Journal ArticleDOI
A leading role for the immune system in the pathophysiology of preeclampsia
TLDR
The pathophysiology of preeclampsia may involve several factors, including persistent hypoxia at the placental level and the release of high amounts of STBMs, which may contribute to the inflammatory process and to changes in adaptive‐immune system cells, which are also modulated in preeclamping.Abstract:
Preeclampsia syndrome is characterized by inadequate placentation, because of deficient trophoblastic invasion of the uterine spiral arteries, leading to placental hypoxia, secretion of proinflammatory cytokines, the release of angiogenic and antiangiogenic factors and miRNAs. Although immune-system alterations are associated with the origin of preeclampsia, other factors, including proinflammatory cytokines, neutrophil activation, and endothelial dysfunction, are also related to the pathophysiology of this syndrome. The pathophysiology of preeclampsia may involve several factors, including persistent hypoxia at the placental level and the release of high amounts of STBMs. DAMP molecules released under hypoxic conditions and STBMs, which bind TLRs, may activate monocytes, DCs, NK cells, and neutrophils, promoting persistent inflammatory conditions in this syndrome. The development of hypertension in preeclamptic women is also associated with endothelial dysfunction, which may be mediated by various mechanisms, including neutrophil activation and NET formation. Furthermore, preeclamptic women have higher levels of nonclassic and intermediate monocytes and lower levels of lymphoid BDCA-2(+) DCs. The cytokines secreted by these cells may contribute to the inflammatory process and to changes in adaptive-immune system cells, which are also modulated in preeclampsia. The changes in T cell subsets that may be seen in preeclampsia include low Treg activity, a shift toward Th1 responses, and the presence of Th17 lymphocytes. B cells can participate in the pathophysiology of preeclampsia by producing autoantibodies against adrenoreceptors and autoantibodies that bind the AT1-R.read more
Citations
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Journal ArticleDOI
Association between maternal serum 25-hydroxyvitamin D concentrations and the risk of pre-eclampsia in central Sudan: a case-control study.
TL;DR: In this article, the authors investigated the association between 25-hydroxyvitamin D (25[OH)]D) levels and pre-eclampsia and found that low 25-OHD levels were an independent risk factor for pre-ECLampsia.
Journal ArticleDOI
Excessive Immune Activation and the Correlation with Decreased Expression of PD-1 at the Maternal–Fetal Interface in Preeclampsia
TL;DR: The data suggested that the inflammatory pattern and decreased PD-1 expression in the decidua might play an active role in the local immunoregulatory mechanisms of PE.
Posted ContentDOI
A Transcriptome Fingerprinting Assay for Clinical Immune Monitoring
Matthew C. Altman,Matthew C. Altman,Nicole Baldwin,Elizabeth Whalen,Al-Shaikhly T,S. Presnell,Prasong Khaenam,Vivian H. Gersuk,Laurent Chiche,Noémie Jourde-Chiche,J. T. Phillips,Goran B. Klintmalm,Anne O'Garra,Anne O'Garra,Matthew Berry,Chloe I Bloom,Robert J. Wilkinson,Robert J. Wilkinson,Robert J. Wilkinson,Christine M. Graham,Marc Lipman,Ganjana Lertmemongkolchai,Farrah Kheradmand,Asuncion Mejias,Octavio Ramilo,Karolina Palucka,Pascual,Pascual,Jacques Banchereau,Damien Chaussabel +29 more
TL;DR: This work demonstrates the utility of data-driven network analysis applied to large-scale transcriptional profiling to identify key markers of immune responses, which can be downscaled to a rapid, inexpensive, and highly versatile assay of global immune function applicable to diverse investigations of immunopathogenesis and biomarker discovery.
Journal ArticleDOI
Evaluation of Transforming Growth Factor-β1 and Interleukin-35 Serum Levels in Patients with Placenta Accreta.
Tayyebe Khamoushi,Moslem Ahmadi,Mohammad Ali-Hassanzadeh,Mohammad Ali-Hassanzadeh,Maryam Zare,Fateme Hesampour,Behrouz Gharesi-Fard,Sedigheh Amooee +7 more
TL;DR: The serum levels of IL-35 and TGF-β1 may contribute to the pathogenesis of placenta accreta and could be considered as potential targets in clinical and diagnostic approaches.
Journal ArticleDOI
Uncaria tomentosa extract (AC-11) improves pregnancy hypertension together with suppression of sFlt-1 and sEng.
Yuka Oogaki,Ren Ozawa,Kai Seshima,Riina Shinoda,Yasushi Torii,Hironori Takahashi,Hisataka Iwata,Takehito Kuwayama,Koumei Shirasuna +8 more
TL;DR: In this article, the authors investigated whether AC-11 has a protective effect on pathogenesis of hypertensive disorders of pregnancy in vivo and production of anti-angiogenic factors (sFlt-1 and sEng, major factors for the onset of HDP) in in vitro.
References
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Journal ArticleDOI
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