Journal ArticleDOI
A radiation-induced adaptive response prolongs the survival of prion-infected mice.
Margot Plews,Sharon L.R. Simon,Douglas R. Boreham,Debra Parchaliuk,Heather Wyatt,Rebecca Mantha,Kathy L. Frost,Lise Lamoureux,Michael Stobart,Michael Stobart,Stefanie Czub,R. E. J. Mitchel,J. David Knox,J. David Knox +13 more
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TLDR
Exposure of prion-infected mice to four 500 mGy/fraction doses of (60)Co γ-radiation administered every other day at a low dose rate significantly prolonged the survival of infected mice, and the duration of the reduction in oxidative stress achieved by the radiation treatments was similar in length to the prolonged survival of the irradiated mice.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2010-11-15. It has received 18 citations till now. The article focuses on the topics: Oxidative stress.read more
Citations
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Journal ArticleDOI
The neglected significance of "antioxidative stress".
Borut Poljšak,Irina Milisav +1 more
TL;DR: Increasing evidence is synthesized on “antioxidative stress-induced” beneficial versus harmful roles on health, disease, and aging processes and on the potential harmful effects of synthetic antioxidants.
Journal ArticleDOI
Non-linear adaptive phenomena which decrease the risk of infection after pre-exposure to radiofrequency radiation
Seyed Mohammad Javad Mortazavi,Mohammad Motamedifar,G. Namdari,Mohammad Taheri,A.R. Mortazavi,Nasrin Shokrpour +5 more
TL;DR: The findings contribute to the assumption that radiofrequency-induced adaptive response can be used as an efficient method for decreasing the risk of infection in immunosuppressed irradiated individuals.
Journal ArticleDOI
Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization.
Franco Cortese,Dmitry Klokov,Dmitry Klokov,Andreyan N. Osipov,Andreyan N. Osipov,Jakub Stefaniak,Alexey Moskalev,Alexey Moskalev,Alexey Moskalev,Jane Schastnaya,Charles R. Cantor,Alexander Aliper,Polina Mamoshina,Polina Mamoshina,Igor Ushakov,Alex Sapetsky,Quentin Vanhaelen,Irina Alchinova,Mikhail Karganov,Olga Kovalchuk,Ruth C. Wilkins,A. S. Shtemberg,Marjan Moreels,Sarah Baatout,Evgeny Izumchenko,Evgeny Izumchenko,João Pedro de Magalhães,Artem V. Artemov,Sylvain V. Costes,Afshin Beheshti,Afshin Beheshti,Xiao Wen Mao,Michael J. Pecaut,Dmitry Kaminskiy,Ivan V. Ozerov,Morten Scheibye-Knudsen,Alex Zhavoronkov +36 more
TL;DR: This work lays the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration, and articulates the position that enhancing human radoresistance is likely to extend the healthspan of human spacefarers as well.
Journal ArticleDOI
Re-evaluation of the linear no-threshold (LNT) model using new paradigms and modern molecular studies.
TL;DR: The evidence presented in this review reveals that there are minimal health risks with LDR exposure, and that a dose higher than some threshold value is necessary to achieve the harmful effects classically observed with high doses of radiation.
Journal ArticleDOI
Acute exposure to prion infection induces transient oxidative stress progressing to be cumulatively deleterious with chronic propagation in vitro
Cathryn L. Haigh,Amelia McGlade,Victoria Lewis,Colin L. Masters,Victoria A. Lawson,Steven J. Collins +5 more
TL;DR: Using cell culture models of prion infection, it is found that cells demonstrate a rapid, prion protein (PrP) dependent, increase in intracellular ROS following exposure to infectious inoculum, which strengthens the direct links between heightened ROS and ongoing prion propagation with eventual cellular demise.
References
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Journal ArticleDOI
Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics.
TL;DR: Using the ELISA developed, it is found that the normal range of urinary 8-OHdG for females was 43.9 +/- 42.1 ng/mg creatinine and 29.6 +/- 24.5 ng/ mg creatinines for males, respectively, while the normal value between females and males is significantly different (p < 0.001).
Journal ArticleDOI
Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology.
TL;DR: Evidence supporting the concept that perturbations in intracellular metabolic oxidation/reduction reactions contribute to the biological effects of radiation exposure is focused on as well as new concepts emerging from the field of free radical biology that may be relevant to future studies in radiobiology.
Journal ArticleDOI
Toxicology rethinks its central belief
TL;DR: Hormesis demands a reappraisal of the way risks are assessed for the first time in 25 years.
Journal ArticleDOI
Evidence for beneficial low level radiation effects and radiation hormesis.
TL;DR: The linear-no-threshold (LNT) hypothesis for cancer risk is scientifically unfounded and appears to be invalid in favour of a threshold or hormesis, consistent with data both from animal studies and human epidemiological observations on low-dose induced cancer.
Book ChapterDOI
Oxidative stress and the pathogenesis of neurodegenerative disorders.
TL;DR: The need for novel therapeutic strategies that attenuate neuroinflammation and protect neurons against oxidative stress is ever more immediate because the prevalence and incidence of age-related neurodegenerative diseases are on the rise.
Related Papers (5)
The Effects of Pretreatment with X-Rays on the Pathogenesis of Lymphocytic Choriomeningitis in Mice: I. Host Survival, Virus Multiplication and Leukocytosis
John Hotchin,Heribert Weigand +1 more