A CBP Binding Transcriptional Repressor Produced by the PS1/ϵ-Cleavage of N-Cadherin Is Inhibited by PS1 FAD Mutations
Philippe Marambaud,Paul H. Wen,Anindita Dutt,Junichi Shioi,Akihiko Takashima,Robert Siman,Nikolaos K. Robakis +6 more
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TLDR
It is shown that a PS1-dependent gamma-secretase protease activity promotes an epsilon-like cleavage of N-cadherin to produce its intracellular domain peptide, N-Cad/CTF2, which functions as a potent repressor of CBP/CREB-mediated transcription.About:
This article is published in Cell.The article was published on 2003-09-05 and is currently open access. It has received 461 citations till now. The article focuses on the topics: Repressor & Transcription factor.read more
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Convergence of Wnt, ß-Catenin, and Cadherin Pathways
W. James Nelson,Roel Nusse +1 more
TL;DR: Evidence is assembled of possible interrelations between Wnt and other growth factor signaling, β-catenin functions, and cadherin-mediated adhesion in tissue differentiation.
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EMT, the cytoskeleton, and cancer cell invasion
TL;DR: This review has summarized recent novel insights into the molecular processes and players underlying EMT on one side and the formation of invasive membrane protrusions on the other side.
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The cell-cell adhesion molecule E-cadherin
F. Van Roy,Geert Berx +1 more
TL;DR: The multiple mechanisms that disrupt E-cadherin function in cancer are reviewed: inactivating somatic and germline mutations, epigenetic silencing by DNA methylation and epithelial to mesenchymal transition-inducing transcription factors, and dysregulated protein processing.
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The ADAM metalloproteinases.
TL;DR: The ADAM family are fundamental to many control processes in development and homeostasis, and unsurprisingly they are also linked to pathological states when their functions are dysregulated, including cancer, cardiovascular disease, asthma, Alzheimer’s disease.
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Cadherins in development: cell adhesion, sorting, and tissue morphogenesis
TL;DR: How different members of the cadherin family act in different developmental contexts is examined, and the mechanisms involved are discussed.
References
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TL;DR: Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators, whereas JunB has the converse effect.
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Transcriptional regulation by the phosphorylation-dependent factor CREB
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TL;DR: The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?
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