A retinoid-related molecule that does not bind to classical retinoid receptors potently induces apoptosis in human prostate cancer cells through rapid caspase activation.
Richard G. Keedwell,Yi Zhao,Lisette A. Hammond,Suofu Qin,Kwok-Yin Tsang,Armin Reitmair,Yanira Molina,Yumiko Okawa,Larissa I. Atangan,Dixie-Lee Shurland,Kaisheng Wen,D. Michael A. Wallace,Roger Bird,Roshantha A.S. Chandraratna,Geoffrey Brown +14 more
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Findings show that caspase-mediated induction of apoptosis by AGN193198 is RAR/RXR-independent and suggest that this compound may be useful in the treatment of prostate cancer.Citations
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Mitochondrial Membrane Permeabilization in Cell Death
TL;DR: Once MMP has been induced, it causes the release of catabolic hydrolases and activators of such enzymes (including those of caspases) from mitochondria, meaning that mitochondria coordinate the late stage of cellular demise.
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RAR and RXR modulation in cancer and metabolic disease
TL;DR: The challenges and opportunities for therapeutic strategies based on RXR and RAR modulators, with a focus on cancer and metabolic diseases such as diabetes and obesity, are discussed.
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13-cis Retinoic Acid Induces Apoptosis and Cell Cycle Arrest in Human SEB-1 Sebocytes
TL;DR: It is indicated that 13-cis RA causes cell cycle arrest and induces apoptosis in SEB-1 sebocytes by a RAR-independent mechanism, which contributes to its sebosuppressive effect and the resolution of acne.
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PI3K/AKT and ERK regulate retinoic acid-induced neuroblastoma cellular differentiation.
TL;DR: It is found that the PI3K/AKT pathway is required for RA-induced Neuroblastoma cell differentiation, which may be important for developing novel therapeutic strategy against poorly differentiated neuroblastoma.
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Inhibition of IκB Kinase-β and Anticancer Activities of Novel Chalcone Adamantyl Arotinoids
Paula Lorenzo,Rosana Alvarez,Maria A. Ortiz,Susana Alvarez,F. Javier Piedrafita,Angel R. de Lera +5 more
TL;DR: A new series of AdArs structurally related to chalcone 7 have been designed and synthesized, intended to reduce or eliminate RAR activity, and the effect of the novel analogues of 7 on IKKbeta activity and proliferation of a variety of cancer cell lines is evaluated.
References
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Cancer statistics, 1998
TL;DR: The Surveillance Research Program of the American Cancer Society's Department of Epidemiology and Surveillance reports its 32nd annual compilation of cancer incidence, mortality, and survival data for the United States and around the world.
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JC‐1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis
TL;DR: Data indicate that JC‐1 is a reliable probe for analyzing ΔΨ changes with flow cytometry, while the others show a lower sensitivity (R123), or a non‐coherent behaviour, due to a high sensitivity to changes in plasmamembrane potential [DiOC6(3].
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Suicidal tendencies: apoptotic cell death by caspase family proteinases.
Beni B. Wolf,Douglas R. Green +1 more
TL;DR: This work reviews caspase proteinases with an emphasis on their structure, activation, and critical role in the apoptotic mechanism.
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The promise of retinoids to fight against cancer
TL;DR: Understanding of the mechanisms that underlie the anti-proliferative action of retinoids will help to exploit the beneficial aspects of this powerful class of compounds for cancer therapy and prevention.
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A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
David J. Mangelsdorf,David J. Mangelsdorf,Kazuhiko Umesono,Kazuhiko Umesono,Steven A. Kliewer,Uwe Borgmeyer,Estelita S. Ong,Estelita S. Ong,Ronald M. Evans,Ronald M. Evans +9 more
TL;DR: Evidence is provided that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR, suggesting that an RXR-mediated pathway exists for modulating vitamin A metabolism.