2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren's Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts
Caroline H. Shiboski,Stephen Shiboski,Raphaèle Seror,Lindsey A. Criswell,M. Labetoulle,Thomas M. Lietman,Astrid Rasmussen,Hal Scofield,Claudio Vitali,Simon J Bowman,Xavier Mariette +10 more
TLDR
To develop and validate an international set of classification criteria for primary Sjögren's syndrome using guidelines from the American College of Rheumatology and the European League Against Rheumatism.Abstract:
Objective
To develop and validate an international set of classification criteria for primary Sjogren's syndrome (SS) using guidelines from the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). These criteria were developed for use in individuals with signs and/or symptoms suggestive of SS.
Methods
We assigned preliminary importance weights to a consensus list of candidate criteria items, using multi-criteria decision analysis. We tested and adapted the resulting draft criteria using existing cohort data on primary SS cases and non-SS controls, with case/non-case status derived from expert clinical judgment. We then validated the performance of the classification criteria in a separate cohort of patients.
Results
The final classification criteria are based on the weighted sum of 5 items: anti-SSA/Ro antibody positivity and focal lymphocytic sialadenitis with a focus score of ≥1 foci/4 mm2, each scoring 3; an abnormal ocular staining score of ≥5 (or van Bijsterveld score of ≥4), a Schirmer's test result of ≤5 mm/5 minutes, and an unstimulated salivary flow rate of ≤0.1 ml/minute, each scoring 1. Individuals with signs and/or symptoms suggestive of SS who have a total score of ≥4 for the above items meet the criteria for primary SS. Sensitivity and specificity against clinician-expert–derived case/non-case status in the final validation cohort were high, i.e., 96% (95% confidence interval [95% CI] 92–98%) and 95% (95% CI 92–97%), respectively.
Conclusion
Using methodology consistent with other recent ACR/EULAR-approved classification criteria, we developed a single set of data-driven consensus classification criteria for primary SS, which performed well in validation analyses and are well-suited as criteria for enrollment in clinical trials.read more
Citations
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Safety and efficacy of anti-programmed death 1 antibodies in patients with cancer and pre-existing autoimmune or inflammatory disease.
François-Xavier Danlos,Anne-Laure Voisin,Valérie Dyevre,Jean-Marie Michot,Emilie Routier,Laurent Taillade,Stéphane Champiat,Sandrine Aspeslagh,Julien Haroche,Laurence Albiges,Christophe Massard,Nicolas Girard,Stéphane Dalle,Benjamin Besse,Salim Laghouati,Jean-Charles Soria,Christine Mateus,Caroline Robert,Emilie Lanoy,Aurélien Marabelle,Olivier Lambotte +20 more
TL;DR: In patients treated with anti-PD-1 antibody, pre-existing AID was associated with a significantly increased risk of irAEs, and results indicate that cancer treatments withAnti- PD-1 antibodies are just as effective in AID patients as they are in AIDs-free patients.
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Severe intestinal dysbiosis is prevalent in primary Sjögren’s syndrome and is associated with systemic disease activity
TL;DR: Severe intestinal dysbiosis is a prevalent finding in primary Sjögren’s syndrome and is associated both with clinical and laboratory markers of systemic disease activity as well as gastrointestinal inflammation.
Journal ArticleDOI
Video clip assessment of a salivary gland ultrasound scoring system in Sjögren’s syndrome using consensual definitions: an OMERACT ultrasound working group reliability exercise
Sandrine Jousse-Joulin,Maria Antonietta D'Agostino,Céline Nicolas,Esperanza Naredo,Sarah Ohrndorf,Marina Backhaus,Giorgio Tamborrini,Isabelle Chary-Valckenaere,Lene Terslev,Annamaria Iagnocco,Paz Collado,Cristina Hernández-Díaz,Frédérique Gandjbakhch,Wolfgang A. Schmidt,Georgios Filippou,Christian Dejaco,Martin H Stradner,Mohamed Mortada,Alojzija Hočevar,Stavros Chrysidis,Ghada El Mardenly,Juan José de Agustín,Ralf G. Thiele,Daryl K. MacCarter,Stephanie Finzel,Petra Hanova,Alen Zabotti,Cornelia Glaser,Zarrin Alavi,Daniel Hammenfors,Florence Gatineau,George A W Bruyn +31 more
TL;DR: In this paper, the authors developed and tested new definitions for developing a novel semiquantitative US score in patients with Sjogren's syndrome (pSS) on video clips.
Journal ArticleDOI
Clinical and immunological parameters of Sjögren's syndrome
Konstantia Psianou,Ioannis Panagoulias,Anastasios D. Papanastasiou,Anne-Lise de Lastic,Maria Rodi,Panagiota I. Spantidea,Søren E. Degn,Panagiotis Georgiou,Athanasia Mouzaki +8 more
TL;DR: A comprehensive update on SS is presented with emphasis on immune system involvement, and new insights into SS immunopathogenesis are suggested.
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Moving towards a molecular taxonomy of autoimmune rheumatic diseases
Guillermo Barturen,Lorenzo Beretta,Ricard Cervera,Ronald F van Vollenhoven,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme +5 more
TL;DR: The basis for a new molecular taxonomy for autoimmune rheumatic diseases is discussed, the evidence surrounding the idea that these diseases share molecular features related to their pathogenesis and development and previous attempts to classify these diseases are highlighted.
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Conditional variable importance for random forests
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