Cancer stem cells and drug resistance: the potential of nanomedicine.
Serguei V. Vinogradov,Xin Wei +1 more
TLDR
This review is focused on tumor drug resistance-related properties of CSCs and describes current nanomedicine approaches, which could form the basis of novel combination therapies for eliminating metastatic and C SCs.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2012-04-04 and is currently open access. It has received 393 citations till now. The article focuses on the topics: Cancer stem cell & Drug delivery.read more
Citations
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Nanomedicine therapeutic approaches to overcome cancer drug resistance.
TL;DR: This review aims to demonstrate the advantage of the young medical science field, nanomedicine, for overcoming cancer drug resistance with the advanced design and alternative mechanisms of drug delivery known for different nanodrugs.
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MSN anti-cancer nanomedicines: chemotherapy enhancement, overcoming of drug resistance, and metastasis inhibition.
TL;DR: This review highlights the most recent advances of MSN anti‐cancer nanomedicines in enhancing chemotherapeutic efficacy, overcoming the MDR and inhibiting metastasis, and proposes several innovative and forward‐looking anti-cancer strategies.
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Plant-derived anticancer agents: A green anticancer approach
Javed Iqbal,Banzeer Ahsan Abbasi,Tariq Mahmood,Sobia Kanwal,Barkat Ali,Sayed Afzal Shah,Ali Talha Khalil,Ali Talha Khalil +7 more
TL;DR: Effort has been made through this comprehensive review to highlight the recent developments and milestones achieved in cancer therapies using phytomolecules with their mechanism of action on nuclear and cellular factors.
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Point of care testing: The impact of nanotechnology.
Leila Syedmoradi,Maryam S. Daneshpour,Mehrdad Alvandipour,Frank A. Gomez,Hassan Hajghassem,Kobra Omidfar +5 more
TL;DR: Present technologies in on-site or at home POC diagnostic assays implemented in paper-based microfluidic and screen printing devices over the past decade as well as in the near future are discussed.
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Role of integrated cancer nanomedicine in overcoming drug resistance
TL;DR: This review presents some of the important principles involved in development of MDR and novel methods of treating cancers using multifunctional-targeted nanoparticles.
References
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Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
Piyush Gupta,Piyush Gupta,Tamer T. Onder,Guozhi Jiang,Guozhi Jiang,Kai Tao,Charlotte Kuperwasser,Robert A. Weinberg,Eric S. Lander +8 more
TL;DR: Global gene expression analyses show that salinomycin treatment results in the loss of expression of breast CSC genes previously identified by analyses of breast tissues isolated directly from patients, demonstrating the ability to identify agents with specific toxicity for epithelial CSCs.
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The stem-cell niche as an entity of action
TL;DR: The interplay between stem cells and their niche creates the dynamic system necessary for sustaining tissues, and for the ultimate design of stem-cell therapeutics.
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Targeted drug delivery to tumors: myths, reality and possibility.
You Han Bae,Kinam Park +1 more
TL;DR: It would be profitable to address a variety of issues and factors that could affect the development of improved targeted drug delivery systems, including nanocarrier, nanovehicle, nanosystem, nanostructure, and other terms used in the literature.
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Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
Lucia Ricci-Vitiani,Roberto Pallini,Mauro Biffoni,Matilde Todaro,Gloria Invernici,Tonia Cenci,Giulio Maira,Eugenio Parati,Giorgio Stassi,Luigi Maria Larocca,Ruggero De Maria +10 more
TL;DR: A variable number (range 20–90%, mean 60.7%) of endothelial cells in glioblastoma carry the same genomic alteration as tumour cells, indicating that a significant portion of the vascular endothelium has a neoplastic origin.
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Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche
Cristina Grange,Marta Tapparo,Federica Collino,Loriana Vitillo,Christian Damasco,Maria Chiara Deregibus,Ciro Tetta,Benedetta Bussolati,Giovanni Camussi +8 more
TL;DR: This work reports that a subset of tumor-initiating cells expressing the mesenchymal stem cell marker CD105 in human renal cell carcinoma releases MVs that trigger angiogenesis and promote the formation of a premetastatic niche.