Journal ArticleDOI
Alternatively activated microglia and macrophages in the central nervous system.
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TLDR
Cumulative evidence shows that microglia may undergo the alternative activation pathway, express M2-type markers and contribute to neuroprotection, and in the approaches available for its identification.About:
This article is published in Progress in Neurobiology.The article was published on 2015-06-08. It has received 521 citations till now. The article focuses on the topics: Neuroinflammation & Microglia.read more
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Macrophage plasticity, polarization, and function in health and disease.
Abbas Shapouri-Moghaddam,Saeed Mohammadian,Hossein Vazini,Mahdi Taghadosi,Seyed-Alireza Esmaeili,Fatemeh Mardani,Bita Seifi,Asadollah Mohammadi,Jalil Tavakol Afshari,Amirhossein Sahebkar +9 more
TL;DR: The protective and pathogenic role of the macrophage subsets in normal and pathological pregnancy, anti‐microbial defense, anti-tumor immunity, metabolic disease and obesity, asthma and allergy, atherosclerosis, fibrosis, wound healing, and autoimmunity are discussed.
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Microglia in Physiology and Disease
TL;DR: The diversity of microglia phenotypes and their responses in health, aging, and disease are described and treatment options that modulate microglial phenotypes are discussed.
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Blood-brain barrier dysfunction and recovery after ischemic stroke.
Xiaoyan Jiang,Xiaoyan Jiang,Anuska V. Andjelkovic,Ling Zhu,Tuo Yang,Michael V. L. Bennett,Michael V. L. Bennett,Jun Chen,Jun Chen,Richard F. Keep,Yejie Shi +10 more
TL;DR: With the development of novel research tools, future research on theBBB is likely to reveal promising potential therapeutic targets for protecting the BBB and improving patient outcome after ischemic stroke.
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Cannabinoids and the expanded endocannabinoid system in neurological disorders.
TL;DR: The biology of cannabinoids, the endocannabinoid system and the expanded endoc cannabinoidoid system are outlined and the involvement in and clinical relevance of these systems and the therapeutic potential of cannabinoids across the spectrum of neurological disease are discussed.
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Neuroinflammation and depression: A review
Romain Troubat,Pascal Barone,Samuel Leman,Thomas Desmidt,Arnaud Cressant,Boriana Atanasova,Bruno Brizard,Wissam El Hage,Alexandre Surget,Catherine Belzung,Vincent Camus +10 more
TL;DR: The intricated dynamic crosstalk between neuro inflammation and other relevant neurobiological correlates of depression add to evidence that neuroinflammation may be a key therapeutic target for future therapeutic strategies in major depressive disorder.
References
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Exploring the full spectrum of macrophage activation.
TL;DR: This Review suggests a new grouping of macrophages based on three different homeostatic activities — host defence, wound healing and immune regulation, and proposes that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation.
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The chemokine system in diverse forms of macrophage activation and polarization.
Alberto Mantovani,Alberto Mantovani,Antonio Sica,Silvano Sozzani,Silvano Sozzani,Paola Allavena,Annunciata Vecchi,Massimo Locati +7 more
TL;DR: Recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo
TL;DR: Using in vivo two-photon imaging in neocortex, it is found that microglial cells are highly active in their presumed resting state, continually surveying their microenvironment with extremely motile processes and protrusions.
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Microglia: a sensor for pathological events in the CNS
TL;DR: An understanding of intercellular signalling pathways for microglia proliferation and activation could form a rational basis for targeted intervention on glial reactions to injuries in the CNS.