Journal ArticleDOI
A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact
Siri Beier Jensen,Anne Marie Lynge Pedersen,Arjan Vissink,Elo Andersen,Carlton G. Brown,Andrew Davies,J. Dutilh,Janet S. Fulton,Ljiljana Janković,Nilza Nelly Fontana Lopes,A. L. S. Mello,L. V. Muniz,C. A. Murdoch-Kinch,Raj G. Nair,Joel J. Napeñas,A. Nogueira-Rodrigues,Deborah P. Saunders,B. Stirling,I. von Bültzingslöwen,Dianna Weikel,Linda S. Elting,Fred K. L. Spijkervet,Michael T. Brennan,Salivary Gland Hypofunction,Xerostomia Section +24 more
Reads0
Chats0
TLDR
There is evidence that salivary gland hypofunction and xerostomia induced by cancer therapies can be prevented or symptoms be minimized to some degree, depending on the type of cancer treatment.Abstract:
This systematic review aimed to assess the literature for management strategies and economic impact of salivary gland hypofunction and xerostomia induced by cancer therapies and to determine the quality of evidence-based management recommendations. The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. For each article, two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results, and conclusions. Seventy-two interventional studies met the inclusion criteria. In addition, 49 intensity-modulated radiation therapy (IMRT) studies were included as a management strategy aiming for less salivary gland damage. Management guideline recommendations were drawn up for IMRT, amifostine, muscarinic agonist stimulation, oral mucosal lubricants, acupuncture, and submandibular gland transfer. There is evidence that salivary gland hypofunction and xerostomia induced by cancer therapies can be prevented or symptoms be minimized to some degree, depending on the type of cancer treatment. Management guideline recommendations are provided for IMRT, amifostine, muscarinic agonist stimulation, oral mucosal lubricants, acupuncture, and submandibular gland transfer. Fields of sparse literature identified included effects of gustatory and masticatory stimulation, specific oral mucosal lubricant formulas, submandibular gland transfer, acupuncture, hyperbaric oxygen treatment, management strategies in pediatric cancer populations, and the economic consequences of salivary gland hypofunction and xerostomia.read more
Citations
More filters
Journal ArticleDOI
A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life
Siri Beier Jensen,Anne Marie Lynge Pedersen,Arjan Vissink,Elo Andersen,C. G. Brown,Andrew Davies,J. Dutilh,Janet S. Fulton,Ljiljana Janković,Nilza Nelly Fontana Lopes,A. L. S. Mello,L. V. Muniz,C. A. Murdoch-Kinch,Raj G. Nair,Joel J. Napeñas,A. Nogueira-Rodrigues,Deborah P. Saunders,B. Stirling,I. von Bültzingslöwen,Dianna Weikel,Linda S. Elting,Frederik Spijkervet,Michael T. Brennan +22 more
TL;DR: Salivary gland hypofunction and xerostomia are induced by radiotherapy in the head and neck region depending on the cumulative radiation dose to the gland tissue, and treatment focus should be on optimized/new approaches to further reduce the doses to the parotids.
Journal ArticleDOI
Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers
Arjan Vissink,James B. Mitchell,Bruce J. Baum,Kirsten H. Limesand,Siri Beier Jensen,Philip C. Fox,Linda S. Elting,Johannes A. Langendijk,Robert P. Coppes,Mary E. Reyland +9 more
TL;DR: This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivARY gland hypofunction and xerostomia.
Journal ArticleDOI
Interventions for the management of dry mouth: topical therapies.
TL;DR: There is no strong evidence from this review that any topical therapy is effective for relieving the symptom of dry mouth, and both integrated mouthcare systems and oral reservoir devices show promising results but there is insufficient evidence at present to recommend their use.
Journal ArticleDOI
Medication-Related Osteonecrosis of the Jaw: MASCC/ISOO/ASCO Clinical Practice Guideline
Noam Yarom,Noam Yarom,Charles L. Shapiro,Douglas E. Peterson,Catherine Van Poznak,Kari Bohlke,Salvatore L. Ruggiero,Salvatore L. Ruggiero,Cesar A. Migliorati,Aliya Khan,Archie Morrison,Archie Morrison,Holly Anderson,Barbara A. Murphy,Devena E. Alston-Johnson,Rui Amaral Mendes,Beth M. Beadle,Siri Beier Jensen,Deborah P. Saunders +18 more
TL;DR: In this paper, the authors provide guidance regarding best practices in the prevention and management of medication-related osteonecrosis of the jaw (MRONJ) in patients with cancer.
