Journal ArticleDOI
An electronic nose in the discrimination of patients with asthma and controls
Silvano Dragonieri,Robert Schot,Bart Mertens,Saskia le Cessie,S A Gauw,Antonio Spanevello,Onofrio Resta,Nico Willard,Teunis J. Vink,Klaus F. Rabe,Elisabeth H. Bel,Peter J. Sterk,Peter J. Sterk +12 more
Reads0
Chats0
TLDR
These findings warrant validation of electronic noses in diagnosing newly presented patients with asthma, and patients with mild and severe asthma could be less well discriminated.Abstract:
Background Exhaled breath contains thousands of volatile organic compounds (VOCs) that could serve as biomarkers of lung disease. Electronic noses can distinguish VOC mixtures by pattern recognition. Objective We hypothesized that an electronic nose can discriminate exhaled air of patients with asthma from healthy controls, and between patients with different disease severities. Methods Ten young patients with mild asthma (25.1 ± 5.9 years; FEV 1 , 99.9 ± 7.7% predicted), 10 young controls (26.8 ± 6.4 years; FEV 1 , 101.9 ± 10.3), 10 older patients with severe asthma (49.5 ± 12.0 years; FEV 1 , 62.3 ± 23.6), and 10 older controls (57.3 ± 7.1 years; FEV 1 , 108.3 ± 14.7) joined a cross-sectional study with duplicate sampling of exhaled breath with an interval of 2 to 5 minutes. Subjects inspired VOC-filtered air by tidal breathing for 5 minutes, and a single expiratory vital capacity was collected into a Tedlar bag that was sampled by electronic nose (Cyranose 320) within 10 minutes. Smellprints were analyzed by linear discriminant analysis on principal component reduction. Cross-validation values (CVVs) were calculated. Results Smellprints of patients with mild asthma were fully separated from young controls (CVV, 100%; Mahalanobis distance [M-distance], 5.32), and patients with severe asthma could be distinguished from old controls (CVV, 90%; M-distance, 2.77). Patients with mild and severe asthma could be less well discriminated (CVV, 65%; M-distance, 1.23), whereas the 2 control groups were indistinguishable (CVV, 50%; M-distance, 1.56). The duplicate samples replicated these results. Conclusion An electronic nose can discriminate exhaled breath of patients with asthma from controls but is less accurate in distinguishing asthma severities. Clinical implication These findings warrant validation of electronic noses in diagnosing newly presented patients with asthma.read more
Citations
More filters
Journal ArticleDOI
Review: A review of advanced techniques for detecting plant diseases
TL;DR: In this article, the authors present a review of the currently used technologies that can be used for developing a ground-based sensor system to assist in monitoring health and diseases in plants under field conditions.
Journal ArticleDOI
Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease
TL;DR: This approach is already suggesting entirely novel pathways to disease-eg, alternative macrophage specification, steroid refractory innate immunity, the interleukin-17-regulatory T-cell axis, epidermal growth factor receptor co-amplification, and Th2-mimicking but non-T-cell,interleukins 18 and 33 dependent processes that can offer unexpected therapeutic opportunities for specific patient endotypes.
Journal ArticleDOI
Applications and advances in electronic-nose technologies.
TL;DR: This paper is a review of the major electronic-nose technologies developed since this specialized field was born and became prominent in the mid 1980s, and a summarization of some of the more important and useful applications that have been of greatest benefit to man.
Journal ArticleDOI
An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD.
Silvano Dragonieri,Silvano Dragonieri,Jouke T. Annema,Robert Schot,Marc P. van der Schee,Marc P. van der Schee,Antonio Spanevello,Pierluigi Carratù,Onofrio Resta,Klaus F. Rabe,Peter J. Sterk,Peter J. Sterk +11 more
TL;DR: VOC-patterns of exhaled breath discriminates patients with lung cancer from COPD patients as well as healthy controls, and the electronic nose may qualify as a non-invasive diagnostic tool for lung cancer in the future.
Journal ArticleDOI
A European respiratory society technical standard : exhaled biomarkers in lung disease
Ildiko Horvath,Peter J. Barnes,Stelios Loukides,Peter J. Sterk,Marieann Högman,Anna-Carin Olin,Anton Amann,Balazs Antus,Eugenio Baraldi,Andras Bikov,Agnes W. Boots,Lieuwe D. J. Bos,Paul Brinkman,C. Bucca,Giovanna Elisiana Carpagnano,Massimo Corradi,Simona M. Cristescu,Johan C. de Jongste,Anh Tuan Dinh-Xuan,Edward Dompeling,Niki Fens,Stephen J. Fowler,Jens M. Hohlfeld,Jens M. Hohlfeld,Olaf Holz,Quirijn Jöbsis,Kim D G van de Kant,Hugo H. Knobel,Konstantinos Kostikas,Lauri Lehtimäki,Jon O. Lundberg,Paolo Montuschi,Alain Van Muylem,Giorgio Pennazza,Petra Reinhold,Fabio Luigi Massimo Ricciardolo,Philippe P.R. Rosias,Marco Santonico,Marc P. van der Schee,Frederik-Jan van Schooten,Antonio Spanevello,Thomy Tonia,Teunis J. Vink +42 more
TL;DR: Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice, and highlighting future research priorities in the field.
References
More filters
Journal ArticleDOI
Smoothing and Differentiation of Data by Simplified Least Squares Procedures.
Journal ArticleDOI
Standardisation of spirometry
Martin R. Miller,John L. Hankinson,Vito Brusasco,Felip Burgos,Richard Casaburi,Allan L. Coates,Robert O. Crapo,Paul L. Enright,C.P.M. van der Grinten,P. Gustafsson,R. Jensen,D.C. Johnson,Neil R. MacIntyre,Roy T. McKay,Daniel Navajas,O. F. Pedersen,Riccardo Pellegrino,Giovanni Viegi,J. Wanger +18 more
TL;DR: This research presents a novel and scalable approach called “Standardation of LUNG FUNCTION TESTing” that combines “situational awareness” and “machine learning” to solve the challenge of integrating nanofiltration into the energy system.
Journal ArticleDOI
Principal component analysis
TL;DR: Principal Component Analysis is a multivariate exploratory analysis method useful to separate systematic variation from noise and to define a space of reduced dimensions that preserve noise.
Journal ArticleDOI
A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
Linda B. Buck,Richard Axel +1 more
TL;DR: This work has cloned and characterized 18 different members of an extremely large multigene family that encodes seven transmembrane domain proteins whose expression is restricted to the olfactory epithelium and is likely to encode a diverse family of odorant receptors.
Journal ArticleDOI
The Mahalanobis distance
TL;DR: The Mahalanobis distance, in the original and principal component (PC) space, will be examined and interpreted in relation with the Euclidean distance (ED).