Journal ArticleDOI
Adult stem cell plasticity: Fact or artifact?
Reads0
Chats0
TLDR
There has been unprecedented recent interest in stem cells, mainly because of the hope they offer for cell therapy, and examples of plasticity where differentiated cells or their precursors can be reprogrammed by extracellular cues to alter their character in ways that could have important implications for cell Therapy and other forms of regenerative treatment.Abstract:
There has been unprecedented recent interest in stem cells, mainly because of the hope they offer for cell therapy. Adult stem cells are an attractive source of cells for therapy, especially in view of the recent claims that they are remarkably plastic in their developmental potential when exposed to new environments. Some of these claims have been either difficult to reproduce or shown to be misinterpretations, leaving the phenomenon of adult stem cell plasticity under a cloud. There are, however, other examples of plasticity where differentiated cells or their precursors can be reprogrammed by extracellular cues to alter their character in ways that could have important implications for cell therapy and other forms of regenerative treatment.read more
Citations
More filters
Journal ArticleDOI
Adult neurogenesis in the mammalian central nervous system
Guo Li Ming,Hongjun Song +1 more
TL;DR: Advances in the understanding of adult neurogenesis will not only shed light on the basic principles of adult plasticity, but also may lead to strategies for cell replacement therapy after injury or degenerative neurological diseases.
Journal ArticleDOI
Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche.
Charlotte A. Collins,Charlotte A. Collins,Irwin Olsen,Peter S. Zammit,Louise Heslop,Aviva Petrie,Terence A. Partridge,Jennifer E. Morgan +7 more
TL;DR: Within a normally stable tissue, the satellite cell exhibits archetypal stem cell properties and is competent to form the basal origin of adult muscle regeneration.
Journal ArticleDOI
Plasticity of Adult Stem Cells
Amy J. Wagers,Irving L. Weissman +1 more
TL;DR: Current evidence suggests that in vivo such unexpected transformations of adult somatic stem cells are exceedingly rare and in some cases can be accounted for by equally unexpected alternative explanations.
Journal ArticleDOI
Side Population Is Enriched in Tumorigenic, Stem-Like Cancer Cells, whereas ABCG2+ and ABCG2− Cancer Cells Are Similarly Tumorigenic
Lubna Patrawala,Tammy Calhoun,Robin Schneider-Broussard,Jianjun Zhou,Jianjun Zhou,Kent Claypool,Dean G. Tang +6 more
TL;DR: The results suggest that the side population is enriched with tumorigenic stem-like cancer cells,ABCG2 expression identifies mainly fast-cycling tumor progenitors, and the ABCG2- population contains primitive stem- like cancer cells.
Journal ArticleDOI
The Histone H3 Lysine-27 Demethylase Jmjd3 Links Inflammation to Inhibition of Polycomb-Mediated Gene Silencing
Francesca De Santa,Maria Grazia Totaro,Elena Prosperini,Samuele Notarbartolo,Giuseppe Testa,Gioacchino Natoli +5 more
TL;DR: The discovery of an inducible enzyme that erases a histone mark controlling differentiation and cell identity provides a link between inflammation and reprogramming of the epigenome, which could be the basis for macrophage plasticity and might explain the differentiation abnormalities in chronic inflammation.
References
More filters
Journal ArticleDOI
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
Journal ArticleDOI
Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
Journal ArticleDOI
Stem cells, cancer, and cancer stem cells
TL;DR: Stem cell biology has come of age: Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine.
Journal ArticleDOI
Establishment in culture of pluripotential cells from mouse embryos
TL;DR: The establishment in tissue culture of pluripotent cell lines which have been isolated directly from in vitro cultures of mouse blastocysts are reported, able to differentiate either in vitro or after innoculation into a mouse as a tumour in vivo.
Journal ArticleDOI
Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
Brent A. Reynolds,Samuel Weiss +1 more
TL;DR: Cells of the adult mouse striatum have the capacity to divide and differentiate into neurons and astrocytes.