6-month consequences of COVID-19 in patients discharged from hospital: a cohort study.
Chaolin Huang,Lixue Huang,Lixue Huang,Yeming Wang,Xia Li,Lili Ren,Xiaoying Gu,Xiaoying Gu,Liang Kang,Lili Guo,Min Liu,Xing Zhou,Jianfeng Luo,Zhenghui Huang,Shengjin Tu,Yue Zhao,Li Chen,Decui Xu,Yanping Li,Caihong Li,Lu Peng,Yong Mei Li,Wuxiang Xie,Dan Cui,Dan Cui,Lianhan Shang,Lianhan Shang,Guohui Fan,Guohui Fan,Jiuyang Xu,Geng Wang,Geng Wang,Ying Wang,Jingchuan Zhong,Chen Wang,Chen Wang,Jianwei Wang,Dingyu Zhang,Bin Cao +38 more
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TLDR
In this article, the authors describe the long-term health consequences of patients with COVID-19 who have been discharged from hospital and investigate the associated risk factors, in particular disease severity.About:
This article is published in The Lancet.The article was published on 2021-01-16 and is currently open access. It has received 2933 citations till now. The article focuses on the topics: Pulmonary diffusion & Severity of illness.read more
Citations
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Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages
Sina Bohnacker,Franziska Hartung,Fiona Henkel,Alessandro Quaranta,Johan Kolmert,Alina Priller,Minhaz Ud-Dean,Johanna Giglberger,Luisa M. Kugler,Lisa Pechtold,Sarah Yazici,Anton Lechner,Johanna Erber,Ulrike Protzer,Paul Lingor,Percy A. Knolle,Adam Chaker,Carsten B. Schmidt-Weber,Craig E. Wheelock,Julia Esser-von Bieren +19 more
TL;DR: SARS-CoV-2 infection leaves an inflammatory imprint in the monocyte/macrophage compartment that drives aberrant macrophage effector functions and eicosanoid metabolism, resulting in long-term immune aberrations in patients recovering from mild COVID-19.
Journal ArticleDOI
Long-COVID Headache.
TL;DR: The so-called long COVID-19 is a set of symptoms that accompanies the patient even for months after discharge from the hospital as discussed by the authors, and the symptoms include easy muscle fatigue, moderate breathlessness, persistent headache, the feeling of a foggy head and the development of psychiatric disorders.
Journal ArticleDOI
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice
Kenneth H. Dinnon,Sarah R. Leist,Kenichi Okuda,Hong Dang,Ethan J. Fritch,Kendra Gully,Gabriela De la Cruz,M. Evangelista,Takanori Asakura,Rodney C. Gilmore,Padraig E Hawkins,Satoko Nakano,Ande West,Alexandra Schäfer,Lisa E. Gralinski,Jamie L. Everman,Satria Sajuthi,M. Zweigart,Stephanie Dong,Jennifer McBride,Michelle R. Cooley,Jesse B. Hines,M. K. Love,Steve D. Groshong,A. VanSchoiack,Stefan J. Phelan,Yan Liang,Tyler Hether,Michael Leon,Ross E. Zumwalt,Lisa M. Barton,Eric J. Duval,Sanjay Mukhopadhyay,Edana Stroberg,Alain C. Borczuk,Leigh B. Thorne,Muthu Kumar Sakthivel,Yueh Z. Lee,James S. Hagood,Jason R. Mock,Max A. Seibold,Wanda K. O'Neal,Stephanie A. Montgomery,Richard C. Boucher,Ralph S. Baric +44 more
TL;DR: The mouse-adapted severe acute respiratory syndrome coronavirus 2 strain MA10 produces an acute respiratory distress syndrome in mice similar to humans, and this murine model provides opportunities to identify pathways associated with persistent SARS-CoV-2 pulmonary disease and test countermeasures to ameliorate PASC.
Journal ArticleDOI
Long COVID-19 and Postural Orthostatic Tachycardia Syndrome- Is Dysautonomia to Be Blamed?
TL;DR: It is important to educate healthcare professionals to recognise complications and conditions arising from COVID-19, such as POTS, to allow prompt diagnosis and access to early treatment, and to elucidate the underlying mechanisms of dysautonomia to enable the development of targeted therapies.
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Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study.
Lovisa Hellgren,Ulrika Birberg Thornberg,Kersti Samuelsson,Richard Levi,Anestis Divanoglou,Ida Blystad +5 more
TL;DR: In this paper, the authors report findings on brain MRI and neurocognitive function, as well as persisting fatigue at long-term follow-up after COVID-19 hospitalisation in patients identified as high risk for affection of the central nervous system.
References
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A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.
Bin Cao,Yeming Wang,Danning Wen,Wen Liu,Jingli Wang,Guohui Fan,Lianguo Ruan,Bin Song,Yanping Cai,Ming Wei,Xingwang Li,Jia'an Xia,Nanshan Chen,Jie Xiang,Ting Yu,Tao Bai,Xuelei Xie,Li Zhang,Caihong Li,Ye Yuan,Hua Chen,Huadong Li,Hanping Huang,Shengjing Tu,Fengyun Gong,Ying Liu,Yuan Wei,Chongya Dong,Fei Zhou,Xiaoying Gu,Jiuyang Xu,Zhibo Liu,Yi Zhang,Li Hui,Lianhan Shang,Ke Wang,Kunxia Li,Xia Zhou,Xuan Dong,Zhaohui Qu,Sixia Lu,Xujuan Hu,Shunan Ruan,Shanshan Luo,Jing Wu,Lu Peng,Fang Cheng,Lihong Pan,Jun Zou,Chunmin Jia,Juan Wang,Xia Liu,Shuzhen Wang,Xudong Wu,Qin Ge,Jing He,Haiyan Zhan,Fang Qiu,Li Guo,Chaolin Huang,Thomas Jaki,Frederick G. Hayden,Peter Horby,Dingyu Zhang,Chen Wang +64 more
TL;DR: In hospitalized adult patients with severe Covid-19, no benefit was observed with lopinavir–ritonavir treatment beyond standard care, and future trials in patients withsevere illness may help to confirm or exclude the possibility of a treatment benefit.
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