Journal ArticleDOI
Anti-cancer effects of Polyphyllin I: An update in 5 years
TLDR
This review periodically summarized the recent advances in regard to PPI's anti-tumor propensities in various cancers and the underlying mechanisms for future prospective research.About:
This article is published in Chemico-Biological Interactions.The article was published on 2020-01-25. It has received 35 citations till now.read more
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Association of the Epithelial-Mesenchymal Transition (EMT) with Cisplatin Resistance.
Milad Ashrafizadeh,Ali Zarrabi,Kiavash Hushmandi,Kiavash Hushmandi,Mahshad Kalantari,Reza Mohammadinejad,Tahereh Javaheri,Gautam Sethi +7 more
TL;DR: The various targeted signaling pathways that could be considered in future studies to pave the way for the inhibition of EMT-mediated resistance displayed by tumor cells in response to CP exposure are highlighted.
Journal ArticleDOI
Inhibitory effects of Paris saponin I, II, VI and VII on HUVEC cells through regulation of VEGFR2, PI3K/AKT/mTOR, Src/eNOS, PLCγ/ERK/MERK, and JAK2-STAT3 pathways.
TL;DR: Evaluation of the anti-angiogenic properties of the four saponins in Rhizoma Paris on vascular endothelial cells-HUVEC cells shows that, with increases in concentrations of PSI, PSII, PSVI and PSVII, the viability of HUV EC cells decreased significantly, and the mechanism was investigated to investigate the underlying mechanism.
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Injectable shear-thinning polylysine hydrogels for localized immunotherapy of gastric cancer through repolarization of tumor-associated macrophages.
TL;DR: In this paper, a shear-thinning, injectable hydrogel co-loaded with polyphyllin II (PP2) and resiquimod (R848) (PR-Gel) was developed for potentiating localized immunotherapy of gastric cancer through the repolarization of TAMs.
Journal ArticleDOI
Activation of FOXO3 pathway is involved in polyphyllin I-induced apoptosis and cell cycle arrest in human bladder cancer cells
TL;DR: Findings suggested that PPI exerted a cytotoxic effect in vitro and an antitumor activity in vivo against BCa partly by activating FOXO3 signaling pathway, and may serve as a promising chemotherapy agent for BCa treatment.
Journal ArticleDOI
Targeting the Interplay of Autophagy and ROS for Cancer Therapy: An Updated Overview on Phytochemicals
TL;DR: In this paper , the complex regulatory relationship between autophagy and ROS in cancer, with an emphasis on phytochemicals that regulate ROS and autophagia for cancer therapy is discussed.
References
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Journal ArticleDOI
Methods in Mammalian Autophagy Research
TL;DR: Methods to monitor autophagy and to modulate autophagic activity are discussed, with a primary focus on mammalian macroautophagy.
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Activation of Apoptosis Signalling Pathways by Reactive Oxygen Species
TL;DR: ROS play a central role in cell signalling as well as in regulation of the main pathways of apoptosis mediated by mitochondria, death receptors and the endoplasmic reticulum, and current understanding of the role of ROS in each of these three main pathways is focused on.
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The control of DNA repair by the cell cycle
TL;DR: How DNA repair processes, and DNA double-strand break repair in particular, are regulated during the cell cycle to optimize genomic integrity is reviewed.
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Modulating ROS to overcome multidrug resistance in cancer.
Qingbin Cui,Jing-Quan Wang,Yehuda G. Assaraf,Liang Ren,Pranav Gupta,Liuya Wei,Charles R. Ashby,Dong-Hua Yang,Zhe-Sheng Chen +8 more
TL;DR: The critical and targetable redox-regulating enzymes, including mitochondrial electron transport chain complexes, NADPH oxidases (NOXs), enzymes related to glutathione metabolism, glutamate/cystine antiporter xCT, thioredoxin reductases (TrxRs), nuclear factor erythroid 2-related factor 2 (Nrf2), and their roles in regulating cellular ROS levels, drug resistance as well as their clinical significance are discussed.