Journal ArticleDOI
A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact
Siri Beier Jensen,Anne Marie Lynge Pedersen,Arjan Vissink,Elo Andersen,Carlton G. Brown,Andrew Davies,J. Dutilh,Janet S. Fulton,Ljiljana Janković,Nilza Nelly Fontana Lopes,A. L. S. Mello,L. V. Muniz,C. A. Murdoch-Kinch,Raj G. Nair,Joel J. Napeñas,A. Nogueira-Rodrigues,Deborah P. Saunders,B. Stirling,I. von Bültzingslöwen,Dianna Weikel,Linda S. Elting,Fred K. L. Spijkervet,Michael T. Brennan,Salivary Gland Hypofunction,Xerostomia Section +24 more
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TLDR
There is evidence that salivary gland hypofunction and xerostomia induced by cancer therapies can be prevented or symptoms be minimized to some degree, depending on the type of cancer treatment.Abstract:
This systematic review aimed to assess the literature for management strategies and economic impact of salivary gland hypofunction and xerostomia induced by cancer therapies and to determine the quality of evidence-based management recommendations. The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. For each article, two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results, and conclusions. Seventy-two interventional studies met the inclusion criteria. In addition, 49 intensity-modulated radiation therapy (IMRT) studies were included as a management strategy aiming for less salivary gland damage. Management guideline recommendations were drawn up for IMRT, amifostine, muscarinic agonist stimulation, oral mucosal lubricants, acupuncture, and submandibular gland transfer. There is evidence that salivary gland hypofunction and xerostomia induced by cancer therapies can be prevented or symptoms be minimized to some degree, depending on the type of cancer treatment. Management guideline recommendations are provided for IMRT, amifostine, muscarinic agonist stimulation, oral mucosal lubricants, acupuncture, and submandibular gland transfer. Fields of sparse literature identified included effects of gustatory and masticatory stimulation, specific oral mucosal lubricant formulas, submandibular gland transfer, acupuncture, hyperbaric oxygen treatment, management strategies in pediatric cancer populations, and the economic consequences of salivary gland hypofunction and xerostomia.read more
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Journal ArticleDOI
Intraoral electrostimulator for xerostomia relief: a long-term, multicenter, open-label, uncontrolled, clinical trial
Iva Alajbeg,Denise Pinheiro Falcão,Simon D. Tran,Rafael Martín-Granizo,Gloria Inés Lafaurie,Domenica Matranga,Slavica Pejda,Lea Vuletić,Rubén D. Mantilla,Soraya Coelho Leal,Ana Cristina Barreto Bezerra,Henri A Ménard,Suguru Kimoto,Shaoxia Pan,L. Maniegas,Cheryl A. Krushinski,Dario Melilli,Giuseppina Campisi,Carlo Paderni,Gloria Rocío Bautista Mendoza,Juan F. Yepes,Liselott Lindh,Meltem Koray,Gonca Mumcu,Sharon Elad,Itai Zeevi,Beatriz Catalina Aldape Barrios,Rodrigo M. López Sánchez,Claire Lassauzay,Olivier Fromentin,Ben Z. Beiski,Frank Peter Strietzel,Yrjö T. Konttinen,Andy Wolff,Susan L. Zunt +34 more
TL;DR: Improvements achieved at month 5 from baseline were sustained throughout the follow-up period for the primary outcome, xerostomia severity, and the secondary outcomes resting whole salivary flow rate, xanaxia frequency, oral discomfort, and difficulties in speech, swallowing, and sleeping.
BookDOI
Oral Mucosal Drug Delivery and Therapy
TL;DR: This volume provides a comprehensive overview of the current issues facing scientists working on delivering drugs locally and systemically via the membranes that line the mouth, and provides insights into the in vitro and in vivo methods available to assess drug permeability and retention.
Journal ArticleDOI
Salivary gland transfer to prevent radiation-induced xerostomia: A systematic review and meta-analysis
Amit J. Sood,Nyssa F. Fox,Brendan P. O'Connell,Tiffany L. Lovelace,Shaun A. Nguyen,Anand K. Sharma,Joshua D. Hornig,Terry A. Day +7 more
TL;DR: Salivary gland transfer appears to be highly effective in preventing the incidence of xerostomia in patients receiving definitive head and neck radiation therapy, and change from baseline of unstimulated and stimulated salivary flow rates after XRT.
Journal ArticleDOI
Adult stem cells and tissue engineering strategies for salivary gland regeneration: a review
TL;DR: Current bioengineering approaches for salivary gland tissue engineering and the adult stem cell sources used for this purpose are highlighted and future considerations in regard to Salivary glands tissue engineering strategies are discussed.
Journal ArticleDOI
Regenerating Salivary Glands in the Microenvironment of Induced Pluripotent Stem Cells
TL;DR: The initial attempt to regenerate salivary glands using induced pluripotent stem (iPS) cells in vivo and in vitro suggests that iPS cells have a potential ability to accelerate differentiation forSalivary gland development and regeneration.
References
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Journal ArticleDOI
Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer
TL;DR: Dose/volume/function relationships in the parotid glands are characterized by dose and volume thresholds, steep dose/response relationships when the thresholds are reached, and a maximal volume dependence parameter in the NTCP model.
Journal ArticleDOI
Phase III Randomized Trial of Amifostine as a Radioprotector in Head and Neck Cancer
David M. Brizel,Todd H. Wasserman,Michael Henke,Vratislav Strnad,Volkar Rudat,Alain Monnier,François Eschwege,Jay Zhang,Lesley Russell,Wolfgang Oster,Rolf Sauer +10 more
TL;DR: With and without amifostine, 2-year local-regional control, disease-free survival, and overall survival were 58% versus 63, 53% versus 57%, and 71% versus 66%, respectively, while Antitumor treatment efficacy was preserved.
Journal ArticleDOI
Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer
Avraham Eisbruch,Hyungjin Myra Kim,Jeffrey E. Terrell,Jeffrey E. Terrell,Lon H. Marsh,Laura A. Dawson,Jonathan A. Ship +6 more
TL;DR: An improvement over time in xerostomia, occurring in tandem with rising salivary production from the spared major Salivary glands, suggests a long-term clinical benefit from their sparing.
Journal ArticleDOI
Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial.
Edmond H.N. Pow,Dora L.W. Kwong,Anne S. McMillan,May C. M. Wong,Jonathan S.T. Sham,Lucullus H.T. Leung,W. Keung Leung +6 more
TL;DR: IMRT was significantly better than CRT in terms of parotid sparing and improved QoL for early-stage disease and support the case for assessment of health-relatedQoL in relation to head-and-neck cancer using a site-specific approach.
Journal ArticleDOI
Prospective Randomized Study of Intensity-Modulated Radiotherapy on Salivary Gland Function in Early-Stage Nasopharyngeal Carcinoma Patients
Michael K.M. Kam,Sing Fai Leung,Benny Zee,Ricky M. C. Chau,Joyce J. S. Suen,Frankie Mo,Maria Lai,Rosalie Ho,Kin Yin Cheung,Brian K.H. Yu,Samuel K.W. Chiu,Peter H.K. Choi,Peter M.L. Teo,Wing Hong Kwan,Anthony T.C. Chan +14 more
TL;DR: IMRT is superior to 2DRT in preserving parotid function and results in less severe delayed xerostomia in the treatment of early-stage NPC, which reflects the need to enhance protection of other salivary glands.
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