Journal ArticleDOI
Treatment of late sequelae after radiotherapy for head and neck cancer
Primož Strojan,Katherine A. Hutcheson,Avraham Eisbruch,Jonathan J. Beitler,Johannes A. Langendijk,Anne W.M. Lee,June Corry,William M. Mendenhall,Robert Smee,Alessandra Rinaldo,Alfio Ferlito +10 more
TL;DR: The available evidence on the use of different therapeutic strategies to alleviate common late sequelae of RT in head and neck cancer patients is reviewed, with a focus on the critical assessment of the treatment options for xerostomia, dysphagia, mandibular osteoradionecrosis, trismus, and hearing loss.
References
More filters
Journal ArticleDOI
Acupuncture for pilocarpine-resistant xerostomia following radiotherapy for head and neck malignancies.
Peter A.S. Johnstone,Peter A.S. Johnstone,Y.Peter Peng,Byron C. May,Warren S Inouye,Richard C Niemtzow +5 more
TL;DR: Acupuncture reduces xerostomia in some patients who are otherwise refractory to best current management, and this report describes the use of acupuncture as palliation for such patients.
Journal ArticleDOI
A comparison of intensity-modulated radiation therapy and concomitant boost radiotherapy in the setting of concurrent chemotherapy for locally advanced oropharyngeal carcinoma.
Nancy Y. Lee,Fernando F. de Arruda,Dev R. Puri,Suzanne L. Wolden,Ashwatha Narayana,James Mechalakos,Ennapadam Venkatraman,Dennis H. Kraus,Ashok R. Shaha,Jatin P. Shah,David G. Pfister,Michael J. Zelefsky +11 more
TL;DR: In the setting of CT for locally advanced oropharyngeal carcinoma, IMRT results in lower toxicity and similar treatment outcomes when compared with CBRT, which is well-matched for all prognostic factors.
Journal ArticleDOI
Sparing of the submandibular glands by intensity modulated radiotherapy in the treatment of head and neck cancer.
Kauko Saarilahti,Mauri Kouri,Juhani Collan,Aki Kangasmäki,Timo Atula,Heikki Joensuu,Mikko Tenhunen +6 more
TL;DR: Submandibular gland sparing with IMRT is safe in selected patients treated for head and neck cancer and is effective in prevention of radiation-associated xerostomia.
Journal ArticleDOI
Oral Pilocarpine: A Review of its Pharmacological Properties and Clinical Potential in Xerostomia
Lynda R. Wiseman,Diana Faulds +1 more
TL;DR: Pilocarpine is an effective agent for the treatment of xerostomia, increasing salivary flow and reducing symptom severity to a significantly greater extent than placebo, and its efficacy relative to that of otherSalivary stimulants.
Journal ArticleDOI
Intensity modulated radiotherapy for head and neck cancer: evidence for preserved salivary gland function.
Kauko Saarilahti,Mauri Kouri,Juhani Collan,Tuomo Hämäläinen,Timo Atula,Heikki Joensuu,Mikko Tenhunen +6 more
TL;DR: The results suggest that much of the salivary gland function can be maintained with IMRT without jeopardizing the local control rate in the treatment of locally advanced oropharynx or nasopharynx carcinoma.
Related Papers (5)
A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life
Siri Beier Jensen,Anne Marie Lynge Pedersen,Arjan Vissink,Elo Andersen,C. G. Brown,Andrew Davies,J. Dutilh,Janet S. Fulton,Ljiljana Janković,Nilza Nelly Fontana Lopes,A. L. S. Mello,L. V. Muniz,C. A. Murdoch-Kinch,Raj G. Nair,Joel J. Napeñas,A. Nogueira-Rodrigues,Deborah P. Saunders,B. Stirling,I. von Bültzingslöwen,Dianna Weikel,Linda S. Elting,Frederik Spijkervet,Michael T. Brennan +22 more
Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial.
Christopher M. Nutting,Christopher M. Nutting,James P Morden,Kevin J. Harrington,Kevin J. Harrington,Teresa Guerrero Urbano,Shreerang Bhide,Catharine H. Clark,Elizabeth Miles,Aisha Miah,Kate Newbold,Mary Anne Lagmay Tanay,Fawzi Adab,Sarah Jefferies,Christopher D Scrase,Beng K. Yap,Roger A'Hern,M. Sydenham,M. Emson,Emma Hall +19 more