Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review.
Changmin Kim,Bonglee Kim +1 more
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TLDR
In this paper, a review of ER stress mechanisms in major cancers as well as the suppressive impact of natural products against cancers via ER stress is presented, highlighting strategies for cancer therapy by utilizing ER stress.Abstract:
Cancer is the second biggest cause of death worldwide. Despite a number of studies being conducted, the effective mechanism for treating cancer has not yet been fully understood. The tumor-microenvironment such as hypoxia, low nutrients could disturb function of endoplasmic reticulum (ER) to maintain cellular homeostasis, ultimately leading to the accumulation of unfolded proteins in ER, so-called ER stress. The ER stress has a close relation with cancer. ER stress initiates unfolded protein response (UPR) to re-establish ER homeostasis as an adaptive pathway in cancer. However, persistent ER stress triggers the apoptotic pathway. Therefore, blocking the adaptive pathway of ER stress or facilitating the apoptotic pathway could be an anti-cancer strategy. Recently, natural products and their derivatives have been reported to have anti-cancer effects via ER stress. Here, we address mechanisms of ER stress-mediated apoptosis and highlight strategies for cancer therapy by utilizing ER stress. Furthermore, we summarize anti-cancer activity of the natural products via ER stress in six major types of cancers globally (lung, breast, colorectal, gastric, prostate and liver cancer). This review deepens the understanding of ER stress mechanisms in major cancers as well as the suppressive impact of natural products against cancers via ER stress.read more
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Endoplasmic Reticulum Stress and Unfolded Protein Response in Breast Cancer: The Balance between Apoptosis and Autophagy and Its Role in Drug Resistance.
Lorenza Sisinni,Michele Pietrafesa,Silvia Lepore,Francesca Maddalena,Valentina Condelli,Franca Esposito,Matteo Landriscina +6 more
TL;DR: This review focuses on the relationship between ER stress, apoptosis, and autophagy in human breast cancer and the interplay between the activation of UPR and resistance to anticancer therapies with the aim to disclose novel therapeutic scenarios.
Journal ArticleDOI
Role of Endoplasmic Reticulum Stress in the Anticancer Activity of Natural Compounds.
Patrizia Limonta,Roberta M. Moretti,Monica Marzagalli,Fabrizio Fontana,Michela Raimondi,Marina Montagnani Marelli +5 more
TL;DR: Different plant-derived natural compounds, such as curcumin, resveratrol, green tea polyphenols, tocotrienols, and garcinia derivates, that exert their anticancer activity via ER stress modulation in different human cancers are presented.
Journal ArticleDOI
Creating and screening natural product libraries
TL;DR: The general methods used to collect organisms, extract those organisms, and create a prefractionated library are described and post-screen dereplication and compound purification and scale up procedures which can efficiently identify active compounds and produce sufficient quantities of natural products for further pre-clinical development are described.
Journal ArticleDOI
Cancer Cell Membrane-Camouflaged Nanorods with Endoplasmic Reticulum Targeting for Improved Antitumor Therapy.
Wei Zhang,Miaorong Yu,Ziyue Xi,Di Nie,Zhuo Dai,Jie Wang,Jie Wang,Kun Qian,Huixian Weng,Yong Gan,Lu Xu +10 more
TL;DR: CCM-coated nanorods (CRs) exhibited improved immune escape ability, rapid extracellular matrix penetration, and enhanced tumor accumulation, further contributing to the enhanced antitumor efficacy, suggesting the significance of shape design in improving current cell membrane-based drug delivery systems for effective subcellular targets and tumor therapy.
Journal ArticleDOI
Natural products: A lead for drug discovery and development.
TL;DR: In this article, a literature survey has been carried out to determine the utility of natural molecules and their modified analogs or derivatives as pharmacological active entities, and the importance of natural products in terms of drug discovery and development.
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