Showing papers in "European Journal of Cancer in 2003"

TL;DR: It is now accepted that CUP represents a heterogeneous group of malignancies that share a unique clinical behaviour and, presumably, unique biology.

TL;DR: It is concluded that FDG-PET is an early and sensitive method to evaluate an early response to imatinib treatment and is associated with a longer progression-free survival (PFS) than conventional tomography.

TL;DR: The review discusses why carers fail to take advantage of interventions designed to help them and those who participate derive only limited psychological benefits.

TL;DR: Langerhans cell histiocytosis in adults is most often a multisystem disease with the highest mortality seen in patients with isolated pulmonary involvement, and should be included in the differential diagnosis of disseminated or localised disease of the bone, skin and mucosa, as well as the lung and the endocrine and central nervous system, regardless of the age of the patient.

TL;DR: Plasma levels of PMP, VEGF, IL-6 and RANTES were markedly increased in patients with stage IV disease, and it is demonstrated that these increased plasma levels of IL- 6, RantES, and especially PMP might be useful for identifying metastatic gastric patients.

TL;DR: In this article, the authors evaluated the antitumour response and time to progression (TTP) of patients treated with imatinib mesylate (Glivec®, Gleevec™, formerly STI-571) who had advanced and/or metastatic gastrointestinal stroma tumours (GIST) or other soft tissue sarcomas (STS).

TL;DR: The aim of this article was to provide guidelines for the routine clinical use of some of these markers, including carcinoembryonic antigen (CEA), for colorectal cancer detection and monitoring purposes.

TL;DR: The EORTC QLQ-OES18 demonstrates good psychometric and clinical validity and is recommended for use with the core questionnaire, the QL Q-C30, to assess QOL in patients with oesophageal cancer.

TL;DR: This study investigated whether preoperative axillary ultrasonography and fine-needle aspiration cytology can reduce the number of the more time-consuming SLNPs, and to identify a subset of quantitative nodal features to predict metastatic involvement.

TL;DR: The decline in ERbeta expression paralleled the loss of differentiation of malignant colon cells, regardless of the tumour's localisation, suggesting a protective role for ERbeta against colon carcinogenesis.

TL;DR: In a multivariate Cox regression analysis, diagnosis, treatment, age, physical complaints and workload remained the only significant predictors of duration of the sick leave.

TL;DR: It is suggested that the major determinants of the observed trends vary among the countries and may include earlier detection through screening in countries where this has been introduced, but also improvements in therapy, in countries with or without screening.

TL;DR: The epidermal growth factor receptor (EGFR) is a rational target for cancer therapy because it is commonly expressed at a high level in a variety of solid tumours and it has been implicated in the control of cell survival, proliferation, metastasis and angiogenesis.

TL;DR: Cilengitide can be safely administered using a continuous twice-weekly infusion regimen and should be explored at different doses, according to patients with histologically- or cytologically-confirmed metastatic solid tumours.

TL;DR: The difference in the time course of emesis blockade observed with two different classes of receptor antagonists provides substantial evidence for involvement of separate pathophysiological mechanisms in chemotherapy-induced vomiting.

TL;DR: An evaluation of the accuracy of SN biopsy as a staging procedure, the yields of different sectioning methods and the immunohistochemical detection of metastatic cells are reviewed and it is suggested that approximately 18% of the cases may be associated with further nodal (non-SN) metastases.

TL;DR: Improvements in the overall survival, quality of care and quality of survival of adolescents with cancer will only occur by surmounting the challenges unique to this group of patients, discussed in this review.

TL;DR: The purpose of this article is to review the current knowledge in terms of the epidemiology, biology, prognosis, management and outcome of patients with NPC.

TL;DR: It appears that age itself and the boost dose were the only factors that were independently related to local control that might explain the high local recurrence rate in the younger patients.

TL;DR: Young women who are at a potential high-risk of developing breast cancer such as those with germline mutations of BRCA1, BRCa2, TP53, PTEN or who have previously received mantle irradiation for Hodgkin's disease need close follow-up and are candidates for screening from a young age.

TL;DR: For example, this paper showed that letrozole (2.5 mg per day) was significantly more potent than anastrozoles (Arimidex) in inhibiting aromatase activity in vitro and inhibiting total body aromatisation in patients with breast cancer.

TL;DR: Results support the clinical and psychometric validity of the EORTC QLQ-OV28 module as a supplement to the E ORTC Q lQ-C30 and multi-trait scaling analyses confirmed the hypothesised scales.

TL;DR: Although no improvement in survival was observed, the favourable profile of anastrozole with respect to efficacy (TTP) and tolerability support the use of anastsrozoles in advance of tamoxifen as the first-line therapy choice in postmenopausal women with ABC.

TL;DR: Since systematic dose reduction can impact on outcome, primary prophylactic use of G-CSF for all elderly patients receiving curative myelotoxic chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) or CHOP-like) is indicated and a risk-adapted strategy with primary proPHylactic G- CSF administration in high-risk patients is suggested.

TL;DR: The management of older persons with cancer requires the acquisition of special skills in the evaluation of the older person and in the recognition and management of emergencies as well as experience in geriatric case management.

TL;DR: The data obtained from this non-randomised study do not support discontinuation and exchange of all drugs used preoperatively in histological poor responders, and female gender appears to be a strong predictor of a favourable outcome.

TL;DR: The hypothesised metastases model illustrates the importance of early detection, the concept of breast-conserving therapy and additional metastases from local recurrence, and highlights the benefits of optimal local therapy of the primary tumour and the limitations of systemic therapy.

TL;DR: Osteosarcoma in the elderly is a curable condition and warrants intensive treatment with chemotherapy and surgical resection and it is found that older patients had less chemotherapy and fared worse.

TL;DR: In this paper, the MAGE-3-positive measurable metastatic cancer, most of them with melanoma, were vaccinated with escalating doses of a recombinant MAGE3 protein combined with a fixed dose of the immunological adjuvant SBAS-2, which contained MPL and QS21.