responses of sICAM-1 levels to nutrients, physical activity, smoke exposure and alcohol consumption are described to help understand the drivers of atherosclerosis.

TL;DR: The data implicate inflammation in the pathogenesis of diabetic nephropathy in view of the overexpression of the proinflammatory cytokines TNF-alpha and IFN-gamma and the cells that secrete them in the early and late phases of the disease.

TL;DR: Results show that the down-regulation of apolipoprotein A-I and A-IV messages in the liver may be mediated by interleukin 6 and TNF-alpha.

TL;DR: Experimental autoimmune encephalomyelitis is the prototypic T cell-mediated autoimmune disease model, and IL-10 appears to be the dominant cytokine mediating recovery, although studies in knockout mice do not support this paradigm.